JPH0781997B2 - 液体クロマトグラフィー用球状充填剤 - Google Patents
液体クロマトグラフィー用球状充填剤Info
- Publication number
- JPH0781997B2 JPH0781997B2 JP61158411A JP15841186A JPH0781997B2 JP H0781997 B2 JPH0781997 B2 JP H0781997B2 JP 61158411 A JP61158411 A JP 61158411A JP 15841186 A JP15841186 A JP 15841186A JP H0781997 B2 JPH0781997 B2 JP H0781997B2
- Authority
- JP
- Japan
- Prior art keywords
- filler
- liquid chromatography
- packing material
- calcium phosphate
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000463 material Substances 0.000 title claims description 12
- 238000004811 liquid chromatography Methods 0.000 title claims description 7
- 238000012856 packing Methods 0.000 title claims description 7
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 claims description 4
- 239000000945 filler Substances 0.000 description 19
- 239000001506 calcium phosphate Substances 0.000 description 11
- 229910000389 calcium phosphate Inorganic materials 0.000 description 11
- 235000011010 calcium phosphates Nutrition 0.000 description 11
- 239000011575 calcium Substances 0.000 description 10
- 238000000926 separation method Methods 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- -1 calcium phosphate compound Chemical class 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 150000008163 sugars Chemical class 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 229960004793 sucrose Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 235000013681 dietary sucrose Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000000635 electron micrograph Methods 0.000 description 2
- 238000010304 firing Methods 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/04—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
- B01J20/048—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium containing phosphorus, e.g. phosphates, apatites, hydroxyapatites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
- B01J20/28019—Spherical, ellipsoidal or cylindrical
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61158411A JPH0781997B2 (ja) | 1986-07-05 | 1986-07-05 | 液体クロマトグラフィー用球状充填剤 |
| SE8702760A SE466836B (sv) | 1986-07-05 | 1987-07-03 | Sfaeriskt fyllningsmaterial foer vaetskekromatografi, foerfarande foer framstaellning av fyllningsmaterialet och anvaendning av detta vid vaetskekromatografi |
| DE19873722103 DE3722103A1 (de) | 1986-07-05 | 1987-07-03 | Kugelfoermiges fuellmaterial zur fluessigchromatografie |
| US07/461,854 US5039408A (en) | 1986-07-05 | 1990-01-08 | Packing material for liquid chromatography |
| US08/029,940 US5441635A (en) | 1986-07-05 | 1993-03-10 | Packing material for liquid chromatography |
| US08/105,850 USRE35340E (en) | 1986-07-05 | 1993-08-13 | Packing material for liquid chromatography |
| US08/371,378 US5651882A (en) | 1986-07-05 | 1995-01-11 | Packing material for liquid chromatography and process for producing the same |
| US08/371,205 US6306297B1 (en) | 1968-07-08 | 1995-01-11 | Packing material for liquid chromatography and process for producing the same |
| US08/469,731 US5651884A (en) | 1986-07-05 | 1995-06-06 | Packing material for liquid chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61158411A JPH0781997B2 (ja) | 1986-07-05 | 1986-07-05 | 液体クロマトグラフィー用球状充填剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6316046A JPS6316046A (ja) | 1988-01-23 |
| JPH0781997B2 true JPH0781997B2 (ja) | 1995-09-06 |
Family
ID=15671166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61158411A Expired - Lifetime JPH0781997B2 (ja) | 1968-07-08 | 1986-07-05 | 液体クロマトグラフィー用球状充填剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPH0781997B2 (en:Method) |
| DE (1) | DE3722103A1 (en:Method) |
| SE (1) | SE466836B (en:Method) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5039408A (en) * | 1986-07-05 | 1991-08-13 | Asahi Kogaku Kogyo K.K. | Packing material for liquid chromatography |
| JPS6413453A (en) * | 1987-07-08 | 1989-01-18 | Asahi Optical Co Ltd | Packing agent for liquid chromatography |
| US5441635A (en) * | 1986-07-05 | 1995-08-15 | Asahi Kogaku Kogyo Kabushiki Kaisha | Packing material for liquid chromatography |
| USRE35340E (en) * | 1986-07-05 | 1996-10-01 | Asahi Kogaku Kogyo K.K. | Packing material for liquid chromatography |
| JPH01162148A (ja) * | 1987-12-18 | 1989-06-26 | Asahi Optical Co Ltd | 液体クロマトグラフィー用充填剤およびその製法 |
| JPH01218579A (ja) * | 1988-02-25 | 1989-08-31 | Sekisui Plastics Co Ltd | ウイスキーの脱色剤 |
| US5728463A (en) * | 1992-08-07 | 1998-03-17 | Kanto Kagaku Kabushiki Kaisha | Stationary phase material for chromatography |
| EP0607459B1 (en) * | 1992-08-07 | 2002-03-20 | Kanto Kagaku Kabushiki Kaisha | Use of a solid material as a stationary phase for chromatography |
| JP5463537B2 (ja) * | 2008-02-22 | 2014-04-09 | ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 | 分離方法 |
| WO2021163910A1 (en) * | 2020-02-19 | 2021-08-26 | Bio-Rad Laboratories, Inc. | Method of preparing polymer-filled chromatography resin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0762674B2 (ja) * | 1986-03-07 | 1995-07-05 | 株式会社高研 | クロマトグラフイ−用吸着剤、及びその製造方法、並びに該吸着剤を使用したクロマトグラフイ−カラム |
-
1986
- 1986-07-05 JP JP61158411A patent/JPH0781997B2/ja not_active Expired - Lifetime
-
1987
- 1987-07-03 DE DE19873722103 patent/DE3722103A1/de active Granted
- 1987-07-03 SE SE8702760A patent/SE466836B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3722103A1 (de) | 1988-01-14 |
| DE3722103C2 (en:Method) | 1991-10-17 |
| SE466836B (sv) | 1992-04-13 |
| SE8702760D0 (sv) | 1987-07-03 |
| SE8702760L (sv) | 1988-01-06 |
| JPS6316046A (ja) | 1988-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |