JPH07285997A - Ｔｎｆ変異タンパク質 - Google Patents

Ｔｎｆ変異タンパク質

Info

Publication number
JPH07285997A
JPH07285997A JP5075445A JP7544593A JPH07285997A JP H07285997 A JPH07285997 A JP H07285997A JP 5075445 A JP5075445 A JP 5075445A JP 7544593 A JP7544593 A JP 7544593A JP H07285997 A JPH07285997 A JP H07285997A
Authority
JP
Japan
Prior art keywords
tnfα
thr
tnf
mutein
mutant protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5075445A
Other languages
English (en)
Japanese (ja)
Inventor
Werner Lesslauer
レスラオアー ヴェルナー
Hansruedi Loetscher
レットシャー ハンスルエディ
Dietrich Stueber
スチューバー ディートリッヒ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPH07285997A publication Critical patent/JPH07285997A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP5075445A 1992-04-02 1993-04-01 Ｔｎｆ変異タンパク質 Pending JPH07285997A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH92810249:0 1992-04-02
EP92810249 1992-04-02

Publications (1)

Publication Number Publication Date
JPH07285997A true JPH07285997A (ja) 1995-10-31

Family

ID=8211902

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5075445A Pending JPH07285997A (ja) 1992-04-02 1993-04-01 Ｔｎｆ変異タンパク質

Country Status (19)

Country Link
US (1) US5486463A (forum.php)
EP (1) EP0563714A3 (forum.php)
JP (1) JPH07285997A (forum.php)
CN (1) CN1037844C (forum.php)
AU (1) AU659927B2 (forum.php)
BR (1) BR9301420A (forum.php)
CA (1) CA2091313A1 (forum.php)
CZ (1) CZ283533B6 (forum.php)
FI (1) FI931488L (forum.php)
HU (1) HUT69790A (forum.php)
IL (1) IL105170A0 (forum.php)
MX (1) MX9301700A (forum.php)
NO (1) NO931141L (forum.php)
NZ (1) NZ247265A (forum.php)
PL (1) PL298345A1 (forum.php)
SK (1) SK376492A3 (forum.php)
TW (1) TW260707B (forum.php)
UY (1) UY23561A1 (forum.php)
ZA (1) ZA932177B (forum.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005066206A1 (ja) * 2004-01-06 2008-01-17 株式会社林原生物化学研究所 Ｔｎｆアンタゴニスト及びそれを有効成分とするｔｎｆ阻害剤

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
CN1049663C (zh) * 1994-09-01 2000-02-23 中国科学院上海生物工程研究中心 突变的人肿瘤坏死因子
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
PT1255558E (pt) * 2000-02-16 2006-11-30 Genentech Inc Anticorpos anti-april e células hibridoma
HUP0500992A3 (en) * 2001-08-03 2007-11-28 Genentech Inc Tacis and br3 polypeptides and uses thereof
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20030199024A1 (en) * 2002-04-19 2003-10-23 Hansen Ted H. Single chain trimers of class I MHC molecules
WO2004011611A2 (en) * 2002-07-25 2004-02-05 Genentech, Inc. Taci antibodies and uses thereof
MXPA05005921A (es) * 2002-12-02 2005-10-19 Abgenix Inc Anticuerpos dirigidos a factor de necrosis tumoral y sus usos.
US20040121971A1 (en) * 2002-12-20 2004-06-24 Gang Chen Therapeutic use of tumor necrosis factor-alpha mutein
JP2007536896A (ja) * 2003-06-05 2007-12-20 ジェネンテック・インコーポレーテッド Ｂｌｙｓアンタゴニストとその用途
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
CN100390200C (zh) * 2003-11-24 2008-05-28 中国医学科学院基础医学研究所 一种用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
CN1752211B (zh) * 2004-09-23 2010-09-15 中国医学科学院基础医学研究所 用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
US20070065514A1 (en) * 2005-09-22 2007-03-22 Howell Mark D Method for enhancing immune responses in mammals
CA2629306A1 (en) * 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US8518697B2 (en) * 2006-04-04 2013-08-27 Washington University Single chain trimers and uses therefor
US20100316626A1 (en) * 2006-08-11 2010-12-16 The Government Of The United States Of America As Represented By The Secretary Methods for treatment and diagnosis of psychiatric disorders
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
PL2953634T3 (pl) 2013-02-07 2021-11-22 The General Hospital Corporation Sposoby namnażania lub zubożania limfocytów t-regulatorowych
US11224858B1 (en) 2020-10-01 2022-01-18 Immunicom, Inc. Reduced leaching of a ligand
CA3194403A1 (en) 2020-10-01 2022-04-07 Steven Josephs Reduced leaching of a ligand
WO2025163107A1 (en) 2024-02-01 2025-08-07 Institut Gustave Roussy Immune cells defective for znf217 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005066206A1 (ja) * 2004-01-06 2008-01-17 株式会社林原生物化学研究所 Ｔｎｆアンタゴニスト及びそれを有効成分とするｔｎｆ阻害剤
JP2011057680A (ja) * 2004-01-06 2011-03-24 Hayashibara Biochem Lab Inc Ｔｎｆアンタゴニスト及びそれを有効成分とするｔｎｆ阻害剤
US7993636B2 (en) 2004-01-06 2011-08-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Tumor necrosis factor-alpha mutants
US8187584B2 (en) 2004-01-06 2012-05-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Human tumor necrosis factor-α mutants

Also Published As

Publication number Publication date
ZA932177B (en) 1993-10-04
SK376492A3 (en) 1995-06-07
CA2091313A1 (en) 1993-10-03
HUT69790A (en) 1995-09-28
CN1037844C (zh) 1998-03-25
IL105170A0 (en) 1993-07-08
CZ376492A3 (en) 1994-01-19
BR9301420A (pt) 1993-10-05
FI931488A7 (fi) 1993-10-03
NZ247265A (en) 1995-10-26
PL298345A1 (en) 1993-12-27
MX9301700A (es) 1993-10-29
NO931141D0 (no) 1993-03-26
NO931141L (no) 1993-10-04
HU9300843D0 (en) 1993-06-28
FI931488A0 (fi) 1993-04-01
AU659927B2 (en) 1995-06-01
UY23561A1 (es) 1993-09-20
FI931488L (fi) 1993-10-03
EP0563714A2 (en) 1993-10-06
CZ283533B6 (cs) 1998-04-15
TW260707B (forum.php) 1995-10-21
US5486463A (en) 1996-01-23
AU3561193A (en) 1993-10-07
EP0563714A3 (en) 1993-11-10
CN1079225A (zh) 1993-12-08

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