JP2013014530A - Whitening composition - Google Patents
Whitening composition Download PDFInfo
- Publication number
- JP2013014530A JP2013014530A JP2011147556A JP2011147556A JP2013014530A JP 2013014530 A JP2013014530 A JP 2013014530A JP 2011147556 A JP2011147556 A JP 2011147556A JP 2011147556 A JP2011147556 A JP 2011147556A JP 2013014530 A JP2013014530 A JP 2013014530A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- extract
- oil
- following formula
- diethyl ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 230000002087 whitening effect Effects 0.000 title claims abstract description 26
- 239000000284 extract Substances 0.000 claims abstract description 82
- -1 carbazole alkaloid compound Chemical class 0.000 claims abstract description 53
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 16
- 239000004480 active ingredient Substances 0.000 claims abstract description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 147
- 229930013930 alkaloid Natural products 0.000 claims description 41
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 150000007524 organic acids Chemical class 0.000 claims description 5
- 241000207199 Citrus Species 0.000 claims description 3
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Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Indole Compounds (AREA)
Abstract
Description
本発明は、美白用組成物に関する。
詳細には、本発明は、アルカロイドを有効成分とする美白用組成物に関する。
より詳細には、本発明は、カルバゾール型アルカロイドを有効成分とする美白用組成物に関する。
The present invention relates to a whitening composition.
Specifically, the present invention relates to a whitening composition containing an alkaloid as an active ingredient.
More specifically, the present invention relates to a whitening composition containing a carbazole type alkaloid as an active ingredient.
カラピンチャ(Murraya koenigii L.)(和名:ナンヨウサンショウ)は、インドを原産とするミカン科ゲッキツ属の多年生植物である。
カラピンチャは、カレーリーフ(curry leaf)との別名を有する程、インドから東南アジアにかけて庭などに植えられており、葉をとって各家庭で料理に使われている植物である。
Carrapincha (Murraya koenigii L.) is a perennial plant belonging to the genus Ganchiaceae, native to India.
Carapincha is a plant that is planted in gardens from India to Southeast Asia to the extent that it has an alias called curry leaf, and is used for cooking in households.
また、カラピンチャは伝承薬としても用いられてきており、葉部には強壮、解熱、健胃、鎮吐、下痢止め効果があり、全草には皮膚の発疹、咬創の治療効果があり、樹皮や根は、刺激剤として用いられる。その他、駆風薬や抗糖尿病、抗高血圧、マラリヤなどの抗周期性疾患の治療、抗カビ作用が伝承されている(非特許文献1)。 Carapincha has also been used as a traditional medicine. The leaves have tonicity, antipyretic, stomach upset, antiemetic, and anti-diarrheal effects, and the whole plant has therapeutic effects on skin rashes and bite wounds. The root is used as a stimulant. In addition, antipulmonary drugs, anti-diabetes, anti-hypertension, anti-periodic diseases such as malaria, and anti-fungal activity have been handed down (Non-patent Document 1).
また、カラピンチャの学名ムラヤ コエニギイの枝のエタノール抽出物がチロシナーゼ活性を有することが報告されている(特許文献1)が、葉部の作用および有効成分については、何ら具体的には記載されていない。 In addition, it has been reported that the ethanol extract of the branch of Karapincha's scientific name Muraya Koenigii has tyrosinase activity (Patent Document 1), but nothing specifically describes the action and active ingredients of the leaves. .
本発明は、カラピンチャの乾燥葉部およびその抽出物の新規利用方法の開発を課題とする。 This invention makes it a subject to develop the novel utilization method of the dried leaf part of a cara pincha and its extract.
本発明者は、鋭意努力研究を重ねた結果、驚くべきことに、カラピンチャの葉部の2%酢酸水溶液で抽出した抽出物を、28%アンモニア水で弱アルカリ性とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキスおよび該抽出物に含まれ、新規化合物4種を含む14種のカルバゾール型アルカロイドがメラニン生成抑制効果を有することを見出し、本発明を完成するに至った。 As a result of intensive research, the inventor has surprisingly obtained an extract obtained by extracting a 2% aqueous acetic acid solution from the leaves of carapincha with a weak alkalinity with 28% aqueous ammonia and extracting it with diethyl ether. The present inventors have found that 14 kinds of carbazole type alkaloids contained in the extracted diethyl ether extract and the extract and containing 4 kinds of novel compounds have a melanin production inhibitory effect, thereby completing the present invention.
しかるに、本発明によれば、 以下の一般式(I):
R1は、次の式:
R1、R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R4、R5、R6、R7およびR8は、互いに独立して、水素原子またはヒドロキシ基もしくはメチル基である]
で表されるカルバゾール型アルカロイド化合物が提供される。
R 2 and R 3 are taken together to form the following formula:
R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom, a hydroxy group or a methyl group]
The carbazole type alkaloid compound represented by these is provided.
また、本発明によれば、ミカン科ゲッキツ属カラピンチャ(Murraya koenigii L.)の葉部の2%酢酸水溶液抽出物を、28%アンモニア水で弱アルカリ性とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキスを有効成分とする美白用組成物が提供される。 In addition, according to the present invention, a 2% acetic acid aqueous extract of the leaf portion of the citrus family Murraya koenigii L. is made weakly alkaline with 28% aqueous ammonia and extracted with diethyl ether. A whitening composition comprising an ether extract as an active ingredient is provided.
本発明によれば、カラピンチャの葉部の2%酢酸水溶液抽出物を、28%アンモニア水で弱アルカリ性とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキス、あるいは該抽出物に含まれるカルバゾール型アルカロイドを有効成分とする美白用組成物および美白効果を有する新規カルバゾール型アルカロイドを、主に日焼け防止を目的として安全に使用できる。 According to the present invention, a 2% acetic acid aqueous solution extract of carapincha leaves made weakly alkaline with 28% aqueous ammonia and extracted with diethyl ether, or carbazole contained in the extract A whitening composition containing a type alkaloid as an active ingredient and a novel carbazole type alkaloid having a whitening effect can be safely used mainly for the purpose of preventing sunburn.
本発明による美白用組成物は、ミカン科ゲッキツ属カラピンチャ(Murraya koenigii L.)の細断した乾燥葉部の希有機酸水溶液抽出物を、弱アルカリ性(pH7.5〜9.0)とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキス、あるいは該抽出物に含まれるカルバゾール型アルカロイドを有効成分とすることを特徴とする。 A whitening composition according to the present invention is obtained by diluting a diluted organic acid aqueous solution extract of dried leaf portions of the shredded genus Murraya koenigii L. with weak alkalinity (pH 7.5-9.0), diethyl A diethyl ether extract obtained by extraction with ether or a carbazole type alkaloid contained in the extract is used as an active ingredient.
本発明によれば、カラピンチャの葉部に含まれる、以下の一般式(I):
R1は、次の式:
R1、R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R4、R5、R6、R7およびR8は、互いに独立して、水素原子またはヒドロキシ基もしくはメチル基である]
で表されるカルバゾール型アルカロイド化合物を提供できることを特徴とする。
R 2 and R 3 are taken together to form the following formula:
R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom, a hydroxy group or a methyl group]
The carbazole type alkaloid compound represented by these can be provided.
また、本発明によれば、カラピンチャの葉部に含まれる前記の一般式(I)の化合物が、以下の式:
また、本発明によれば、前記有効成分が、以下の一般式(II):
R1、R5およびR8は、互いに独立して、次の式:
R1、R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R 1 , R 2 and R 3 are taken together to form the following formula:
R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R4は、水素原子またはメチル基であり;
R6は、水素原子またはヒドロキシ基、メチル基もしくはメトキシ基であり;
R7は、水素原子またはヒドロキシもしくはメトキシ基である]
で表されるカルバゾール型アルカロイド化合物である美白用組成物が提供される。
R 4 is a hydrogen atom or a methyl group;
R 6 is a hydrogen atom or a hydroxy group, a methyl group or a methoxy group;
R 7 is a hydrogen atom or a hydroxy or methoxy group]
The whitening composition which is the carbazole type alkaloid compound represented by these is provided.
さらに、本発明によれば、前記有効成分が、以下の:
本発明において用いられるミカン科ゲッキツ属カラピンチャの葉部の産地は、特に限定されるものではない。
また、本発明において用いられるカラピンチャの葉部は、採取した新鮮な葉部および乾燥した葉部のいずれをも、そのまままたは細断して用いることができる。
また、カラピンチャの葉部の採集時期としては、特に限定されるものではない。
The locality of the leaf part of the citrus Gecki genus Carapincha used in the present invention is not particularly limited.
In addition, as the leaf portion of the carapincha used in the present invention, any of the collected fresh leaf portion and dried leaf portion can be used as it is or after being shredded.
Moreover, it is not specifically limited as a collection time of the leaf part of carapincha.
本発明によるカラピンチャの葉部の抽出に用いられる、「希有機酸」とは、酢酸2容量%を含むイオン交換水、イオン交換蒸留水およびミリポア水のいずれかの水溶液を意味する。
なお、上記の酢酸水溶液の代わりに、シュウ酸、クエン酸またはコハク酸などの有機酸水溶液を用いることもできる。また、希有機酸水溶液の弱アルカリ性化には28%アンモニア水が用いられる。
The “dilute organic acid” used for the extraction of the leaf portion of the carapincha according to the present invention means an aqueous solution of any one of ion-exchanged water, ion-exchanged distilled water and Millipore water containing 2% by volume of acetic acid.
Note that an organic acid aqueous solution such as oxalic acid, citric acid, or succinic acid can be used instead of the above-mentioned acetic acid aqueous solution. Further, 28% ammonia water is used for weak alkalinization of the dilute organic acid aqueous solution.
これらの抽出溶媒は、抽出材料に対して、1〜50倍(容量)程度、好ましくは10〜30倍(容量)程度用いられる。 These extraction solvents are used in an amount of about 1 to 50 times (volume), preferably about 10 to 30 times (volume) with respect to the extraction material.
抽出温度は、室温〜溶媒の沸点の間で任意に設定できるが、上記の抽出材料を上記の抽出溶媒に浸漬して、例えば50℃〜抽出溶媒の沸点の温度で、振盪下もしくは非振盪下または還流下に抽出するのが適当である。
抽出材料を振盪下に浸漬する場合には、30分間〜10時間程度行うのが適当であり、非振盪下に浸漬する場合には、1時間〜20日間程度行うのが適当である。
The extraction temperature can be arbitrarily set between room temperature and the boiling point of the solvent, but the above extraction material is immersed in the above extraction solvent, for example, at a temperature of 50 ° C. to the boiling point of the extraction solvent, with shaking or without shaking. Or it is suitable to extract under reflux.
When the extraction material is immersed under shaking, it is appropriate to carry out for about 30 minutes to 10 hours, and when it is immersed under non-shaking, it is appropriate to carry out for about 1 hour to 20 days.
また、抽出溶媒の還流下に抽出するときは、30分〜数時間加熱還流するのが好ましい。
なお、50℃より低い温度や室温で浸漬して抽出することも可能であるが、その場合には、上記の時間よりも長時間浸漬するのが好ましい。
Moreover, when extracting under reflux of an extraction solvent, it is preferable to heat to reflux for 30 minutes to several hours.
In addition, although it is possible to extract by immersing at a temperature lower than 50 ° C. or at room temperature, it is preferable to immerse for a longer time than the above time.
抽出操作は、同一材料について1回だけ行ってもよいが、複数回、例えば、2〜5回程度繰り返すのが、抽出効率の観点から好ましい。
本発明のおけるカラピンチャの葉部の上記位の2%酢酸水溶液抽出混合物から固形物を除去して得られる抽出液を、冷却後28%アンモニア水で弱アルカリ性とし、ジエチルエーテル抽出処理し、得られたジエチルエーテル可溶画分(抽出液)を常法により濃縮してジエチルエーテル抽出エキスが得られる。
Although extraction operation may be performed only once about the same material, it is preferable from a viewpoint of extraction efficiency to repeat several times, for example, about 2 to 5 times.
The extract obtained by removing solids from the 2% acetic acid aqueous solution extraction mixture at the above-mentioned position of the leaf portion of the carapincha in the present invention is made weakly alkaline with 28% aqueous ammonia after cooling and extracted with diethyl ether. The diethyl ether-soluble fraction (extract) is concentrated by a conventional method to obtain a diethyl ether extract.
常法により減圧濃縮して抽出エキスおよび抽出物とし、減圧濃縮の際に回収される溶媒は、再度抽出に利用できる。 A solvent is recovered by concentration under reduced pressure to obtain an extract extract and extract, and the solvent recovered at the time of concentration under reduced pressure can be used again for extraction.
分配抽出は、当該分野で通常行われる撹拌もしくは振盪分配法または液滴向流分配法などの常法に従って行うことができる。例えば、室温下、振盪下または非振盪下に、抽出エキスの水溶液に対して、酢酸エチル、n−ブタノールまたはジエチルエーテルを1/5〜5倍(容量)(1:0.2〜1:5)程度加えて行うのが適当である。 The partition extraction can be performed according to a conventional method such as a stirring or shaking distribution method or a droplet counter-current distribution method usually performed in the art. For example, ethyl acetate, n-butanol or diethyl ether is 1/5 to 5 times (volume) (1: 0.2 to 1: 5) with respect to the aqueous extract extract solution at room temperature, with shaking or without shaking. ) It is appropriate to add about.
濃縮は、減圧下に抽出エキスが乾固するまで行ってもよい。
したがって、本願発明における抽出物とは、溶媒が完全に留去された抽出エキス、抽出エキスを減圧下に乾固するまで溶媒を留去した抽出物および抽出液を凍結乾燥して得られる凍結乾燥物のいずれをも意味し、該抽出物と抽出エキスは同義である。
Concentration may be performed until the extract is dried under reduced pressure.
Accordingly, the extract in the present invention is an extract obtained by completely evaporating the solvent, an extract obtained by evaporating the solvent until the extract is dried under reduced pressure, and a freeze-dried product obtained by freeze-drying the extract. This means any product, and the extract and extract are synonymous.
抽出エキスは、そのまま本発明の組成物を調製するのに用いてもよいが、粉末状または凍結乾燥品などにより固形化して用いてもよい。これらの固形物とする方法は、当該分野で公知の方法を採用することができる。 The extract may be used as it is to prepare the composition of the present invention, but may be used after being solidified with a powder or lyophilized product. A method known in the art can be adopted as the method for forming these solids.
さらに、上記の抽出液は、濃縮する前後に精製処理に付してもよい。
精製処理は、吸着クロマトグラフ法、イオン交換クロマトグラフ法、溶媒による分配抽出などを単独または組み合わせて採用することができる。
Furthermore, the above extract may be subjected to a purification treatment before and after concentration.
As the purification treatment, an adsorption chromatography method, an ion exchange chromatography method, a partition extraction with a solvent, or the like can be employed alone or in combination.
例えば、クロマトグラフ法としては、順相もしくは逆相担体またはイオン交換樹脂を用いるカラムクロマトグラフィー、薄層クロマトグラフィー、高速液体クロマトグラフィーまたは遠心液体クロマトグラフィーなどのいずれか、またはそれらを組み合わせてアルカロイド含有画分を分取する方法が挙げられる。
この際の担体、溶出溶媒などの精製条件は、各種クロマトグラフィーに対応して適宜選択することができる。
For example, as a chromatographic method, any one of column chromatography, thin layer chromatography, high performance liquid chromatography, centrifugal liquid chromatography, etc. using a normal phase or reverse phase carrier or ion exchange resin, or a combination thereof, contains an alkaloid. The method of fractionating a fraction is mentioned.
In this case, purification conditions such as a carrier and an elution solvent can be appropriately selected according to various chromatographies.
上記のジエチルエーテル可溶画分が、カルバゾール型アルカロイド含有画分として得られる。 The above diethyl ether soluble fraction is obtained as a carbazole-type alkaloid-containing fraction.
上記のエチルエーテル可溶画分の減圧濃縮物を、前記のような精製処理、すなわち、順相クロマトグラフィー、逆相クロマトグラフィーおよび逆相高速液体クロマトグラフィーのいずれか単独で、またはこれらを組合わせて精製することもできる。
各生成段階および各画分は、ドラーゲンドルフ試薬によるアルカロイドの検出方法により、アルカロイドの存在の有無をチェックすることが好ましい。
The reduced-pressure concentrate of the ethyl ether-soluble fraction is subjected to the purification treatment as described above, that is, normal phase chromatography, reverse phase chromatography and reverse phase high performance liquid chromatography alone or in combination. And can be purified.
Each production stage and each fraction is preferably checked for the presence or absence of alkaloids by a method for detecting alkaloids using the Dragendorf reagent.
本発明者は、スリランカ産カラピンチャの乾燥葉部(500 g)を、2%酢酸水溶液(7.5 L)を用い、80 ℃で3時間抽出後、室温に冷却してろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性(pH7.5〜9.0)とした。 The inventor extracted the dried leaf part (500 g) of Sri Lankan carapincha using a 2% acetic acid aqueous solution (7.5 L) at 80 ° C. for 3 hours, cooled to room temperature, filtered, and the filtrate was 28% ammonia. It was made weakly alkaline (pH 7.5-9.0) with water (150 mL).
上記の弱アルカリ性液に同容量のジエチルエーテルを加えて抽出し、ジエチルエーテル画分と水溶液画分を得た。
上記の操作を計3回繰り返し行い、得られたジエチルエーテル抽出液を合わせ、減圧濃縮して、ジエチルエーテル抽出エキスを得た。
The weak alkaline solution was extracted by adding the same volume of diethyl ether to obtain a diethyl ether fraction and an aqueous solution fraction.
The above operation was repeated a total of 3 times, and the obtained diethyl ether extracts were combined and concentrated under reduced pressure to obtain a diethyl ether extract.
本発明者は、上記のジエチルエーテル抽出エキスがメラニン生成抑制作用を有し美白効果を有することを見出し、さらに研究を進めたところ、以下に示す4種の新規カルバゾール型アルカロイド化合物ならびに10種の既知カルバゾール型アルカロイド化合物がそれぞれ強力なメラニン生成抑制作用を有し美白効果を有することを見出し、本発明を完成するに至った。 The present inventor has found that the above diethyl ether extract has a melanin production-inhibiting action and a whitening effect, and further researches, the following four new carbazole-type alkaloid compounds and ten known ones are shown below. The inventors have found that each carbazole type alkaloid compound has a strong melanin production inhibitory action and a whitening effect, and has completed the present invention.
得られたジエチルエーテル抽出エキスを、順相シリカゲルカラムクロマトグラフィー、逆相ODSカラムクロマトグラフィーおよびODS HPLCを用いて繰り返し分離精製し、4種の新規カルバゾール型アルカロイド化合物として、カラピナミンA(karapinamine A)、カラピナミンB(karapinamine B)、カラピナミンC(karapinamine C)、カラピナミンD(karapinamine D)、および10種の既知カルバゾール型アルカロイドとしてマハニムビシン(mahanimbicine)、マハニムビン(mahanimbine)、ムヤマミン−B(murrayamine-B)、O−メチルマハニン(O-methylmahanine)、ピラヤフォリン−D(pyrayafoline-D)、エウスチフォリン−C(eustifoline-C)、エウクレスチン−B(euchrestine-B)、ギリニムビン(girinimbine)、コエニムビン(koenimbine)、ムラヤミン−E(murrayamine-E)を得た。 The obtained diethyl ether extract was repeatedly separated and purified using normal phase silica gel column chromatography, reverse phase ODS column chromatography and ODS HPLC, and as four kinds of new carbazole type alkaloid compounds, carapinamine A (karapinamine A), Carapinamine B (karapinamine B), carapinamine C (karapinamine C), carapinamine D (karapinamine D), and ten known carbazole-type alkaloids, mahanimbicine, mahanimbine, muyamamin-B (murrayamine-B), O -Methylmahanine (O-methylmahanine), pyrayaforin-D (pyrayafoline-D), eustifolin-C (eustifoline-C), euchrestine-B (euchrestine-B), girinimbine (girinimbine), coenimbine (koenimbine), murayamine-E ( murrayamine-E) was obtained.
上記で得られたカラピンチャの乾燥葉部から単離された化合物を以下に示す。
カラピンチャの乾燥葉部含有化合物
Carapincha's dry leaf-containing compound
本発明によれば、上記のカルバゾール型アルカロイドのいずれかを単独で、もしくは組み合せて、または上記のカルバゾール型アルカロイドを含有する前記のジエチルエーテルアルカロイド含有抽出エキスを、美白用組成物として用いることができる。
その場合の使用量としては、例えば化粧品に用いられる公知の他の添加剤または賦形剤を含む製品中に、例えば0.001重量%〜5重量%の割合で用いることができる。
According to the present invention, any of the above carbazole type alkaloids can be used alone or in combination, or the above diethyl ether alkaloid-containing extract containing the above carbazole type alkaloid can be used as a whitening composition. .
In this case, the amount used may be, for example, 0.001 to 5% by weight in a product containing other known additives or excipients used in cosmetics.
したがって、本発明による美白用組成物は、局所または全身用の皮膚化粧品類;頭皮・頭髪に適用する薬用および/または化粧用の製剤類;浴湯に投じて使用する浴用剤;皮膚貼付用シートおよび化粧用シートなどの適当な形態とすることができる。 Therefore, the whitening composition according to the present invention comprises a topical or systemic skin cosmetic; a medicinal and / or cosmetic preparation applied to the scalp and hair; a bathing agent used by pouring in bath water; a sheet for skin application And it can be made into suitable forms, such as a cosmetic sheet.
具体的には、化粧水、乳液、クリーム、軟膏、ジェル、ローション、オイル、パック、ミストおよび顔面用化粧シートなどの基礎化粧料;シャンプー、リンスおよびヘアートリートメントなどの頭髪化粧料;ファンデーション、頬紅などのメークアップ化粧品などが挙げられる。 Specifically, basic cosmetics such as lotion, milky lotion, cream, ointment, gel, lotion, oil, pack, mist and facial cosmetic sheet; hair cosmetics such as shampoo, rinse and hair treatment; foundation, blusher, etc. Make-up cosmetics.
尚、本発明の美白用組成物には、前記の有効成分に加え必要に応じて、本発明の効果を損なわない範囲内で以下の各種成分や添加剤を任意に選択併用し、当業者に公知の方法に従って、上記の各種化粧品を製造することができる。 In addition, the whitening composition of the present invention can be optionally combined with the following various components and additives within the range not impairing the effects of the present invention, if necessary, in addition to the above-mentioned effective ingredients. The various cosmetics described above can be produced according to known methods.
油脂類
アボガド油、アーモンド油、ウイキョウ油、エゴマ油、オリーブ油、オレンジ油、オレンジラファー油、ゴマ油、カカオ脂、カミツレ油、カロット油、キューカンバー油、牛脂脂肪酸、ククイナッツ油、サフラワー油、シア脂、液状シア脂、大豆油、ツバキ油、トウモロコシ油、ナタネ油、パーシック油、ヒマシ油、綿実油、落花生油、タートル油、ミンク油、卵黄油、パーム油、パーム核油、モクロウ、ヤシ油、牛脂、豚脂、スクワレン、スクワラン、プリスタンまたはこれら油脂類の水素添加物(硬化油など)。
Oils and fats Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao oil, chamomile oil, carrot oil, cucumber oil, beef fat fatty acid, cucumber nut oil, safflower oil, shea fat, Liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, Pork fat, squalene, squalane, pristane or hydrogenated products of these fats and oils (hardened oil, etc.).
ロウ類
ミツロウ、カルナバロウ、鯨ロウ、ラノリン、液状ラノリン、還元ラノリン、硬質ラノリン、カンデリラロウ、モンタンロウ、セラックロウ、ライスワックス。
Wax beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax.
鉱物油
流動パラフィン、ワセリン、パラフィン、オゾケライド、セレシン、マイクロクリスタンワックス。
Mineral oils Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax.
脂肪酸類
ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸、エイコサペンタエン酸、12-ヒドロキシステアリン酸、ウンデシレン酸、トール油、ラノリン脂肪酸などの天然脂肪酸、イソノナン酸、カプロン酸、2-エチルブタン酸、イソペンタン酸、2-メチルペンタン酸、2-エチルヘキサン酸、イソペンタン酸などの合成脂肪酸。
Fatty acids Natural such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Synthetic fatty acids such as fatty acids, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
アルコール類
エタノール、イソピロパノール、ラウリルアルコール、セタノール、ステアリルアルコール、オレイルアルコール、ラノリンアルコール、コレステロール、フィトステロール、フェノキシエタノールなどの天然アルコール、2-ヘキシルデカノール、イソステアリルアルコール、2-オクチルドデカノールなどの合成アルコール。
Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
多価アルコール類
酸化エチレン、エチレングリコール、ジエチレングリコール、トリエチレングリコール、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ポリエチレングリコール、酸化プロピレン、プロピレングリコール、ポリプロピレングリコール、1,3-ブチレングリコール、ペンチルグリコール、グリセリン、ペンタエリトリトール、トレイトール、アラビトール、キシリトール、リビトール、ガラクチトール、ソルビトール、マンニトール、ラクチトール、マルチトール。
Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1, 3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol.
エステル類
ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸オレイル、オレイン酸デシル、ミリスチン酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、フタル酸ジエチル、フタル酸ジブチル、酢酸ラノリン、モノステアリン酸エチレングリコール、モノステアリン酸プロピレングリコール、ジオレイン酸プロピレングリコール。
Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate , Dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate.
金属セッケン類
ステアリン酸アルミニウム、ステアリン酸マグネシウム、ステアリン酸亜鉛、ステアリン酸カルシウム、パルミチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛。
Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate.
ガム質、糖類または水溶性高分子化合物
アラビアゴム、ベンゾインゴム、ダンマルゴム、グアヤク脂、アイルランド苔、カラヤゴム、トラガントゴム、キャロブゴム、クインシード、寒天、カゼイン、乳糖、果糖、ショ糖またはそのエステル、トレハロースまたはその誘導体、デキストリン、ゼラチン、ペクチン、デンプン、カラギーナン、カルボキシメチルキチンまたはキトサン、エチレンオキサイドなどのアルキレン(C2〜C4)オキサイドが付加されたヒドロキシアルキル(C2〜C4)キチンまたはキトサン、低分子キチンまたはキトサン、キトサン塩、硫酸化キチンまたはキトサン、リン酸化キチンまたはキトサン、アルギン酸またはその塩、ヒアルロン酸またはその塩、コンドロイチン硫酸またはその塩、ヘパリン、エチルセルロース、メチルセルロース、カルボキシメチルセルロース、カルボキシエチルセルロース、カルボキシエチルセルロースナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ニトロセルロース、結晶セルロース、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、ポリビニルメタアクリレート、ポリアクリル酸塩、ポリエチレンオキサイドやポリプロピレンオキサイドなどのポリアルキレンオキサイドまたはその架橋重合物、カルボキシビニルポリマー、ポリエチレンイミン。
Gum, sugar or water-soluble polymer compound Gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or its ester, trehalose or its Derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C 2 -C 4 ) chitin or chitosan to which alkylene (C 2 -C 4 ) oxide such as ethylene oxide is added, small molecule Chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethyl cellulose , Methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, carboxyethyl cellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene Polyalkylene oxides such as oxides or cross-linked polymers thereof, carboxyvinyl polymers, polyethyleneimines.
界面活性剤
アニオン界面活性剤:アルキルカルボン酸塩、アルキルスルホン酸塩、アルキル硫酸エステル塩、アルキルリン酸エステル塩;カチオン界面活性剤:アルキルアミン塩、アルキル四級アンモニウム塩);両性界面活性剤;カルボン酸型両性界面活性剤:アミノ型、ベタイン型;硫酸エステル型両性界面活性剤;スルホン酸型両性界面活性剤;リン酸エステル型両性界面活性剤;非イオン界面活性剤:エーテル型非イオン界面活性剤、エーテルエステル型非イオン界面活性剤、エステル型非イオン界面活性剤、ブロックポリマー型非イオン界面活性剤、含窒素型非イオン界面活性剤;その他の界面活性剤:天然界面活性剤、タンパク質加水分解物の誘導体、高分子界面活性剤、チタン・ケイ素を含む界面活性剤、フッ化炭素系界面活性剤。
Surfactant Anionic surfactant: alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt; cationic surfactant: alkylamine salt, alkyl quaternary ammonium salt); amphoteric surfactant; Carboxylic acid type amphoteric surfactant: amino type, betaine type; sulfate type amphoteric surfactant; sulfonic acid type amphoteric surfactant; phosphate ester type amphoteric surfactant; nonionic surfactant: ether type nonionic interface Activators, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants; other surfactants: natural surfactants, proteins Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Sex agent.
各種ビタミン類
)ビタミンA群:レチノール、レチナール(ビタミンA1)、デヒドロレチナール(ビタミンA2)、カロチン、リコピン(プロビタミンA)、ビタミンB群:チアミン塩酸塩、チアミン硫酸塩(ビタミンB1)、リボフラビン(ビタミンB2)、ピリドキシン(ビタミンB6)、シアノコバラミン(ビタミンB12)、葉酸類、ニコチン酸類、パントテン酸類、ビオチン類、コリン、イノシトール類、ビタミンC群:ビタミンC酸またはその誘導体、ビタミンD群:エルゴカルシフェロール(ビタミンD2)、コレカルシフェロール(ビタミンD3)、ジヒドロタキステロール、ビタミンE群:ビタミンEまたはその誘導体、ユビキノン類、ビタミンK群:フィトナジオン(ビタミンK1)、メナキノン(ビタミンK2)、メナジオン(ビタミンK3)、メナジオール(ビタミンK4)、その他、必須脂肪酸(ビタミンF)、カルニチン、フェルラ酸、γ−オリザノール、オロット酸、ビタミンP類(ルチン、エリオシトリン、ヘスペリジン)、ビタミンU。
Various vitamins
) Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2) , Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vita) Min K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U.
各種アミノ酸類
バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジンなどや、それらの硫酸塩、リン酸塩、硝酸塩、クエン酸塩、或いはピロリドンカルボン酸などのアミノ酸誘導体。
Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, Amino acid derivatives such as ornithine and histidine, and sulfates, phosphates, nitrates, citrates, and pyrrolidone carboxylic acids thereof.
植物または動物系原料由来の種々の添加物
これらは、添加しようとする製品種別、形態に応じて常法的に行われる加工(例えば、粉砕、製粉、洗浄、加水分解、醗酵、精製、圧搾、抽出、分画、ろ過、乾燥、粉末化、造粒、溶解、滅菌、pH調整、脱臭、脱色などを任意に選択、組合わせた処理)を行い、各種の素材から任意に選択して供すれば良い。
Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification, pressing, Extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are arbitrarily selected and combined), and selected from various materials. It ’s fine.
尚、抽出に用いる溶媒については、供する製品の使用目的、種類、或いは後に行う加工処理などを考慮した上で選択すれば良いが、通常では、水、メタノール、エタノール、プロピルアルコール、イソプロピルアルコール、ブタノール、イソブタノールなどの低級アルコール或いは含水低級アルコール、プロピレングリコール、1,3-ブチレングリコール、グリセリンなどの多価アルコール或いは含水多価アルコール、アセトン、酢酸エチルなどの各種有機溶媒の中から選ばれる1種若しくは2種以上の混液を用いるのが望ましい。但し、用途により有機溶媒の含有が好ましくない場合においては、水のみを使用したり、あるいは抽出後に除去しやすいエタノールを採用し、単独または水との任意の混液で用いたりすれば良く、また、搾取抽出したものでも良い。 The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol , One kind selected from various alcohols such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.
尚、植物または動物系原料由来の添加物を、全身用または局所用の外用剤、化粧料類に供する場合、皮膚や頭髪の保護をはじめ、保湿、感触・風合いの改善、柔軟性の付与、刺激の緩和、芳香によるストレスの緩和、細胞賦活(細胞老化防止)、炎症の抑制、肌質・髪質の改善、肌荒れ防止およびその改善、発毛、育毛、脱毛防止、光沢の付与、清浄効果、疲労の緩和、血流促進、温浴効果などの美容的効果のほか、香付け、消臭、増粘、防腐、緩衝などの効果も期待できる。
原料とする植物(生薬)としては、当業者に公知の生薬または動物由来の材料が用いられる。
In addition, when using additives derived from plant or animal raw materials for systemic or topical external preparations, cosmetics, including skin and hair protection, moisturizing, improving touch and texture, imparting flexibility, Stimulation relief, stress reduction by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin quality and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, prevention of hair loss, imparting luster, cleansing effect In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorizing, thickening, preserving, and buffering can also be expected.
As the plant (herbal medicine) used as a raw material, herbal medicine or animal-derived material known to those skilled in the art is used.
海藻類
海藻類としては、緑藻類、褐藻類、紅藻類、藍藻類、車軸藻類、黄色藻類などが挙げられる。
Seaweed Seaweed includes green algae, brown algae, red algae, cyanobacteria, axle algae, yellow algae and the like.
動物系原料由来の素材
また、動物系原料由来の素材としては、牛、豚、鶏または魚類のコラーゲン加水(酸、アルカリ、酵素など)分解物や水溶性コラーゲンまたはアシル化コラーゲンなどのコラーゲン誘導体、牛または豚のエラスチンまたはエラスチン加水分解物(酸、アルカリ、酵素など)または水溶性エラスチン誘導体、ケラチンおよびその分解物またはそれらの誘導体、シルク蛋白およびその分解物またはそれらの誘導体、牛乳、カゼインおよびその分解物またはそれらの誘導体、脱脂粉乳およびその分解物またはそれらの誘導体、ラクトフェリンまたはその分解物、鶏卵成分、魚肉分解物、核酸関連物質(リボ核酸、デオキシリボ核酸)が挙げられる。
Ingredients derived from animal-based materials In addition, materials derived from animal-based materials include collagen hydrolysates of cattle, pigs, chickens or fish (acids, alkalis, enzymes, etc.), collagen derivatives such as water-soluble collagen or acylated collagen, Bovine or porcine elastin or elastin hydrolyzate (acid, alkali, enzyme, etc.) or water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk protein and its degradation products or their derivatives, milk, casein and its Examples include degradation products or derivatives thereof, skim milk powder and degradation products or derivatives thereof, lactoferrin or degradation products thereof, egg components, fish degradation products, and nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid).
海洋成分
深層水などの海水類、例えば、海水塩、海水乾燥物、死海または大西洋または太平洋の海より得た無機塩(塩化ナトリウム、塩化マグネシウム、塩化カリウムなど)、海泥または泥(ファンゴ)類、例えば、イタリアファンゴ、ドイツファンゴ、アイフェルファンゴ、フライブルグファンゴなどの各地の海泥または泥(含有成分:二酸化珪素、二酸化チタン、酸化アルミニウム、酸化鉄、酸化マンガン、酸化ナトリウム、酸化カリウム、酸化マグネシウム、酸化カルシウム、酸化ストロンチウム、ナトリウム、カリウム、マグネシウム、カルシウム、クロム、鉄、銅、ニッケル、亜鉛、鉛、マンガン、ヒ素、水)、聖徳石、黒耀石が挙げられる。
Marine components Seawater such as deep sea water, eg sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) For example, sea mud or mud from various locations such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, Calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, and black meteorite.
微生物培養代謝物
酵母代謝物、酵母菌抽出エキス、細菌代謝物、細菌抽出エキス、カビまたは放線菌代謝物、カビまたは放線菌抽出エキス、納豆菌代謝物、納豆抽出エキス、米発酵エキス、米糠(赤糠、白糠)発酵エキス、ユーグレナ抽出物またはその分解物またはそれら水溶性誘導体、トレハロースまたはその誘導体、生乳または脱脂粉乳の乳酸発酵物、マメ科植物の乳酸菌発酵物、ココヤシ属植物の乳酸菌発酵物が挙げられる。
Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomyces extract, natto metabolite, natto extract, rice fermentation extract, rice bran ( (Red cocoon, white birch) fermented extract, Euglena extract or degradation product thereof or water-soluble derivatives thereof, trehalose or derivatives thereof, lactic acid fermentation product of raw milk or skim milk, lactic acid bacteria fermentation product of legumes, lactic acid bacteria fermentation product of coconut genus plant Is mentioned.
無機顔料
無水ケイ酸、ケイ酸マグネシウム、タルク、カオリン、ベントナイト、マイカ、雲母チタン、オキシ塩化ビスマス、酸化ジルコニウム、酸化マグネシウム、酸化亜鉛、酸化チタン、炭酸カルシウム、炭酸マグネシウム、黄酸化鉄、ベンガラ、黒酸化鉄、グンジョウ、酸化クロム、水酸化クロム、カーボンブラック、カラミンが挙げられる。
Inorganic pigments Silicic acid anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black Examples thereof include iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, and calamine.
紫外線吸収/遮断剤
ベンゾフェノン誘導体(2-ヒドロキシ-4-メトキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸ナトリウム、ジヒドロキシジメトキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン−スルホン酸ナトリウム、2,4-ジヒドロキシベンゾフェノン、テトラヒドロキシベンゾフェノンなど)、パラアミノ安息香酸誘導体(パラアミノ安息香酸、パラアミノ安息香酸エチル、パラアミノ安息香酸グリセリル、パラジメチルアミノ安息香酸アミル、パラジメチルアミノ安息香酸オクチルなど)、メトキシ桂皮酸誘導体(パラメトキシ桂皮酸エチル、パラメトキシ桂皮酸イソプロピル、パラメトキシ桂皮酸オクチル、パラメトキシ桂皮酸2-エトキシエチル、パラメトキシ桂皮酸ナトリウム、パラメトキシ桂皮酸カリウム、ジパラメトキシ桂皮酸モノ-2-エチルヘキサン酸グリセリルなど)、サリチル酸誘導体(サリチル酸オクチル、サリチル酸フェニル、サリチル酸ホモメンチル、サリチル酸ジプロピレングリコール、
UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, Dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, paradimethylamino Octyl benzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyparamethoxycinnamate) Ethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, di-2-methoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
サリチル酸エチレングリコール、サリチル酸ミリスチル、サリチル酸メチルなど)、アントラニル酸誘導体(アントラニル酸メチルなど)、ウロカニン酸誘導体(ウロカニン酸、ウロカニン酸エチルなど)、クマリン誘導体、アミノ酸系化合物、ベンゾトリアゾール誘導体、テトラゾール誘導体、イミダゾリン誘導体、ピリミジン誘導体、ジオキサン誘導体、カンファー誘導体、フラン誘導体、ピロン誘導体、核酸誘導体、アラントイン誘導体、ニコチン酸誘導体、ビタミンB6誘導体、ウンベリフェロン、エスクリン、桂皮酸ベンジル、シノキサート、オキシベンゾン、ジオキシベンゾン、オクタベンゾン、スリソベンゾン、ベンゾレソルシノール、アルブチン、グアイアズレン、シコニン、バイカリン、バイカレイン、ベルベリン、ネオヘリオパン、エスカロール、酸化亜鉛、タルク、カオリンが挙げられる。 Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, Surisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neo Riopan, ESKA rolls, zinc oxide, talc, kaolin.
美白剤
パラアミノ安息香酸誘導体、サルチル酸誘導体、アントラニル酸誘導体、クマリン誘導体、アミノ酸系化合物、ベンゾトリアゾール誘導体、テトラゾール誘導体、イミダゾリン誘導体、ピリミジン誘導体、ジオキサン誘導体、カンファー誘導体、フラン誘導体、ピロン誘導体、核酸誘導体、アラントイン誘導体、ニコチン酸誘導体、ビタミンCまたはその誘導体(ビタミンCリン酸エステルマグネシウム塩、ビタミンCグルコシドなど)、ビタミンEまたはその誘導体、コウジ酸またはその誘導体、オキシベンゾン、ベンゾフェノン、アルブチン、グアイアズレン、シコニン、バイカリン、バイカレイン、ベルベリン、胎盤エキス、エラグ酸、ルシノールが挙げられる。
Whitening agent Paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, Allantoin derivatives, nicotinic acid derivatives, vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin , Baicalein, berberine, placenta extract, ellagic acid, lucinol.
チロシナーゼ活性阻害剤
ビタミンCまたはその誘導体(ビタミンCリン酸エステルマグネシウム塩、ビタミンCグルコシドなど)、ハイドロキノンまたはその誘導体(ハイドロキノンベンジルエーテルなど)、コウジ酸またはその誘導体、ビタミンEまたはその誘導体、N−アセチルチロシンまたはその誘導体、グルタチオン、過酸化水素、過酸化亜鉛、胎盤エキス、エラグ酸、アルブチン、ルシノール、シルク抽出物、植物エキス(カミツレ、クワ、クチナシ、トウキ、ワレモコウ、クララ、ヨモギ、スイカズラ、キハダ、ドクダミ、マツホド、ハトムギ、オドリコソウ、ホップ、サンザシ、ユーカリ、セイヨウノコギリソウ、アルテア、ケイヒ、マンケイシ、ハマメリス、カラグワまたはヤマグワ、延命草、桔梗、トシシ、続随子、射干、麻黄、センキュウ、ドッカツ、サイコ、ボウフウ、ハマボウフウ、オウゴン、牡丹皮、シャクヤク、ゲンノショウコ、葛根、甘草、五倍子、アロエ、ショウマ、紅花、緑茶、紅茶、阿仙薬)が挙げられる。
Tyrosinase activity inhibitor Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or derivatives thereof (hydroquinone benzyl ether, etc.), kojic acid or derivatives thereof, vitamin E or derivatives thereof, N-acetyl Tyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camomile, mulberry, gardenia, touki, firewood, clara, mugwort, honeysuckle, yellowfin, Dokudami, Matsuhodo, pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, monkey, hamamelis, carraguwa or yamagua, life-prolonging grass, bellflower, toshishi, successor , Mao, Senkyu, Dokatsu, Psycho, Bowfu, Hamaboufu, Ogon, Peony skin, Peonies, Gennoshouko, Kakkon, Licorice, Pyrup, Aloe, Shouma, Safflower, Green tea, Black tea, Asen).
メラニン色素還元/分解物質
フェニル水銀ヘキサクロロフェン、酸化第二水銀、塩化第一水銀、過酸化水素水、過酸化亜鉛、ハイドロキノンまたはその誘導体(ハイドロキノンベンジルエーテル)が挙げられる。
Melanin Pigment Reduction / Decomposition Substances Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or derivatives thereof (hydroquinone benzyl ether).
細胞賦活物質
ターンオーバーの促進作用/細胞賦活物質ハイドロキノン、乳酸菌エキス、胎盤エキス、霊芝エキス、ビタミンA、ビタミンE、アラントイン、脾臓エキス、胸腺エキス、酵母エキス、発酵乳エキス、植物エキス(アロエ、オウゴン、スギナ、ゲンチアナ、ゴボウ、シコン、ニンジン、ハマメリス、ホップ、ヨクイニン、オドリコソウ、センブリ、トウキ、トウキンセンカ、アマチャ、オトギリソウ、キュウリ、タチジャコウソウ、マンネンロウ、パセリ)が挙げられる。
Cell activating substance Turnover promoting action / cell activating substance hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, Hamamelis, Hop, Yokuinin, Odrichosium, Assembly, Toki, Tokisenka, Achacha, Hypericum, Cucumber, Tachiko, Mannenrou, Parsley).
収斂剤
コハク酸、アラントイン、塩化亜鉛、硫酸亜鉛、酸化亜鉛、カラミン、パラフェノールスルホン酸亜鉛、硫酸アルミニウムカリウム、レゾルシン、塩化第二鉄、タンニン酸(カテキン化合物を含む)が挙げられる。
Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds).
活性酸素消去剤
SOD、カタラーゼ、グルタチオンパーオキシダーゼが挙げられる。
Active oxygen scavengers include SOD, catalase, and glutathione peroxidase.
抗酸化剤
ビタミンCまたはその塩、ステアリン酸エステル、ビタミンEまたはその誘導体、ノルジヒドログアセレテン酸、ブチルヒドロキシトルエン(BHT)、ブチルヒドロキシアニソール(BHA)、ヒドロキシチロソール、パラヒドロキシアニソール、没食子酸プロピル、セサモール、セサモリン、ゴシポール、プロポリスが挙げられる。
Antioxidants Vitamin C or salts thereof, stearic acid ester, vitamin E or derivatives thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, gallic acid Examples include propyl, sesamol, sesamorin, gossypol, and propolis.
過酸化脂質生成抑制剤
β-カロチン、植物エキス(ゴマ培養細胞、アマチャ、オトギリソウ、ハマメリス、チョウジ、メリッサ、エンメイソウ、シラカバ、サルビア、マンネンロウ、南天実、エイジツ、イチョウ、緑茶)が挙げられる。
Lipid peroxide production inhibitor β-carotene, plant extracts (sesame cultured cells, hamcha, hypericum, hamamelis, clove, melissa, enmiso, birch, salvia, mannenrou, nanjimi, agetsu, ginkgo, green tea).
抗炎症剤
イクタモール、インドメタシン、カオリン、サリチル酸、サリチル酸ナトリウム、サリチル酸メチル、アセチルサリチル酸、塩酸ジフェンヒドラミン、d-カンフル、dl-カンフル、ヒドロコルチゾン、グアイアズレン、カマズレン、マレイン酸クロルフェニラミン、グリチルリチン酸またはその塩、グリチルレチン酸またはその塩、甘草エキス、シコンエキス、エイジツエキス、プロポリスが挙げられる。
Anti-inflammatory agents Iktamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salts, glycyrrhetin Examples thereof include acids or salts thereof, licorice extract, sicon extract, age extract, and propolis.
抗菌・殺菌・消毒薬
アクリノール、イオウ、グルコン酸カルシウム、グルコン酸クロルヘキシジン、スルファミン、マーキュロクロム、ラクトフェリンまたはその加水分解物、塩化アルキルジアミノエチルグリシン液、トリクロサン、次亜塩素酸ナトリウム、クロラミンT、サラシ粉、ヨウ素化合物、ヨードホルム、ソルビン酸またはその塩、プロピオン酸またはその塩、サルチル酸、デヒドロ酢酸、パラヒドロキシ安息香酸エステル類、ウンデシレン酸、チアミンラウリル硫酸塩、チアミンラウリル硝酸塩、フェノール、クレゾール、p-クロロフェノール、p-クロロ-m-キシレノール、p-クロロ-m-クレゾール、チモール、フェネチルアルコール、O-フェニルフェノール、イルガサンCH3565、ハロカルバン、ヘキサクロロフェン、クロロヘキシジン、エタノール、メタノール、イソプロピルアルコール、ベンジルアルコール、エチレングリコール、プロピレングリコール、2-フェノキシエタノール、1,2-ペンタンジオール、
Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride, triclosan, sodium hypochlorite, chloramine T, salashi powder, Iodine compounds, iodoform, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoates, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol , P-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol,
ジンクピリジオン、クロロブタノール、イソプロピルメチルフェノール、非イオン界面活性剤(ポリオキシエチレンラウリルエーテル、ポリオキシエチレンノニルフェニルエーテル、ポリオキシエチレンオクチルフェニルエーテルなど)、両性界面活性剤、アニオン界面活性剤(ラウリル硫酸ナトリウム、ラウロイルサルコシンカリウムなど)、カチオン界面活性剤(臭化セチルトリメチルアンモニウム、塩化ベンザルコニウム、塩化ベンゼトニウム、塩化メチルロザニリン)、ホルムアルデヒド、ヘキサミン、ブリリアントグリーン、マラカイトグリーン、クリスタルバイオレット、ジャーマル、感光素101号、感光素201号、感光素401号、N-長鎖アシル塩基性アミノ酸誘導体およびその酸附加塩、酸化亜鉛、ヒノキチオール、クジン、プロポリスが挙げられる。 Zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (lauryl) Sodium sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101 No., photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, zinc oxide, hinokitiol, Emissions, include the propolis.
保湿剤
グリセリン、プロピレングリコール、1,3-ブチレングリコール、ポリエチレングリコール、トリカプリルカプリン酸グリセリン、グリコール酸(αーヒドロキシ酸)、ヒアルロン酸またはその塩、コンドロイチン硫酸またはその塩、水溶性キチンまたはその誘導体或いはキトサン誘導体、ピロリドンカルボン酸またはその塩、乳酸ナトリウム、尿素、ソルビトール、アミノ酸またはその誘導体(バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジンや、
Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or Chitosan derivative, pyrrolidone carboxylic acid or salt thereof, sodium lactate, urea, sorbitol, amino acid or derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, Cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine,
それらの硫酸塩、リン酸塩、硝酸塩、クエン酸塩、或いはピロリドンカルボン酸)、油脂類「アボガド油、アーモンド油、ウイキョウ油、エゴマ油、オリーブ油、オレンジ油、オレンジラファー油、ゴマ油、カカオ脂、カミツレ油、カロット油、キューカンバー油、牛脂脂肪酸、クインスシード油、ククイナッツ油、サフラワー油、シア脂、液状シア脂、大豆油、ツバキ油、トウモロコシ油、ナタネ油、ホホバ油、パーシック油、ヒマシ油、ヒマワリ油、綿実油、落花生油、タートル油、ティートリー油、ミンク油、卵黄油、パーム油、パーム核油、モクロウ、ヤシ油、ユーカリ油、牛脂、豚脂、スクワレン、スクワラン、プリスタンまたはこれら油脂類の水素添加物(硬化油)」、ロウ類(ミツロウ、カルナバロウ、鯨ロウ、 (Sulphates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids), fats and oils “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, Chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, quince seed oil, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil , Sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or these oils and fats Hydrogenated product (hardened oil) ", waxes (beeswax, carnauba wax, whale wax,
ラノリン、液状ラノリン、還元ラノリン、硬質ラノリン、カンデリラロウ、モンタンロウ、セラックロウ、ライスワックス)、鉱物油(流動パラフィン、ワセリン、パラフィン、オゾケライド、セレシン、マイクロクリスタンワックス)、納豆菌代謝物、納豆抽出エキス、絹繊維抽出物、植物エキス(赤松樹液、アロエ、葛根、カミツレ、甘草、キュウリ、甘草、米または米糠、紫根、白樺または白樺樹液、センブリ、桑白皮、琵琶葉、ヘチマ、牡丹皮、蓬)が挙げられる。 Lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto metabolite, natto extract, silk Fiber extract, plant extract (red pine sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assembly, mulberry white bark, birch leaf, loofah, peony bark, persimmon) Can be mentioned.
香料
ジャコウ、シベット、カストリウム、アンバーグリスなどの天然動物性香料、アニス精油、アンゲリカ精油、イランイラン精油、イリス精油、ウイキョウ精油、オレンジ精油、カナンガ精油、カラウェー精油、カルダモン精油、グアヤクウッド精油、クミン精油、黒文字精油、ケイ皮精油、シンナモン精油、ゲラニウム精油、コパイババルサム精油、コリアンデル精油、シソ精油、シダーウッド精油、シトロネラ精油、ジャスミン精油、ジンジャーグラス精油、杉精油、スペアミント精油、西洋ハッカ精油、大茴香精油、チュベローズ精油、丁字精油、橙花精油、冬緑精油、トルーバルサム精油、バチュリー精油、バラ精油、パルマローザ精油、桧精油、ヒバ精油、白檀精油、プチグレン精油、ベイ精油、ベチバ精油、ベルガモット精油、ペルーバルサム精油、ボアドローズ精油、芳樟精油、マンダリン精油、ユーカリ精油、ライム精油、ラベンダー精油、リナロエ精油、レモングラス精油、レモン精油、ローズマリー(マンネンロウ)精油、和種ハッカ精油などの植物性香料、その他合成香料が挙げられる。
Fragrance Natural animal fragrances such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, Black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil , Tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil , Peruvian balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil And other synthetic fragrances.
色素
着色剤赤キャベツ色素、赤米色素、アカネ色素、アナトー色素、イカスミ色素、ウコン色素、エンジュ色素、オキアミ色素、柿色素、カラメル、金、銀、クチナシ色素、コーン色素、タマネギ色素、タマリンド色素、スピルリナ色素、ソバ全草色素、チェリー色素、海苔色素、ハイビスカス色素、ブドウ果汁色素、マリーゴールド色素、紫イモ色素、紫ヤマイモ色素、ラック色素、ルチンが挙げられる。
Dye Colorant Red cabbage dye, red rice dye, red pepper dye, anato dye, squid ink dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, Spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin.
その他の添加剤
その他ホルモン類、金属イオン封鎖剤、pH調整剤、キレート剤、防腐・防バイ剤、清涼剤、安定化剤、乳化剤、動・植物性蛋白質およびその分解物、動・植物性多糖類およびその分解物、動・植物性糖蛋白質およびその分解物、血流促進剤、抗炎症剤・消炎剤・抗アレルギー剤、創傷治療剤、増泡剤、増粘剤、酵素、精製水(電子水、小クラスター化などを含む)、消臭・脱臭剤などが挙げられる。
Other additives Other hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animals and plants Saccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam enhancers, thickeners, enzymes, purified water ( Electronic water, small clustering, etc.), deodorant / deodorant and the like.
メラニン生成抑制作用
メラニンを生成するメラノサイトは表皮の基底層全体にわたって認められ、皮膚が日射を受けると、メラノサイトはより多くの色素を作り出し、皮膚は黄褐色または暗褐色になる。メラニンはメラノサイトやメラノーマなどといった特殊な細胞内で合成される色素性のポリマーであり、UVからの保護や色素、毒性のある化合物の吸収などに重要な役割を果たしている。
一方で最近、美白効果を目的にメラニン生成抑制物質の探索が広く行われている。
Melanin inhibitory action Melanocytes that produce melanin are found throughout the basal layer of the epidermis, and when the skin is exposed to sunlight, the melanocytes produce more pigment and the skin becomes tan or dark brown. Melanin is a pigmented polymer synthesized in special cells such as melanocytes and melanomas, and plays an important role in UV protection, pigments, and absorption of toxic compounds.
On the other hand, recently, a search for a melanin production inhibitor has been widely conducted for the purpose of whitening effect.
これら成分や添加剤と併用することによって、本発明効果または他の美容的効果の相加的または相乗的向上が期待できる。以下に、製造例、評価試験、処方例などの実施例を示し、さらに詳しく説明するが、本発明はこれらに制約されるものではない。 By using in combination with these components and additives, an additive or synergistic improvement of the effects of the present invention or other cosmetic effects can be expected. Examples of production examples, evaluation tests, formulation examples and the like are shown below and described in more detail, but the present invention is not limited thereto.
前記の美白作用を有する前記ジエチルエーテル抽出エキスに含有されるカルバゾール型アルカロイドの植物原材料としては、本発明のカラピンチャに限定されず、いずれも本願発明の原材料として使用できるものである。 The plant raw material of the carbazole-type alkaloid contained in the diethyl ether extract having the whitening effect is not limited to the carapincha of the present invention, and any of them can be used as the raw material of the present invention.
旋光度は、Horiba high sensitive SEPA-300 digital polarimeter(l = 0.5)(株式会社堀場製作所製)を用いて測定した。
高分解能質量分析(High resolution FAB-MSおよびEI-MS)ならびに質量分析(FAB-MSおよびEI-MS)は、JEOL JMS-SX 102およびJMS-GCMATE型質量分析装置(日本電子株式会社製)を用いて測定した。
The optical rotation was measured using a Horiba high sensitive SEPA-300 digital polarimeter (l = 0.5) (manufactured by Horiba, Ltd.).
For high resolution mass spectrometry (High resolution FAB-MS and EI-MS) and mass spectrometry (FAB-MS and EI-MS), the JEOL JMS-SX 102 and JMS-GCMATE mass spectrometers (manufactured by JEOL Ltd.) And measured.
水素核磁気共鳴スペクトル(1H-NMR)および炭素13核磁気共鳴スペクトル(13C-NMR)は、JEOL JNM-EX 270(270 MHz)、JNM-LA 500(500 MHz)およびJNM-ECA 600(600 MHz)(日本電子株式会社製)を用いて測定し、テトラメチルシラン(TMS)を内部標準として用いた。 Hydrogen nuclear magnetic resonance spectrum ( 1 H-NMR) and carbon 13 nuclear magnetic resonance spectrum ( 13 C-NMR) were measured using JEOL JNM-EX 270 (270 MHz), JNM-LA 500 (500 MHz) and JNM-ECA 600 ( 600 MHz) (manufactured by JEOL Ltd.) and tetramethylsilane (TMS) was used as an internal standard.
高速液体クロマトグラフィー(HPLC)は、ポンプおよび示差屈折計検出器はShimadzu LC-6ADおよびShimadzu RID-10A(株式会社島津製作所製)またはHITACHI L-2130およびHITACHI L-2490(株式会社日立製作所製)を用いた。 For high-performance liquid chromatography (HPLC), the pump and differential refractometer detector are Shimadzu LC-6AD and Shimadzu RID-10A (manufactured by Shimadzu Corporation) or HITACHI L-2130 and HITACHI L-2490 (manufactured by Hitachi, Ltd.) Was used.
カラムクロマトグラフィーの吸着剤は、順相系担持体はシリカゲルBW-200(富士シリシア化学株式会社製、150〜350メッシュ)、逆相系担持体はクロマトレックスODS DM1020T(富士シリシア化学株式会社製、100〜200メッシュ)を用いた。 For column chromatography, the normal phase support is silica gel BW-200 (manufactured by Fuji Silysia Chemical Co., Ltd., 150-350 mesh), and the reverse phase support is Chromatrex ODS DM1020T (manufactured by Fuji Silysia Chemical Co., Ltd., 100-200 mesh) was used.
薄層クロマトグラフィー(TLC)には、シリカゲル60F254(Merck社製、順相)、RP-18 60F254(Merck社製、逆相)、シリカゲル60F254 HPTLC(Merck社製、順相)、RP-18 WF254 HPTLC(Merck社製、逆相)を使用し、TLC上のスポットの検出は、UV(254 nm)および1%Ce(SO4)2 / 10%H2SO4水溶液を噴霧し、加熱時の呈色により行った。 For thin layer chromatography (TLC), silica gel 60F254 (Merck, normal phase), RP-18 60F254 (Merck, reverse phase), silica gel 60F254 HPTLC (Merck, normal phase), RP-18 WF254 Using HPTLC (Merck, reverse phase), spot detection on TLC was sprayed with UV (254 nm) and 1% Ce (SO 4 ) 2 /10% H 2 SO 4 aqueous solution and heated Performed by coloration.
試薬は、特に明記しないものは和光純薬工業株式会社製試薬(特級)を用いた。
実験で得られた数値は、平均値±標準誤差で表記し、対照群との平均値の有意差の検定にはDunnettの方法を使用し、p値が0.05以下のものを有意とみなした。
A reagent (special grade) manufactured by Wako Pure Chemical Industries, Ltd. was used unless otherwise specified.
Numerical values obtained in the experiment were expressed as mean ± standard error, Dunnett's method was used to test the significance of the mean value with the control group, and p values of 0.05 or less were considered significant.
細胞の培養は、MCO-18AIC(三洋電機株式会社製)CO2インキュベータを使用し、37℃、5%CO2存在下、飽湿状態で行った。 The cells were cultured using a MCO-18AIC (manufactured by Sanyo Electric Co.) CO 2 incubator in a saturated state in the presence of 37 ° C. and 5% CO 2 .
マウスメラノーマ細胞におけるメラニン生成抑制の判定
理研細胞バンクより分譲されたマウスメラノーマB16-メラノーマ-4A5細胞(RCB0557)を10%ウシ胎児血清(FCS)、100 ユニット/mLペニシリンおよび100 μg/mLストレプトマイシン含有DMEM(4500 mg/L グルコース)培地(Sigma-Aldrich社)で培養(5%CO2、37oC)した。
Judgment of inhibition of melanogenesis in mouse melanoma cells Mouse melanoma B16-melanoma-4A5 cells (RCB0557) distributed by RIKEN Cell Bank are DMEM containing 10% fetal calf serum (FCS), 100 units / mL penicillin and 100 μg / mL streptomycin The cells were cultured (5% CO 2 , 37 ° C) in (4500 mg / L glucose) medium (Sigma-Aldrich).
次に、24-ウェル マルチプレート(住友ベークライト社製)に2.0×104 細胞/400 μL/ウェルを播種し、24時間前培養した後、被験物質およびテオフィリン(theophylline)(終濃度1 μM)を添加した。72時間培養後、トリプシン処理により細胞を剥離、回収後、PBS洗浄し、NaOH水にて溶解(120 μL/ウェル、80oC、30 分)し、96-ウェル マイクロプレート(住友ベークライト社製)に細胞溶解液を分取(100 μL/ウェル)し、生成したメラニンの吸光度をマイクロプレートリーダー(model 550、BIO-RAD社)にて測定した(測定波長:405 nm、参照波長:655 nm)。なお、被験物質はDMSOに溶解し、培地添加した(DMSO終濃度 0.1%)。 Next, inoculate 2.0 × 10 4 cells / 400 μL / well on a 24-well multiplate (Sumitomo Bakelite Co., Ltd.), pre-culture for 24 hours, and then add the test substance and theophylline (final concentration 1 μM). Added. After culturing for 72 hours, the cells were detached and collected by trypsin treatment, washed with PBS, dissolved in NaOH water (120 μL / well, 80oC, 30 minutes), and the cells were placed in a 96-well microplate (Sumitomo Bakelite) The lysate was collected (100 μL / well), and the absorbance of the produced melanin was measured with a microplate reader (model 550, BIO-RAD) (measurement wavelength: 405 nm, reference wavelength: 655 nm). The test substance was dissolved in DMSO and added to the medium (DMSO final concentration 0.1%).
なお、阻害率は、以下の式により算出した。
阻害率(%)= [(A−B)/ A] / (C / 100) × 100
[式中、Aは被験試料未添加(コントロール)の吸光度、Bは被験試料添加の吸光度、Cは細胞生存率を意味する]
The inhibition rate was calculated by the following formula.
Inhibition rate (%) = [(A−B) / A] / (C / 100) × 100
[In the formula, A means the absorbance of the test sample not added (control), B means the absorbance of the test sample added, and C means the cell viability]
マウスメラノーマ細胞におけるWST-8 アッセイ法による細胞増殖阻害・細胞毒性の判定
B16-メラノーマ-4A5細胞を、10%ウシ胎児血清(FCS)、100ユニット/mLペニシリンおよび100 μg/mLストレプトマイシン含有DMEM(4500 mg/L glucose)培地(Sigma-Aldrich社)で培養(5%CO2、37oC)した。
Determination of cell growth inhibition and cytotoxicity in mouse melanoma cells by WST-8 assay
B16-melanoma-4A5 cells were cultured in DMEM (4500 mg / L glucose) medium (Sigma-Aldrich) containing 10% fetal calf serum (FCS), 100 units / mL penicillin and 100 μg / mL streptomycin (5% CO 2 , 37oC).
次に、96ウェル マイクロプレート(住友ベークライト社)に5.0×103 細胞/100 μL/ウェルを播種し、24時間前培養した後、被験物質およびテオフィリン(終濃度1 mM)を添加した。70時間培養後、WST-8[2-(2-メトキシ-4-ニトロフェニル)-3-(4-ニトロフェニル)-5-(2,4-ジスルホフェニル)-2H-テトラゾリウム モノナトリウム塩](同仁化学研究所製)を10 μg/mLずつ添加した。2時間培養後、生成したWST-8ホルマザンの吸光度をマイクロプレートリーダー(model 550、BIO-RAD社製)にて測定した(測定波長:450 nm、参照波長:655 nm)。なお、被験物質はDMSOに溶解し、培地添加した(DMSO終濃度 0.1%)。 Next, a 96-well microplate (Sumitomo Bakelite) was seeded with 5.0 × 10 3 cells / 100 μL / well, pre-cultured for 24 hours, and then a test substance and theophylline (final concentration 1 mM) were added. After incubation for 70 hours, WST-8 [2- (2-methoxy-4-nitrophenyl) -3- (4-nitrophenyl) -5- (2,4-disulfophenyl) -2H-tetrazolium monosodium salt] (Dojindo Laboratories) was added at 10 μg / mL. After culturing for 2 hours, the absorbance of the produced WST-8 formazan was measured with a microplate reader (model 550, manufactured by BIO-RAD) (measurement wavelength: 450 nm, reference wavelength: 655 nm). The test substance was dissolved in DMSO and added to the medium (DMSO final concentration 0.1%).
阻害率(%)=[(A−B)/ A]× 100
[式中、Aは被験試料未添加(コントロール)の吸光度を意味し、Bは被験試料添加の吸光度を意味する]
Inhibition rate (%) = [(A−B) / A] × 100
[In the formula, A means the absorbance of the test sample not added (control), and B means the absorbance of the test sample added]
チロシナーゼ阻害活性試験
96ウェル マイクロプレート(住友ベークライト社製)に2.5mM L-DOPAリン酸緩衝溶液70 μL/ウェルを分注し、調整した試料溶液(DMSO溶液)20 μLを添加した。次に、終濃度46ユニット/mLチロシナーゼリン酸緩衝溶液120 μLを添加し、酵素反応(室温、5分)を開始した。また、ブランクにはリン酸緩衝溶液を用いた。生成されたメラニンの吸光度をマイクロプレートリーダー(model 550、BIO-RAD社製)にて測定した(測定波長:450 nm、参照波長:655 nm)。
Tyrosinase inhibitory activity test
To a 96-well microplate (Sumitomo Bakelite), 70 μL / well of 2.5 mM L-DOPA phosphate buffer solution was added, and 20 μL of the prepared sample solution (DMSO solution) was added. Next, 120 μL of a final concentration of 46 units / mL tyrosinase phosphate buffer solution was added to start the enzyme reaction (room temperature, 5 minutes). Moreover, the phosphate buffer solution was used for the blank. The absorbance of the produced melanin was measured with a microplate reader (model 550, manufactured by BIO-RAD) (measurement wavelength: 450 nm, reference wavelength: 655 nm).
阻害率(%)=[(A−B)/ A] × 100
[式中、Aは被験試料未添加(コントロール)の吸光度を意味し、Bは被験試料添加の吸光度を意味する]
Inhibition rate (%) = [(A−B) / A] × 100
[In the formula, A means the absorbance of the test sample not added (control), and B means the absorbance of the test sample added]
実施例1
カラピンチャの乾燥葉部のジエチルエーテル抽出エキスおよび水溶性画分の調整
スリランカ産カラピンチャの乾燥葉部(500 g)を、2容量%酢酸水溶液(7.5 L)を用いて、80℃で3時間加熱抽出した。抽出混合物を室温に冷却後、ろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性とし、同容量のジエチルエーテル(7.5 L)で抽出した。
上記の操作を計3回繰り返し、得られたジエチルエーテル抽出液を合わせ、減圧濃縮してジエチルエーテル抽出エキス2.25 g(収率4.25%)を得た。
また、ジエチルエーテルで分配処理した水溶液を減圧濃縮して水溶性画分として478.75 gを得た。
Example 1
Diethyl ether extract and dried water-soluble fraction of dried caracapincha leaves Extracted dried leaves (500 g) of Sri Lankan carapicha using 2 vol% acetic acid aqueous solution (7.5 L) at 80 ° C for 3 hours. did. The extraction mixture was cooled to room temperature and filtered, and the filtrate was made weakly alkaline with 28% aqueous ammonia (150 mL) and extracted with the same volume of diethyl ether (7.5 L).
The above operation was repeated 3 times in total, and the obtained diethyl ether extracts were combined and concentrated under reduced pressure to obtain 2.25 g (yield 4.25%) of diethyl ether extract.
The aqueous solution partitioned with diethyl ether was concentrated under reduced pressure to obtain 478.75 g as a water-soluble fraction.
実施例2
ジエチルエーテル抽出エキスのメラニン生成抑制試験
今回、カラピンチャの乾燥葉部の前記ジエチルエーテル抽出エキスおよび前記水溶性画分について、マウスメラノーマ由来B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討したので、その結果を以下の表1に示す。
Example 2
Diethyl ether extract extract melanin production inhibition test This time, we examined the melanin production inhibitory effect in mouse melanoma-derived B16-melanoma-4A5 cells for the diethyl ether extract extract and the water-soluble fraction of dry leaves of carapincha. The results are shown in Table 1 below.
その結果、ジエチルエーテル抽出エキスには、対照および水溶性画分と比較して顕著なメラニン生成阻害活性が認められた。なお、メラニンの生成抑制率については細胞生存率を考慮した値から算出している。 As a result, the diethyl ether extract showed significant melanin production inhibitory activity as compared with the control and water-soluble fractions. In addition, about the production | generation suppression rate of melanin, it computed from the value which considered the cell survival rate.
実施例3
ジエチルエーテル抽出エキスの細胞毒性試験
次に、カラピンチャの乾燥葉部の前記ジエチルエーテル抽出エキスおよび前記水溶性画分について、マウスメラノーマ由来B16-メラノーマ-4A5細胞における細胞増殖に対する阻害効果(生存率)を検討したので、その結果を以下の表2に示す。
Example 3
Cytotoxicity test of diethyl ether extract Next, the inhibitory effect (survival rate) on cell proliferation in mouse melanoma-derived B16-melanoma-4A5 cells with respect to the diethyl ether extract and the water-soluble fraction of dried leaves of carapincha The results are shown in Table 2 below.
その結果、ジエチルエーテル抽出エキスには、対照および水溶性画分と比較して10μg/mLの濃度までは、顕著な細胞増殖抑制効果は認められなかった。 As a result, the diethyl ether extract did not show a significant cell growth inhibitory effect up to a concentration of 10 μg / mL compared to the control and water-soluble fractions.
実施例4
スリランカ産カラピンチャの乾燥葉部からの含有成分の抽出および単離
スリランカ産カラピンチャの乾燥葉部(500 g)を、2容量%酢酸水溶液(7.5 L)を用いて、80℃で3時間加熱抽出した。抽出混合物を室温に冷却後、ろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性とし、た。ろ別した植物材料については、上記と全く同じ操作をさらに2回繰り返し、中和した溶液を合わせた。
Example 4
Extraction and isolation of components from dried leaves of Sri Lankan carapincha Dry leaves (500 g) of Sri Lankan carapincha were heated and extracted at 80 ° C for 3 hours with 2% acetic acid aqueous solution (7.5 L). . The extraction mixture was cooled to room temperature and then filtered, and the filtrate was made weakly alkaline with 28% aqueous ammonia (150 mL). For the filtered plant material, the same operation as described above was further repeated twice, and the neutralized solutions were combined.
スリランカ産カラピンチャの乾燥葉部(500 g)を、2容量%酢酸水溶液(7.5 L)を用いて、80℃で3時間加熱抽出した。抽出混合物を室温に冷却後、ろ過し、濾液を28%アンモニア水(150 mL)で弱アルカリ性とし、同容量のジエチルエーテル(7.5 L)で抽出した。
上記の操作を計3回繰り返し、得られたジエチルエーテル抽出液を合わせ、減圧濃縮してジエチルエーテル抽出エキス21.25 g(収率4.25%)を得た。
また、ジエチルエーテルで分配処理した水溶液を減圧濃縮して水溶性画分として478.75 gを得た(以下のチャート1参照)。
The dried leaf part (500 g) of Sri Lankan carapincha was extracted by heating at 80 ° C. for 3 hours using a 2% by volume acetic acid aqueous solution (7.5 L). The extraction mixture was cooled to room temperature and filtered, and the filtrate was made weakly alkaline with 28% aqueous ammonia (150 mL) and extracted with the same volume of diethyl ether (7.5 L).
The above operation was repeated three times in total, and the obtained diethyl ether extracts were combined and concentrated under reduced pressure to obtain 21.25 g (yield 4.25%) of diethyl ether extract.
The aqueous solution partitioned with diethyl ether was concentrated under reduced pressure to obtain 478.75 g as a water-soluble fraction (see Chart 1 below).
上記で得られたジエチルエーテル抽出エキス(21 g)を、順相シリカゲルカラムクロマトグラフィー、逆相ODSカラムクロマトグラフィーおよびODS HPLCを用いて繰り返し分離精製し、4種の新規カルバゾール型アルカロイド化合物として、カラピナミンA(karapinamine A) (1、0.00063%)、カラピナミンB(karapinamine B) (2、0.00200%)、カラピナミンC(karapinamine C) (3、0.00029%)、カラピナミンD(karapinamine D) (4、0.00063%)を得(チャート2参照)、および10種の既知カルバゾール型アルカロイドとしてマハニムビシン(mahanimbicine) (5、211.3 mg、0.02625%)、マハニムビン(mahanimbine) (6、468.1 mg、0.08118%)、ムヤマミン−B(murrayamine-B) (7、39.5 mg、0.00322%)、O−メチルマハニン(O-methylmahanine) (8、20.3 mg、0.00211%)、ピラヤフォリン−D(pyrayafoline-D) (9、13 mg、0.00118%)、エウスチフォリン−C(eustifoline-C) (10、11.8 mg、0.00159%)、エウクレスチン−B(euchrestine-B) (11、177.1 mg、0.02385%)、ギリニムビン(girinimbine) (12、2.0 mg、0.00008%)、コエニムビン(koenimbine) (13、6.3 mg、0.00126%)、ムラヤミン−E(murrayamine-E) (14、11.6 mg、0.00156%)を得た(チャート3および4参照)。 The diethyl ether extract (21 g) obtained above was repeatedly separated and purified using normal phase silica gel column chromatography, reverse phase ODS column chromatography and ODS HPLC, and carapinamine as four kinds of new carbazole type alkaloid compounds. A (karapinamine A) (1, 0.00063%), Carapinamine B (2, 0.00200%), Carapinamine C (3, 0.00029%), Carapinamine D (4, 0.00063%) (See Chart 2), and ten known carbazole-type alkaloids, mahanimbicine (5, 211.3 mg, 0.02625%), mahanimbine (6, 468.1 mg, 0.08118%), muyamamin-B (murrayamine) -B) (7, 39.5 mg, 0.00322%), O-methylmahanine (8, 20.3 mg, 0.00211%), pyrayaphorin-D (pyrayafoline-D) (9, 13 mg, 0.00118%), eastifolin C (eustifoline-C) (10, 11.8 mg, 0.00159%), Eucrestine-B (11, 177.1 mg, 0.02385%), girinimbine (12, 2.0 mg, 0.00008%), coenimbin (koenimbine) (13, 6.3 mg, 0.00126%) and murrayamine-E (14, 11.6 mg, 0.00156%) were obtained (see charts 3 and 4).
新規カルバゾール型アルカロイドの化学構造
カラピナミンA (1) は、正の旋光度 ([α]D 24 +12.4°、MeOH) を示す黄色粉末として得られ、そのEI-MS において分子イオンピークがm/z 333 (M+) に観測され、1は高分解能 EI-MS により分子式 C23H27NO を有する化合物であることが明らかになった。
また、IRスペクトルにおいて水酸基 (3400 cm-1)、芳香環 (1509 cm-1) の存在を示唆する吸収が認められた。
Chemical structure of a novel carbazole-type alkaloid Carapinamine A (1) was obtained as a yellow powder with positive optical rotation ([α] D 24 + 12.4 °, MeOH), and its molecular ion peak was m / Observed at z 333 (M + ), 1 was found to be a compound having the molecular formula C 23 H 27 NO by high-resolution EI-MS.
In the IR spectrum, absorption suggesting the presence of a hydroxyl group (3400 cm -1 ) and an aromatic ring (1509 cm -1 ) was observed.
1の 1H-NMRスペクトルおよび13C-NMRスペクトル値(表3)から、1個のメチル基[ 2.51 (3H、s、6-CH3)]の存在が示唆された。次に、DQF-COSY、HMQC、HMBCスペクトルにおいて、フィギュア 1に太線で示すプロトン−プロトン間にDQF-COSYスペクトルの相関が、また矢印で示すプロトン−カーボン間にHMBCスペクトルの 1H-13C ロングレンジ相関が見られた。以上のことから1はゲラニル基を持つカルバゾール型アルカロイドであることが明らかにとなり、その構造をフィギュア 1に示すように決定した。 1 1 H-NMR spectrum and 13 C-NMR spectrum value (Table 3) suggested the presence of one methyl group [2.51 (3H, s, 6-CH 3 )]. Next, in the DQF-COSY, HMQC, and HMBC spectra, the correlation between the DQF-COSY spectra between protons and protons indicated by bold lines in Figure 1 and the 1 H- 13 C long of the HMBC spectra between protons and carbon indicated by arrows Range correlation was seen. From the above, it became clear that 1 was a carbazole-type alkaloid with a geranyl group, and its structure was determined as shown in Figure 1.
カラピナミンB (2) は正の旋光度 ([α]D 24 +5.64°、MeOH) を示す黄色粉末として得られ、そのEI-MS において分子イオンピークがm/z 347 (M+) に観測され、2は高分解能 EI-MS により分子式 C23H25NO2 を有する化合物であることが明らかになった。
また IR スペクトルにおいて水酸基 (3400 cm-1)、芳香環 (1601、1507 cm-1) の存在を示唆する吸収が認められた。
Carapinamine B (2) was obtained as a yellow powder with positive optical rotation ([α] D 24 + 5.64 °, MeOH), and its molecular ion peak was observed at m / z 347 (M + ) in its EI-MS 2 was revealed by high resolution EI-MS to be a compound having the molecular formula C 23 H 25 NO 2 .
In the IR spectrum, absorption suggesting the presence of hydroxyl groups (3400 cm -1 ) and aromatic rings (1601, 1507 cm -1 ) was observed.
2の1H-NMRスペクトルおよび13C-NMRスペクトル値(表3)から、4個のメチル基[ 1.26、1.43、1.85、2.37 (3H、s、H-8'、3'、9'、6)]の存在が示唆された。また2の 1H-NMR および13C-NMR のケミカルシフトは3位および6位付近を除いて既知アルカロイドムラヤミン-E (14) と類似していた。次に、DQF-COSY、HMQC、HMBC スペクトルにおいて、フィギュア 2に太線で示すプロトン−プロトン間にDQF-COSYスペクトルの相関が、また矢印で示すプロトン−カーボン間にHMBCスペクトルの 1H-13Cロングレンジ相関が見られた。このことから2カルバゾール型アルカロイドであり、その平面構造を以下のように決定した。 2 1 H-NMR spectrum and 13 C-NMR spectrum value (Table 3), 4 methyl groups [1.26, 1.43, 1.85, 2.37 (3H, s, H-8 ′, 3 ′, 9 ′, 6 )] Was suggested. The 1 H-NMR and 13 C-NMR chemical shifts of 2 were similar to those of the known alkaloid murajamin-E (14) except for the 3rd and 6th positions. Next, in the DQF-COSY, HMQC, and HMBC spectra, the correlation between the DQF-COSY spectrum between the protons and protons shown by the bold line in Figure 2 and the 1 H- 13 C long of the HMBC spectrum between the protons and carbon shown by the arrows are shown. Range correlation was seen. From this, it was a 2-carbazole type alkaloid, and its planar structure was determined as follows.
次に、NOE により3位プロトン[ 6.61]から4位プロトン[ 7.48]間、5位プロトン[ 7.62]から6-CH3位プロトン[ 2.37]間、3位プロトン[ 6.95]から8'、9'位プロトン[ 1.85、1.26]間、1'位プロトン[ 3.26]から8'位プロトン[ 1.85]間、6'位プロトン[ 1.94]から8'位プロトンおよび9'位プロトン[ 1.85、1.26]間、2'位プロトン[ 1.90]から3'-CH3位プロトン[ 1.43]間に、フィギュア 2に点線矢印で示す相関が観測されたことから23の相対配置が明らかとなった。以上の結果、2の化学構造が決定した。 Next, NOE causes protons between the 3-position proton [6.61] to the 4-position proton [7.48], the 5-position proton [7.62] to the 6-CH 3- position proton [2.37], the 3-position proton [6.95] to 8 ', 9'. Between position protons [1.85, 1.26], between position 1 'proton [3.26] to position 8' proton [1.85], position 6 'to position proton 8 [9] and proton 9' position [1.85, 1.26], The correlation indicated by the dotted arrow in Figure 2 was observed between the 2 'proton [1.90] and the 3'-CH 3 proton [1.43], revealing the relative arrangement of 23. As a result, two chemical structures were determined.
カラピナミン C (3) およびカラピナミン D (4) は負の旋光度 (3:[α]D 25 −22.6°;4:[α]D 24−15.6°、CHCl3) を示す淡黄色粉末として得られ、その EI-MS においてそれぞれ分子イオンピークがm/z 331 (M+) に観測された。3および4は高分解能 EI-MS により共通した分子式 C23H25NO を有する化合物であることが明らかになった。
また IRスペクトルにおいて水酸基(3:3450;4:3450)、芳香環(3:1618、1509;4:1615、1509)の存在を示唆する吸収が認められた。
Carapinamine C (3) and carapinamine D (4) were obtained as light yellow powders with negative optical rotation (3: [α] D 25 –22.6 °; 4: [α] D 24 – 15.6 °, CHCl 3 ). In the EI-MS, a molecular ion peak was observed at m / z 331 (M + ). 3 and 4 were clarified by high resolution EI-MS to be compounds with the common molecular formula C 23 H 25 NO.
In the IR spectrum, absorption suggesting the presence of hydroxyl groups (3: 3450; 4: 3450) and aromatic rings (3: 1618, 1509; 4: 1615, 1509) was observed.
また、既知アルカロイドビシクロマハニムビシンおよびビシクロマハニムビンの 1H-NMR および13C-NMR のケミカルシフトと一致した。次に、DQF-COSY、HMQC、HMBCスペクトルにおいて、フィギュア3に太線で示すプロトン−プロトン間にDQF-COSYスペクトルの相関が、また矢印で示すプロトン−カーボン間にHMBCスペクトルの 1H-13Cロングレンジ相関がそれぞれ見られた。このことから3、4の平面構造を決定した。 It was also consistent with the chemical shifts of 1 H-NMR and 13 C-NMR of the known alkaloids bicyclomahanimbicin and bicyclomahanimbin. Next, in the DQF-COSY, HMQC, and HMBC spectra, the correlation between the DQF-COSY spectra between protons and protons indicated by bold lines in Figure 3 and the 1 H- 13 C long of the HMBC spectra between protons and carbon indicated by arrows. Each range correlation was seen. From this, three or four planar structures were determined.
これらの平面構造はそれぞれ、ビシクロマハニムビシンおよびビシクロマハニムビンと一致していることが明らかになった。次に、NOEにより1'位プロトン[3: 3.42;4: 3.42]から2'位プロトン[3: 2.70;4: 2.66]間、2'位プロトン[3: 2.70;4: 2.66]から3'-CH3位プロトン[3: 1.36;4: 1.35]および6'位プロトン[3: 2.52;4: 2.50]間、6'位プロトン[3: 2.52;4: 2.50]から9'位プロトン[3: 1.58;4: 1.53]間、5'位プロトン[3: 1.76;4: 1.78]から8'位プロトン[3:0.67;4: 0.63]間、8'位プロトン[3: 0.67;4: 0.63]から4'位プロトン[3: 1.63;4: 1.63]間、1'位プロトン[3: 3.42;4: 3.42]から9'位プロトン[3: 1.58;4: 1.53]間に、フィギュア3に点線矢印で示す相関がそれぞれ観測されたことから3および4の相対配置が明らかとなった。以上の結果、3および4の化学構造が明らかとなった。 These planar structures were found to be consistent with bicyclomahanimbicin and bicyclomahanimbin, respectively. Next, by NOE, the 1 'position proton [3: 3.42; 4: 3.42] to the 2' position proton [3: 2.70; 4: 2.66], the 2 'position proton [3: 2.70; 4: 2.66] to 3' -CH 3 position proton [3: 1.36; 4: 1.35] and 6 'position proton [3: 2.52; 4: 2.50], 6' position proton [3: 2.52; 4: 2.50] to 9 'position proton [3 : 1.58; 4: 1.53], 5 'proton [3: 1.76; 4: 1.78] to 8' proton [3: 0.67; 4: 0.63], 8 'proton [3: 0.67; 4: 0.63 To 4 'position proton [3: 1.63; 4: 1.63], 1' position proton [3: 3.42; 4: 3.42] to 9 'position proton [3: 1.58; 4: 1.53] The relative arrangement of 3 and 4 became clear from the correlations indicated by the dotted arrows. As a result, the chemical structures of 3 and 4 were clarified.
実施例5
カラピンチャ葉部含有成分のメラニン生成抑制効果
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14) について、B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討した(表4)。
Example 5
Inhibitory Effect of Carapincha Leaves Containing Melanin Production Four novel carbazole-type lukaloids and nine known carbazole-type alkaloids (1-11, 13 and 14) isolated from the diethyl ether extract were used in B16-melanoma-4A5 cells The inhibitory action on melanin production was examined (Table 4).
その結果、カラピナミン A (1)、カラピナミン B (2)、カラピナミン C (3)、カラピナミン D (4)、マハニムビシン(5)、マハニムビン(6)、ムラヤミン-B (7)、エウスチフォリン-C (10)、エウクレスチン-B (11)、コエニムビン(13)およびムラヤミン-E (14) に活性が認められた。 As a result, carapinamine A (1), carapinamine B (2), carapinamine C (3), carapinamine D (4), mahanimbicin (5), mahanimbin (6), murajamin-B (7), eastifolin-C (10) , Eucrestin-B (11), Coenimbin (13) and Murayamin-E (14) were found active.
また、メラニン合成に関わるチロシナーゼに直接作用し、メラニンの合成を阻害するため、美白効果があるとして化粧品に広く使用されているアルブチン(arbutin) を、既存の美白効果を有する比較物質として用いた(表5)。 In addition, arbutin, which is widely used in cosmetics as a whitening effect because it directly acts on tyrosinase involved in melanin synthesis and inhibits melanin synthesis, was used as a comparative substance having an existing whitening effect ( Table 5).
上記の表1、4および5の結果から、カラピンチャのジエチルエーテル抽出エキスは、現在化粧品の美白成分として広く使用されているアルブチンよりも強力なメラニン生成抑制効果を有することが判明した。
また、上記のジエチルエーテル抽出エキスに含まれるカルバゾール型アルカロイド化合物の殆どは、上記アルブミンよりも強力なメラニン生成効果を有することが判明した。
From the results of Tables 1, 4 and 5 above, it was found that the extract of carapincha diethyl ether has a stronger melanin production inhibitory effect than arbutin, which is currently widely used as a whitening component of cosmetics.
It was also found that most of the carbazole type alkaloid compounds contained in the above extract of diethyl ether have a stronger melanin producing effect than the above albumin.
実施例6
マウスメラノーマ細胞における細胞増殖阻害効果
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14) について、B16-メラノーマ-4A5細胞におけるメラニン生成抑制作用を検討した(表6)。
Example 6
Cell growth inhibitory effect in mouse melanoma cells Four new carbazole-type lukaloids isolated from the above extract of diethyl ether and nine known carbazole-type alkaloids (1-11, 13 and 14) produced melanin in B16-melanoma-4A5 cells The inhibitory action was examined (Table 6).
また、メラニン合成に関わるチロシナーゼに直接作用し、メラニンの合成を阻害するため、美白効果があるとして化粧品に広く使用されているアルブチン(arbutin) を、既存の美白効果を有する比較物質として用い上記の作用について測定した。 In addition, arbutin, which is widely used in cosmetics as a whitening effect, acts directly on tyrosinase involved in melanin synthesis and inhibits melanin synthesis. The effect was measured.
実施例7
チロシナーゼ阻害活性試験
前記ジエチルエーテル抽出エキスから単離した新規カルバゾール型ルカロイド4種および公知カルバゾール型アルカロイド9種(1〜11、13および14)について、マッシュルーム由来のチロシナーゼに対する阻害活性について検討した(表8)。
Example 7
Tyrosinase inhibitory activity test Four novel carbazole-type lukaloids isolated from the diethyl ether extract and nine known carbazole-type alkaloids (1-11, 13 and 14) were examined for inhibitory activity against mushroom-derived tyrosinase (Table 8). ).
その結果、ピラヤフォリン-D (9)、エウスチフォリン-C (10)、ムラヤミン-E (14) に若干の活性が認められた。しかしながら、作用濃度域を考えると、表8のこれらのカルバゾール型アルカロイドの強いメラニン生成抑制作用に、チロシナーゼ阻害作用の寄与は低いことが明らかになった。 As a result, some activities were observed in pyrayaforin-D (9), eastifolin-C (10), and murajamin-E (14). However, considering the action concentration range, it has been clarified that the contribution of the tyrosinase inhibitory action to the strong melanin production inhibitory action of these carbazole type alkaloids in Table 8 is low.
以下の実施例おいて、前記の実施例3および4で得られた各アルカロイドを1種以上を組み合せて化粧品の製剤化に用いることができるが、例として前記の実施例4で得られたアルカロイド含有画分を用いて各種化粧品を作成した。 In the following examples, one or more of the alkaloids obtained in Examples 3 and 4 can be combined and used for the formulation of cosmetics. As an example, the alkaloids obtained in Example 4 are used. Various cosmetics were prepared using the contained fraction.
実施例8
化粧水の調製
以下の処方:
Preparation of lotion The following formula:
実施例9〜12
上記の実施例8においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例8と全く同様にして化粧水1kgをそれぞれ調製した。
実施例13
乳液の調製
以下の処方:
1 kg of lotion was prepared in exactly the same manner as in Example 8, except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 8 above.
Example 13
Preparation of emulsion The following formula:
実施例14〜17
上記の実施例13においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例13と全く同様にして乳液1kgをそれぞれ製造した。
Examples 14-17
1 kg of emulsion was prepared in exactly the same manner as in Example 13, except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 13 above.
実施例18
クリームの調製
以下の処方:
Cream preparation The following formula:
実施例19〜22
上記の実施例18においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例18と全く同様にしてクリーム1kgをそれぞれ製造した。
Examples 19-22
1 kg of cream was produced in the same manner as in Example 18 except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 18 above.
実施例23
日焼け止めクリームの調製
以下の処方:
Sunscreen preparation The following formula:
実施例24〜27
上記の実施例23においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例23と全く同様にして日焼け止めクリーム1kgをそれぞれ製造した。
Examples 24-27
1 kg of sunscreen was prepared in exactly the same manner as in Example 23, except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 23 above.
実施例28
ファンデーションの調製
以下の処方:
Preparation of foundation The following formulation:
実施例29〜32
上記の実施例28においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例28と全く同様にしてファンデーション1kgをそれぞれ製造した。
Examples 29-32
1 kg of foundation was produced in the same manner as in Example 28 except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 28 above.
実施例33
全身用日焼け止め乳液
以下の処方:
Whole body sunscreen latex The following prescription:
実施例34〜37
上記の実施例33においてジエチルエーテル抽出エキス0.01、0.1、1および5重量%をそれぞれ用いたこと以外は、実施例33と全く同様にして全身用日焼け止めクリーム1kgをそれぞれ製造した。
Examples 34-37
1 kg of sunscreen cream for whole body was produced in the same manner as in Example 33 except that 0.01, 0.1, 1 and 5% by weight of diethyl ether extract were used in Example 33 above.
本発明による美白用組成物は、カラピンチャの乾燥葉部の2%酢酸水溶液抽出物を、28%アンモニア水で弱アルカリ性とし、ジエチルエーテルで抽出して得られたジエチルエーテル抽出エキスならびに該抽出エキスが含有する4種の新規カルバゾール型アルカロイドおよび9種の公知のカルバゾール型アルカロイドを有効成分とし、主に日焼け防止を目的として安全に使用できる。 The whitening composition according to the present invention comprises a diethyl ether extract obtained by extracting a 2% acetic acid aqueous solution extract of dried caracacha leaves with 28% ammonia water and extracting with diethyl ether and the extract. Four kinds of new carbazole type alkaloids and nine kinds of known carbazole type alkaloids are contained as active ingredients and can be safely used mainly for the purpose of preventing sunburn.
Claims (5)
R1は、次の式:
R1、R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R4、R5、R6、R7およびR8は、互いに独立して、水素原子またはヒドロキシ基もしくはメチル基である]
で表されるカルバゾール型アルカロイド化合物。 The following general formula (I):
R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom, a hydroxy group or a methyl group]
The carbazole type alkaloid compound represented by these.
R1、R5およびR8は、互いに独立して、次の式:
R1、R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R2およびR3は、互いに一緒になって、次の式:
R4は、水素原子またはメチル基であり;
R6は、水素原子またはヒドロキシ基、メチル基もしくはメトキシ基であり;
R7は、水素原子またはヒドロキシもしくはメトキシ基である]
で表されるカルバゾール型アルカロイド化合物である美白用組成物。 The active ingredient is represented by the following general formula (II):
R 4 is a hydrogen atom or a methyl group;
R 6 is a hydrogen atom or a hydroxy group, a methyl group or a methoxy group;
R 7 is a hydrogen atom or a hydroxy or methoxy group]
The composition for whitening which is a carbazole type alkaloid compound represented by these.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170076091A (en) * | 2015-12-24 | 2017-07-04 | (주)아모레퍼시픽 | Salicylic acid derivative compounds, preparation method thereof, and whitening cosmetic composition comprising the same |
CN118126050A (en) * | 2024-05-06 | 2024-06-04 | 云南省肿瘤医院(昆明医科大学第三附属医院) | 6-Methoxy carbazole alkaloid compound and preparation method and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR754224A (en) * | 1933-11-02 | |||
JPS53116370A (en) * | 1977-03-18 | 1978-10-11 | Bayer Ag | Proess for preparing 22hydroxycarbazole |
JPH06503095A (en) * | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | Tricyclic polyhydroxy tyrosine kinase inhibitor |
JPH0782133A (en) * | 1993-09-14 | 1995-03-28 | Tsuneo Nanba | Cosmetic |
CN1309964A (en) * | 2001-02-09 | 2001-08-29 | 崔承彬 | Carbazole-alkoloid cell cycle inhibitor, cell death inducer and their preparation |
WO2005007151A1 (en) * | 2003-07-16 | 2005-01-27 | Institute Of Medicinal Molecular Design. Inc. | Chromatosis remedies |
JP2011068632A (en) * | 2009-08-28 | 2011-04-07 | National Institute Of Advanced Industrial Science & Technology | Tyrosinase inhibitor |
-
2011
- 2011-07-01 JP JP2011147556A patent/JP5844561B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR754224A (en) * | 1933-11-02 | |||
JPS53116370A (en) * | 1977-03-18 | 1978-10-11 | Bayer Ag | Proess for preparing 22hydroxycarbazole |
JPH06503095A (en) * | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | Tricyclic polyhydroxy tyrosine kinase inhibitor |
JPH0782133A (en) * | 1993-09-14 | 1995-03-28 | Tsuneo Nanba | Cosmetic |
CN1309964A (en) * | 2001-02-09 | 2001-08-29 | 崔承彬 | Carbazole-alkoloid cell cycle inhibitor, cell death inducer and their preparation |
WO2005007151A1 (en) * | 2003-07-16 | 2005-01-27 | Institute Of Medicinal Molecular Design. Inc. | Chromatosis remedies |
JP2011068632A (en) * | 2009-08-28 | 2011-04-07 | National Institute Of Advanced Industrial Science & Technology | Tyrosinase inhibitor |
Non-Patent Citations (8)
Title |
---|
JPN6015019349; Wu, Tian-Shung; Chan, Yu-Yi; Liou, Meei-Jen; Lin, Ful-Wen; Shi, Li-Shian; Chen, Kuo-Tung: 'Platelet aggregation inhibitor from Murraya euchrestifolia' Phytotherapy Research , 1998, S80-S82 * |
JPN6015019350; Joshi, Balwant S.; Kamat, Venkatesh N.; Gawad, D. H.: 'Structures of girinimbine, mahanimbine, isomahanimbine, koenimbidine, and murrayacine' Tetrahedron 26(6), 1970, 1475-82 * |
JPN6015019351; Lobastova, Tatyana G.; Sukhodolskaya, Galina V.; Nikolayeva, Vera M.; Baskunov, Boris P.; Turchin, K: 'Hydroxylation of carbazoles by Aspergillus flavus VKM F-1024' FEMS Microbiology Letters 235(1), 2004, 51-56 * |
JPN6015019352; Sharma, R. B.; Seth, Mrs. Renu; Anwer, Falak; Kapil, R. S.: 'Synthesis of mupamine' Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry 20B(8), 1981, 701-2 * |
JPN6015019353; Ramesh, K.; Kapil, R. S.: 'A facile synthesis of carbazole-1,4-quinones' Chemistry & Industry (London, United Kingdom) , 1986, 614-15 * |
JPN6015019354; Kusano, Genjiro; Shibano, Makio; Idoji, Mayumi; Minoura, Katsuhiko: 'A new alkaloid, 2-hydroxy-7-methyl-9H-carbazole from Cimicifuga simplex' Heterocycles 36(10), 1993, 2367-71 * |
JPN6015019355; Kureel, S. P.; Kapil, R. S.; Popli, Satya P.: 'Synthesis of koenine, koenimbine, and girinimbine' Chemistry & Industry (London, United Kingdom) (39), 1970, 1262 * |
JPN6015019358; Anwer, F.; Kapil, R. S.; Popli, S. P.: 'Terpenoid alkaloids from Murraya koenigii. VII. Synthesis of DL-O-methylmahanine and related carba' Experientia 28(7), 1972, 769 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170076091A (en) * | 2015-12-24 | 2017-07-04 | (주)아모레퍼시픽 | Salicylic acid derivative compounds, preparation method thereof, and whitening cosmetic composition comprising the same |
KR102463237B1 (en) | 2015-12-24 | 2022-11-04 | (주)아모레퍼시픽 | Salicylic acid derivative compounds, preparation method thereof, and whitening cosmetic composition comprising the same |
CN118126050A (en) * | 2024-05-06 | 2024-06-04 | 云南省肿瘤医院(昆明医科大学第三附属医院) | 6-Methoxy carbazole alkaloid compound and preparation method and application thereof |
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