JPH07501764A - 高い屈折率のヒドロゲル及びその使用 - Google Patents
高い屈折率のヒドロゲル及びその使用Info
- Publication number
- JPH07501764A JPH07501764A JP6509201A JP50920194A JPH07501764A JP H07501764 A JPH07501764 A JP H07501764A JP 6509201 A JP6509201 A JP 6509201A JP 50920194 A JP50920194 A JP 50920194A JP H07501764 A JPH07501764 A JP H07501764A
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- hydrogel
- lens
- vinylpyridine
- refractive index
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000017 hydrogel Substances 0.000 title claims description 84
- 229920000642 polymer Polymers 0.000 claims description 89
- 238000000034 method Methods 0.000 claims description 79
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- 239000000178 monomer Substances 0.000 claims description 26
- 229920006037 cross link polymer Polymers 0.000 claims description 25
- 230000005489 elastic deformation Effects 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 22
- KANZWHBYRHQMKZ-UHFFFAOYSA-N 2-ethenylpyrazine Chemical compound C=CC1=CN=CC=N1 KANZWHBYRHQMKZ-UHFFFAOYSA-N 0.000 claims description 18
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 16
- UMKWZZPKADNTRP-UHFFFAOYSA-N 4-ethenylpyrimidine Chemical compound C=CC1=CC=NC=N1 UMKWZZPKADNTRP-UHFFFAOYSA-N 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 13
- HCLJOFJIQIJXHS-UHFFFAOYSA-N 2-[2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOCCOC(=O)C=C HCLJOFJIQIJXHS-UHFFFAOYSA-N 0.000 claims description 12
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 claims description 10
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims description 9
- LEJBBGNFPAFPKQ-UHFFFAOYSA-N 2-(2-prop-2-enoyloxyethoxy)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOC(=O)C=C LEJBBGNFPAFPKQ-UHFFFAOYSA-N 0.000 claims description 8
- JASFBLBUHWKFBZ-UHFFFAOYSA-N 2-Methyl-5-vinylpyrazine Chemical compound CC1=CN=C(C=C)C=N1 JASFBLBUHWKFBZ-UHFFFAOYSA-N 0.000 claims description 8
- DPZYLEIWHTWHCU-UHFFFAOYSA-N 3-ethenylpyridine Chemical compound C=CC1=CC=CN=C1 DPZYLEIWHTWHCU-UHFFFAOYSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- 238000003780 insertion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 5
- 208000002847 Surgical Wound Diseases 0.000 claims description 3
- YERHJBPPDGHCRJ-UHFFFAOYSA-N 1-[4-(1-oxoprop-2-enyl)-1-piperazinyl]-2-propen-1-one Chemical compound C=CC(=O)N1CCN(C(=O)C=C)CC1 YERHJBPPDGHCRJ-UHFFFAOYSA-N 0.000 claims description 2
- CAXDVRWCYBTEPM-UHFFFAOYSA-N 5-ethenyl-2-methylpyrimidine Chemical compound CC1=NC=C(C=C)C=N1 CAXDVRWCYBTEPM-UHFFFAOYSA-N 0.000 claims description 2
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims 4
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 230000036571 hydration Effects 0.000 description 24
- 238000006703 hydration reaction Methods 0.000 description 24
- 239000000463 material Substances 0.000 description 24
- 238000002513 implantation Methods 0.000 description 23
- 229920001577 copolymer Polymers 0.000 description 20
- 230000003287 optical effect Effects 0.000 description 14
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 10
- 230000009477 glass transition Effects 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 9
- 238000006116 polymerization reaction Methods 0.000 description 9
- 238000001356 surgical procedure Methods 0.000 description 9
- 230000008961 swelling Effects 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 5
- VOCDJQSAMZARGX-UHFFFAOYSA-N 1-ethenylpyrrolidine-2,5-dione Chemical compound C=CN1C(=O)CCC1=O VOCDJQSAMZARGX-UHFFFAOYSA-N 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 150000004677 hydrates Chemical class 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- 208000037386 Typhoid Diseases 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 229910003460 diamond Inorganic materials 0.000 description 3
- 239000010432 diamond Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- -1 methacrylate Heterocyclic compounds Chemical class 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 201000008297 typhoid fever Diseases 0.000 description 3
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- SFPNZPQIIAJXGL-UHFFFAOYSA-N 2-ethoxyethyl 2-methylprop-2-enoate Chemical compound CCOCCOC(=O)C(C)=C SFPNZPQIIAJXGL-UHFFFAOYSA-N 0.000 description 2
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002390 heteroarenes Chemical class 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- WUIJTQZXUURFQU-UHFFFAOYSA-N 1-methylsulfonylethene Chemical compound CS(=O)(=O)C=C WUIJTQZXUURFQU-UHFFFAOYSA-N 0.000 description 1
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 1
- LNUXXIMFIDHHRB-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COCCOC(=O)C(C)=C LNUXXIMFIDHHRB-UHFFFAOYSA-N 0.000 description 1
- NRKBLMPVZVTOBN-UHFFFAOYSA-N 2-methyl-n-(pyridin-3-ylmethyl)prop-2-enamide Chemical compound CC(=C)C(=O)NCC1=CC=CN=C1 NRKBLMPVZVTOBN-UHFFFAOYSA-N 0.000 description 1
- ZFBLHIJEHRNYOI-UHFFFAOYSA-N 2-methylprop-2-enoic acid propane-1,2,3-triol prop-2-enamide Chemical compound OCC(O)CO.C(C=C)(=O)N.C(C(=C)C)(=O)O ZFBLHIJEHRNYOI-UHFFFAOYSA-N 0.000 description 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000364051 Pima Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 206010036346 Posterior capsule opacification Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 208000028104 epidemic louse-borne typhus Diseases 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 206010061393 typhus Diseases 0.000 description 1
- 239000003190 viscoelastic substance Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/02—Artificial eyes from organic plastic material
- B29D11/023—Implants for natural eyes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16905—Having means on lens to reduce overall dimension of lens for insertion into small incision
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
- A61F2210/0019—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Eyeglasses (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims (42)
- 1.3−ビニルピリジン、4−ビニルピリジン、4−ビニルピリミジン、ビニル ピラジン、及び2−メチル−5−ビニルピラジンより成る群から選択される1以 上のモノマーから製造される架橋されたポリマーを含んで成るヒドロゲル。
- 2.ジエチレングリコールジアクリレート、テトラエチレングリコールジアクリ レート、及び1,4−ジアクリロイルピペラジンより成る群から選択される1以 上のモノマーが架橋剤として採用される、請求項1記載のヒドロゲル。
- 3.N−ビニルイミダゾールを含んで成るモノマ−並びに3−ビニルビリジン、 4−ビニルピリジン、4−ビニルピリミジン、ビニルピラジン、及び2−メチル −5−ビニルピラジンより成る群から選択される少なくとも1つのコモノマーの 混合物から製造される架橋されたポリマーを含んで成るヒドロゲル。
- 4.N−ビニルイミダゾール、4−ビニルピリミジン、及びビニルピリジンを含 んで成るモノマーの混合物から製造される架橋されたポリマーを含んで成るヒド ロゲル。
- 5.N−ビニルピロリドンを含んで成るモノマー並びに3−ビニルピリジン、4 −ビニルピリジン、4−ビニルピリミジン、ビニルピラジン、及び2−メチル− 5−ビニルピラジンより成る群から選択される少なくとも1つのコモノマーの混 合物から製造される架橋されたポリマーを含んで成るヒドロゲル。
- 6.N−ビニルビロリドン、4−ビニルピリミジン、及びビニルピリジンを含ん で成るモノマーの混合物から製造される架橋されたポリマーを含んで成るヒドロ ゲル。
- 7.N−ビニルピロリドン及び4−ビニルピリミジンを含んで成るモノマーの混 合物から製造される架橋されたポリマーを含んで成るヒドロゲル。
- 8.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範囲 の屈折率nD20を有する、請求項1記載のヒドロゲル。
- 9.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範囲 の屈折率nD20を有する、請求項2記載のヒドロゲル。
- 10.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範 囲の屈折率nD20を有する、請求項3記載のヒドロゲル。
- 11.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範 囲の屈折率nD20を有する、請求項4記載のヒドロゲル。
- 12.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範 囲の屈折率nD20を有する、請求項5記載のヒドロゲル。
- 13.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範 囲の屈折率nD20を有する、請求項6記載のヒドロゲル。
- 14.前記架橋されたポリマーが乾燥状態において1.560〜1.594の範 囲の屈折率nD20を有する、請求項7記載のヒドロゲル。
- 15.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項8記載のヒドロゲル。
- 16.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項9記載のヒドロゲル。
- 17.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項10記載のヒドロゲル。
- 18.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項11記載のヒドロゲル。
- 19.前記架橋されたポリマーが水和された平衝水含量約57%〜90%を有す る、請求項12記載のヒドロゲル。
- 20.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項13記載のヒドロゲル。
- 21.前記架橋されたポリマーが水和された平衡水含量約57%〜90%を有す る、請求項14記載のヒドロゲル。
- 22.小切開挿入のための減じられた大きさを有する膨張性ヒドロゲル眼内レン ズの製造方法であって、次の: 脱水された寸法を有する脱水されたヒドロゲル眼内レンズを提供する工程、ただ し前記脱水されたヒドロゲル眼内レンズが3−ビニルピリジン、4−ビニルピリ ジン、4−ビニルピリミジン、ビニルピラジン、及び2−メチル−5−ビニルピ ラジンより成る群から選択される1以上のモノマーから製造される架橋されたポ リマーから成り、かつ弾性変形温度を有する;少なくとも前記弾性変形温度と同 じ高さの温度において前記脱水されたヒドロゲル眼内レンズを変形して、前記脱 水され変形されたレンズを4mmの外科切開を通じて移動するのに十分に前記脱 水された寸法が減じられた状態に変形された形態を提供する工程;及び 前記変形され脱水された眼内レンズを前記弾性変形温度より十分に下の温度に冷 却させて、前記変形され脱水された眼内レンズをその変形された形態に凝固させ る工程 を含んで成る前記の方法。
- 23.ジエチレングリコールジアクリレート、テトラエチレングリコールジアク リレート、及び1,4−ジアクリロイルピペラジンより成る群から選択される1 以上のモノマーが架橋剤として採用される、請求項22記載の方法。
- 24.前記ポリマーが、N−ビニルイミダゾールを含んで成るモノマー並びに3 −ビニルピリジン、4−ビニルピリジン、4−ビニルピリミジン、ビニルピラジ ン、及び2−メチル−5−ビニルピラジンより成る群から選択される少なくとも 1つのコモノマーの混合物から製造される、請求項22記載の方法。
- 25.前記ポリマーが、N−ビニルイミダゾール、4−ビニルピリミジン、及び ビニルピリジンを含んで成るモノマーの混合物から製造される、請求項22記載 の方法。
- 26.前記ポリマーが、N−ビニルピロリドンを含んで成るモノマー並びに3− ビニルピリジン、4−ビニルピリジン、4−ビニルピリミジン、ビニルピラジン 、及び2−メチル−5−ビニルピラジンより成る群から選択される少なくとも1 つのコモノマーの混合物から製造される、請求項22記載の方法。
- 27.前記ポリマーが、N−ビニルピロリドン、4−ビニルピリミジン、及びビ ニルピリジンを含んで成るモノマーの混合物から製造される、請求項22記載の 方法。
- 28.前記ポリマーが、N−ビニルピロリドン及び4−ビニルピリミジンを含ん で成るモノマーの混合物から製造される、請求項22記載の方法。
- 29.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項22記載の方法。
- 30.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項23記載の方法。
- 31.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項24記載の方法。
- 32.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項25記載の方法。
- 33.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項26記載の方法。
- 34.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 nD20を有する、請求項27記載の方法。
- 35.前記ポリマーが乾燥状態において1.560〜1.594の範囲の屈折率 no20を有する、請求項28記載の方法。
- 36.前記ポリマーが平衡水含量約57%〜90%を有する、請求項29記載の 方法。
- 37.前記ポリマーが平衡水含量約57%〜90%を有する、請求項30記載の 方法。
- 38.前記ポリマーが平衡水含量約57%〜90%を有する、請求項31記載の 方法。
- 39.前記ポリマーが平衡水含量約57%〜90%を有する、請求項32記載の 方法。
- 40.前記ポリマーが平衡水含量約57%〜90%を有する、請求項33記載の 方法。
- 41.前記ポリマーが平衡水含量約57%〜90%を有する、請求項34記載の 方法。
- 42.前記ポリマーが平衡水含量約57%〜90%を有する、請求項35記載の 方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07951775 US5316704B1 (en) | 1992-09-28 | 1992-09-28 | Process for fabricating full sized expansible hydrogel intraocular lenses |
US951,775 | 1992-09-28 | ||
US08/096,932 US5480950A (en) | 1992-09-28 | 1993-07-23 | High refractive index hydrogels and uses thereof |
US096,932 | 1993-07-23 | ||
PCT/US1993/009121 WO1994007686A1 (en) | 1992-09-28 | 1993-09-24 | High refractive index hydrogels and uses thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2003104234A Division JP3980510B2 (ja) | 1992-09-28 | 2003-04-08 | 高い屈折率のヒドロゲル及びその使用 |
Publications (2)
Publication Number | Publication Date |
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JPH07501764A true JPH07501764A (ja) | 1995-02-23 |
JP3544975B2 JP3544975B2 (ja) | 2004-07-21 |
Family
ID=26792218
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP50920194A Expired - Lifetime JP3544975B2 (ja) | 1992-09-28 | 1993-09-24 | 高い屈折率のヒドロゲル及びその使用 |
JP2003104234A Expired - Fee Related JP3980510B2 (ja) | 1992-09-28 | 2003-04-08 | 高い屈折率のヒドロゲル及びその使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2003104234A Expired - Fee Related JP3980510B2 (ja) | 1992-09-28 | 2003-04-08 | 高い屈折率のヒドロゲル及びその使用 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5480950A (ja) |
EP (1) | EP0621824A4 (ja) |
JP (2) | JP3544975B2 (ja) |
AU (1) | AU669224B2 (ja) |
CA (1) | CA2124326A1 (ja) |
FI (1) | FI942483A (ja) |
NO (1) | NO941975L (ja) |
WO (1) | WO1994007686A1 (ja) |
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1993
- 1993-07-23 US US08/096,932 patent/US5480950A/en not_active Expired - Lifetime
- 1993-09-24 JP JP50920194A patent/JP3544975B2/ja not_active Expired - Lifetime
- 1993-09-24 EP EP93922387A patent/EP0621824A4/en not_active Withdrawn
- 1993-09-24 CA CA002124326A patent/CA2124326A1/en not_active Abandoned
- 1993-09-24 WO PCT/US1993/009121 patent/WO1994007686A1/en not_active Application Discontinuation
- 1993-09-24 AU AU51400/93A patent/AU669224B2/en not_active Expired - Fee Related
-
1994
- 1994-05-27 NO NO941975A patent/NO941975L/no unknown
- 1994-05-27 FI FI942483A patent/FI942483A/fi not_active Application Discontinuation
-
2003
- 2003-04-08 JP JP2003104234A patent/JP3980510B2/ja not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008053810A1 (fr) * | 2006-10-30 | 2008-05-08 | Mitsui Chemicals, Inc. | Gel sensible au ph, procédé de fabrication dudit gel, et soupape sensible au ph |
Also Published As
Publication number | Publication date |
---|---|
NO941975L (no) | 1994-07-25 |
JP3544975B2 (ja) | 2004-07-21 |
EP0621824A1 (en) | 1994-11-02 |
JP2003290335A (ja) | 2003-10-14 |
JP3980510B2 (ja) | 2007-09-26 |
FI942483A (fi) | 1994-06-06 |
FI942483A0 (fi) | 1994-05-27 |
CA2124326A1 (en) | 1994-04-14 |
WO1994007686A1 (en) | 1994-04-14 |
US5480950A (en) | 1996-01-02 |
AU669224B2 (en) | 1996-05-30 |
EP0621824A4 (en) | 1995-03-22 |
AU5140093A (en) | 1994-04-26 |
NO941975D0 (no) | 1994-05-27 |
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