JPH07503540A - 半定量結合検定用校正試薬および装置 - Google Patents
半定量結合検定用校正試薬および装置Info
- Publication number
- JPH07503540A JPH07503540A JP5513247A JP51324793A JPH07503540A JP H07503540 A JPH07503540 A JP H07503540A JP 5513247 A JP5513247 A JP 5513247A JP 51324793 A JP51324793 A JP 51324793A JP H07503540 A JPH07503540 A JP H07503540A
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- complex
- reagent
- test sample
- immobilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
- G01N33/54389—Immunochromatographic test strips based on lateral flow with bidirectional or multidirectional lateral flow, e.g. wherein the sample flows from a single, common sample application point into multiple strips, lanes or zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/971—Capture of complex after antigen-antibody reaction
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82348692A | 1992-01-22 | 1992-01-22 | |
| US823,486 | 1992-01-22 | ||
| PCT/US1993/000174 WO1993015230A1 (en) | 1992-01-22 | 1993-01-07 | Calibration reagents for semi-quantitative binding assays and devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07503540A true JPH07503540A (ja) | 1995-04-13 |
Family
ID=25238904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5513247A Pending JPH07503540A (ja) | 1992-01-22 | 1993-01-07 | 半定量結合検定用校正試薬および装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5780308A (OSRAM) |
| EP (1) | EP0643777A4 (OSRAM) |
| JP (1) | JPH07503540A (OSRAM) |
| AU (1) | AU3439693A (OSRAM) |
| CA (1) | CA2128320A1 (OSRAM) |
| TW (1) | TW273010B (OSRAM) |
| WO (1) | WO1993015230A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009058507A (ja) * | 2007-09-01 | 2009-03-19 | Inverness Medical Switzerland Gmbh | 共有ゾーンを有する分析デバイス |
| JP2015508180A (ja) * | 2012-02-21 | 2015-03-16 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | バイオアッセイのシグナル増幅のための方法およびシステム |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308775A (en) * | 1992-09-15 | 1994-05-03 | Abbott Laboratories | Assay devices for concurrently detecting an analyte and confirming the test result |
| JP3479100B2 (ja) * | 1993-06-02 | 2003-12-15 | 帝国臓器製薬株式会社 | 免疫化学的簡易半定量方法および装置 |
| US5521102A (en) * | 1994-08-08 | 1996-05-28 | Quidel Corporation | Controlled sensitivity immunochromatographic assay |
| GB2300914B (en) * | 1995-04-28 | 1998-04-29 | Tepnel Medical Ltd | Analytical device |
| AUPN527995A0 (en) * | 1995-09-07 | 1995-09-28 | Agen Biomedical Limited | Method and apparatus for semiquantification of an analyte |
| EP0888552A1 (en) * | 1996-03-20 | 1999-01-07 | Serex, Inc. | Chromatographic immunoassay device and method utilizing particle valency for quantitation |
| EP1701164B1 (en) * | 1997-07-16 | 2009-03-11 | Charm Sciences Inc. | Method for detecting the presence of a residue analyte in a sample |
| US6436721B1 (en) * | 1997-07-25 | 2002-08-20 | Bayer Corporation | Device and method for obtaining clinically significant analyte ratios |
| EP0982590B1 (en) * | 1998-07-01 | 2003-11-19 | Nitto Denko Corporation | Labeled conjugate and detection method using the same |
| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| AU2261601A (en) * | 1999-12-15 | 2001-06-25 | Icogen Corporation | Method for the simultaneous analysis and detection of multiple analytes by microidentification |
| JP2001349892A (ja) * | 2000-04-03 | 2001-12-21 | Unilever Nv | 検査方法及びデバイス |
| DE10035451C2 (de) * | 2000-07-19 | 2002-12-05 | November Ag Molekulare Medizin | Verfahren und Vorrichtung zur Identifizierung einer Polymersequenz |
| WO2002033418A1 (en) * | 2000-10-17 | 2002-04-25 | Besst-Test Aps | Assay for directly detecting a biological cell in a body fluid sample |
| EP1361435A4 (en) * | 2001-09-28 | 2005-01-26 | Matsushita Electric Industrial Co Ltd | ANALYZER AND PROCESS FOR SPECIFIC BINDING |
| US20030113823A1 (en) * | 2001-10-11 | 2003-06-19 | Gregory Richard L. | Diagnostic assays for determination of dental caries susceptibility |
| US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
| US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US8367013B2 (en) | 2001-12-24 | 2013-02-05 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
| US20040018576A1 (en) * | 2002-07-24 | 2004-01-29 | Dematteo Todd M. | Bence Jones protein testing cassette |
| US7314763B2 (en) | 2002-08-27 | 2008-01-01 | Kimberly-Clark Worldwide, Inc. | Fluidics-based assay devices |
| US7432105B2 (en) | 2002-08-27 | 2008-10-07 | Kimberly-Clark Worldwide, Inc. | Self-calibration system for a magnetic binding assay |
| US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
| US7700372B2 (en) | 2002-10-08 | 2010-04-20 | Tara Nylese | Portable diagnostic device and method for determining temporal variations in concentrations |
| US7247500B2 (en) | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
| US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
| US20040197819A1 (en) | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
| US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
| US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
| US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
| US7410808B1 (en) * | 2003-12-08 | 2008-08-12 | Charm Sciences, Inc. | Method and assay for detection of residues |
| US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
| AU2003300109A1 (en) * | 2003-12-30 | 2005-08-03 | Calypte Biomedical Corporation | Rapid test for antibodies against hiv in urine |
| US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
| US20060019406A1 (en) * | 2004-07-23 | 2006-01-26 | Ning Wei | Lateral flow device for the detection of large pathogens |
| US20060068500A1 (en) * | 2004-09-28 | 2006-03-30 | Kimberly-Clark Worldwide, Inc. | Detecting yeast infections using a lateral flow assay |
| US7396689B2 (en) * | 2005-02-04 | 2008-07-08 | Decision Biomarkers Incorporated | Method of adjusting the working range of a multi-analyte assay |
| US7439079B2 (en) * | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| US20070020699A1 (en) * | 2005-07-19 | 2007-01-25 | Idexx Laboratories, Inc. | Lateral flow assay and device using magnetic particles |
| CN101191847A (zh) | 2006-12-01 | 2008-06-04 | 鸿富锦精密工业（深圳）有限公司 | 光学板 |
| BRPI0914367A2 (pt) | 2008-10-29 | 2019-09-24 | Kci Licensing Inc | sistema do fechamento de ferimento com pressão reduzida modular para gerar uma força de fechamento em uma ferimento de superfície em um paciente, método de fabricação de um sistema de fechamento de ferimento com pressão reduzida modular para gerar um força de fechamento em um ferumnento de superfície em um paciente, método para gerar uma força de fechamento em um ferimento de superfície em um paciente, e, sistema de tratamento e fechmaneto de ferimento com pressão reduzida para prover uma força de fechamento a um ferimento de superfície e para aplicar a pressão reduzida a um local do tecido. |
| CA2800460A1 (en) * | 2009-04-28 | 2010-11-11 | Innovative Laboratory Technologies, Inc. | Lateral-flow immuno-chromatographic assay devices |
| EP2566949B1 (en) | 2010-05-06 | 2023-02-15 | Charm Sciences, Inc. | Reader-incubator apparatus |
| US20160349252A1 (en) * | 2015-05-29 | 2016-12-01 | Polymer Technology Systems, Inc. | Systems and methods for combined vertical/lateral flow blood separation technologies with enablement of point-of-care cotinine detection with extended range |
| KR20160140186A (ko) * | 2015-05-29 | 2016-12-07 | 삼성전자주식회사 | 분석용 스트립, 분석용 스트립을 이용한 장치 및 시스템 |
| US11119102B1 (en) | 2016-02-16 | 2021-09-14 | Charm Sciences, Inc. | Test device, method, and assembly |
| CN110275029B (zh) * | 2019-07-30 | 2024-09-10 | 南通伊仕生物技术股份有限公司 | 一种人绒毛膜促性腺激素半定量检测试纸、试剂杯及其制备方法和应用 |
| US20230042375A1 (en) * | 2022-09-20 | 2023-02-09 | Marvin Liu | Membrane based chemiluminescence immunochromatography assay and its use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2118455B1 (de) * | 1971-04-16 | 1972-09-21 | Boehringer Mannheim Gmbh | Teststreifen |
| US3915639A (en) * | 1973-10-18 | 1975-10-28 | Robert M Friedenberg | Drug abuse dipstick |
| SE388694B (sv) * | 1975-01-27 | 1976-10-11 | Kabi Ab | Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar |
| US4059407A (en) * | 1976-04-14 | 1977-11-22 | Becton, Dickinson And Company | Disposable chemical indicators |
| US4094647A (en) * | 1976-07-02 | 1978-06-13 | Thyroid Diagnostics, Inc. | Test device |
| US4235601A (en) * | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4361537A (en) * | 1979-01-12 | 1982-11-30 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4378428A (en) * | 1981-03-30 | 1983-03-29 | Baker Instruments Corporation | Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays |
| US4551308A (en) * | 1981-07-09 | 1985-11-05 | International Technidyne Corp. | Apparatus for analyzing the influence of additive reagents upon the coagulation of blood and related methods |
| US5073484A (en) * | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
| US4435504A (en) * | 1982-07-15 | 1984-03-06 | Syva Company | Immunochromatographic assay with support having bound "MIP" and second enzyme |
| US4536479A (en) * | 1983-03-22 | 1985-08-20 | E. I. Du Pont De Nemours And Company | Use of anti-idiotype antibodies in immunoassays |
| US4594327A (en) * | 1983-11-02 | 1986-06-10 | Syntex (U.S.A.) Inc. | Assay method for whole blood samples |
| US4703017C1 (en) * | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| US4757004A (en) * | 1984-03-16 | 1988-07-12 | Syntex (U.S.A.) Inc. | Chromatographic devices having modified edges |
| DE3445816C1 (de) * | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| EP0207152B1 (en) * | 1984-12-20 | 1992-12-30 | Nycomed Pharma As | Solid phase diffusion assay |
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| US4806311A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having labeled reagent concentration zone |
| US4806312A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having detectable signal concentrating zone |
| US4689309A (en) * | 1985-09-30 | 1987-08-25 | Miles Laboratories, Inc. | Test device, method of manufacturing same and method of determining a component in a sample |
| US4868108A (en) * | 1985-12-12 | 1989-09-19 | Hygeia Sciences, Incorporated | Multiple-antibody detection of antigen |
| US4960691A (en) * | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| EP0271204A3 (en) * | 1986-11-07 | 1989-10-25 | Syntex (U.S.A.) Inc. | Immunochromatographic method and device |
| CA1303983C (en) * | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| US4956275A (en) * | 1987-04-14 | 1990-09-11 | Molecular Devices Corporation | Migratory detection immunoassay |
| DE560410T1 (de) * | 1987-04-27 | 2001-12-20 | Unilever Nv | Testgerät zur Durchführung von spezifischen Bindungsprüfungen. |
| US4943522A (en) * | 1987-06-01 | 1990-07-24 | Quidel | Lateral flow, non-bibulous membrane assay protocols |
| US4956302A (en) * | 1987-09-11 | 1990-09-11 | Abbott Laboratories | Lateral flow chromatographic binding assay device |
| CA1339723C (en) * | 1988-01-19 | 1998-03-17 | Philip Mcmahon | Immunoassay with multiple test spots |
| US4952517A (en) * | 1988-02-08 | 1990-08-28 | Hygeia Sciences, Inc. | Positive step immunoassay |
| US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| WO1992005282A1 (en) * | 1990-09-14 | 1992-04-02 | Biosite Diagnostics, Inc. | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5395754A (en) * | 1992-07-31 | 1995-03-07 | Hybritech Incorporated | Membrane-based immunoassay method |
-
1993
- 1993-01-07 JP JP5513247A patent/JPH07503540A/ja active Pending
- 1993-01-07 WO PCT/US1993/000174 patent/WO1993015230A1/en not_active Ceased
- 1993-01-07 AU AU34396/93A patent/AU3439693A/en not_active Abandoned
- 1993-01-07 CA CA002128320A patent/CA2128320A1/en not_active Abandoned
- 1993-01-07 EP EP93903040A patent/EP0643777A4/en not_active Ceased
- 1993-02-02 TW TW082100687A patent/TW273010B/zh active
-
1997
- 1997-05-12 US US08/854,785 patent/US5780308A/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009058507A (ja) * | 2007-09-01 | 2009-03-19 | Inverness Medical Switzerland Gmbh | 共有ゾーンを有する分析デバイス |
| JP2015508180A (ja) * | 2012-02-21 | 2015-03-16 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | バイオアッセイのシグナル増幅のための方法およびシステム |
Also Published As
| Publication number | Publication date |
|---|---|
| TW273010B (OSRAM) | 1996-03-21 |
| AU3439693A (en) | 1993-09-01 |
| US5780308A (en) | 1998-07-14 |
| CA2128320A1 (en) | 1993-08-05 |
| EP0643777A1 (en) | 1995-03-22 |
| EP0643777A4 (en) | 1995-06-07 |
| WO1993015230A1 (en) | 1993-08-05 |
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