JPH07506960A - ヒト甲状腺ペルオキシダーゼに特異的な疾病関連性ヒト抗体 - Google Patents

ヒト甲状腺ペルオキシダーゼに特異的な疾病関連性ヒト抗体

Info

Publication number
JPH07506960A
JPH07506960A JP5505362A JP50536293A JPH07506960A JP H07506960 A JPH07506960 A JP H07506960A JP 5505362 A JP5505362 A JP 5505362A JP 50536293 A JP50536293 A JP 50536293A JP H07506960 A JPH07506960 A JP H07506960A
Authority
JP
Japan
Prior art keywords
tpo
antibody
cells
human
human thyroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5505362A
Other languages
English (en)
Japanese (ja)
Inventor
ラポポート，バシル
Original Assignee
ニコルス・インスティチュート・ダイアグノスティクス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1992/006283 external-priority patent/WO1993003146A1/en
Application filed by ニコルス・インスティチュート・ダイアグノスティクス filed Critical ニコルス・インスティチュート・ダイアグノスティクス
Publication of JPH07506960A publication Critical patent/JPH07506960A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP5505362A 1991-08-28 1992-08-28 ヒト甲状腺ペルオキシダーゼに特異的な疾病関連性ヒト抗体 Pending JPH07506960A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75057991A 1991-08-28 1991-08-28
US750,579 1991-08-28
WO92/06283 1992-07-30
PCT/US1992/006283 WO1993003146A1 (en) 1991-07-30 1992-07-30 Disease associated b-cell epitopes of tpo and use thereof
PCT/US1992/007381 WO1993005072A1 (en) 1991-08-28 1992-08-28 Disease associated human autoantibodies specific for human thyroid peroxidase

Publications (1)

Publication Number Publication Date
JPH07506960A true JPH07506960A (ja) 1995-08-03

Family

ID=26784910

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5505362A Pending JPH07506960A (ja) 1991-08-28 1992-08-28 ヒト甲状腺ペルオキシダーゼに特異的な疾病関連性ヒト抗体

Country Status (8)

Country Link
US (1) US7196181B1 (show.php)
EP (1) EP0668918A1 (show.php)
JP (1) JPH07506960A (show.php)
AU (1) AU2555792A (show.php)
CA (1) CA2116453A1 (show.php)
FI (1) FI940732A7 (show.php)
NO (1) NO940668D0 (show.php)
WO (1) WO1993005072A1 (show.php)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI940732A7 (fi) 1991-08-28 1994-04-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasille spesifiset autovasta-aineet
GB2265713A (en) * 1992-05-16 1993-10-06 R S R Limited Assay for autoantibodies against thyroglobulin or thyroid peroxidase
JP2007501011A (ja) * 2003-08-01 2007-01-25 ジェネンテック・インコーポレーテッド 制限多様性配列を有する結合型ポリペプチド
GB0621513D0 (en) * 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof
CN105087512A (zh) * 2014-05-13 2015-11-25 苏州偲聚生物材料有限公司 可用于检测甲状腺疾病的蛋白质及该蛋白质的部分肽
EP4470553A3 (en) 2018-07-02 2024-12-11 Siemens Healthcare Diagnostics Inc. Novel thyroid peroxidase autoantibody immunoassay

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
NZ209308A (en) * 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
WO1991002061A1 (en) * 1989-07-31 1991-02-21 Basil Rapaport Recombinant human thyroid peroxidase
CA2024562C (en) 1989-09-05 2000-09-26 Shinya Yamashita Cho cells transformed with a recombinant plasmid expressing human thyroid peroxidase and preparation thereof
FI940391A7 (fi) * 1991-07-30 1994-03-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasin B-soluepitoopit ja niiden käyttö
FI940732A7 (fi) 1991-08-28 1994-04-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasille spesifiset autovasta-aineet
US5998153A (en) 1992-05-19 1999-12-07 The Regents Of The University Of Michigan Thyroid peroxidase epitopic regions
GB9622772D0 (en) 1996-11-01 1997-01-08 Rsr Ltd Monitoring reactivity of thyroid peroxidase autoantibodies

Also Published As

Publication number Publication date
FI940732L (fi) 1994-04-28
FI940732A0 (fi) 1994-02-16
NO940668D0 (no) 1994-02-25
EP0668918A1 (en) 1995-08-30
AU2555792A (en) 1993-04-05
CA2116453A1 (en) 1993-03-18
NO940668L (show.php) 1994-04-29
EP0668918A4 (en) 1994-11-28
FI940732A7 (fi) 1994-04-28
US7196181B1 (en) 2007-03-27
WO1993005072A1 (en) 1993-03-18

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