PL298345A1 - Muteines of tumor necrotic factor /tnf/, dna sequence including muteine encoding dna, vector, method of obtaining tnf muteine and pharmaceutical preparation - Google Patents

Muteines of tumor necrotic factor /tnf/, dna sequence including muteine encoding dna, vector, method of obtaining tnf muteine and pharmaceutical preparation

Info

Publication number
PL298345A1
PL298345A1 PL29834593A PL29834593A PL298345A1 PL 298345 A1 PL298345 A1 PL 298345A1 PL 29834593 A PL29834593 A PL 29834593A PL 29834593 A PL29834593 A PL 29834593A PL 298345 A1 PL298345 A1 PL 298345A1
Authority
PL
Poland
Prior art keywords
muteine
tnf
muteines
vector
obtaining
Prior art date
Application number
PL29834593A
Other languages
English (en)
Inventor
Werner Lesslauer
Hansruedi Loetscher
Dietrich Stueber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL298345A1 publication Critical patent/PL298345A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL29834593A 1992-04-02 1993-04-01 Muteines of tumor necrotic factor /tnf/, dna sequence including muteine encoding dna, vector, method of obtaining tnf muteine and pharmaceutical preparation PL298345A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92810249 1992-04-02

Publications (1)

Publication Number Publication Date
PL298345A1 true PL298345A1 (en) 1993-12-27

Family

ID=8211902

Family Applications (1)

Application Number Title Priority Date Filing Date
PL29834593A PL298345A1 (en) 1992-04-02 1993-04-01 Muteines of tumor necrotic factor /tnf/, dna sequence including muteine encoding dna, vector, method of obtaining tnf muteine and pharmaceutical preparation

Country Status (19)

Country Link
US (1) US5486463A (forum.php)
EP (1) EP0563714A3 (forum.php)
JP (1) JPH07285997A (forum.php)
CN (1) CN1037844C (forum.php)
AU (1) AU659927B2 (forum.php)
BR (1) BR9301420A (forum.php)
CA (1) CA2091313A1 (forum.php)
CZ (1) CZ283533B6 (forum.php)
FI (1) FI931488L (forum.php)
HU (1) HUT69790A (forum.php)
IL (1) IL105170A0 (forum.php)
MX (1) MX9301700A (forum.php)
NO (1) NO931141L (forum.php)
NZ (1) NZ247265A (forum.php)
PL (1) PL298345A1 (forum.php)
SK (1) SK376492A3 (forum.php)
TW (1) TW260707B (forum.php)
UY (1) UY23561A1 (forum.php)
ZA (1) ZA932177B (forum.php)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
CN1049663C (zh) * 1994-09-01 2000-02-23 中国科学院上海生物工程研究中心 突变的人肿瘤坏死因子
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
PT1255558E (pt) * 2000-02-16 2006-11-30 Genentech Inc Anticorpos anti-april e células hibridoma
HUP0500992A3 (en) * 2001-08-03 2007-11-28 Genentech Inc Tacis and br3 polypeptides and uses thereof
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20030199024A1 (en) * 2002-04-19 2003-10-23 Hansen Ted H. Single chain trimers of class I MHC molecules
WO2004011611A2 (en) * 2002-07-25 2004-02-05 Genentech, Inc. Taci antibodies and uses thereof
MXPA05005921A (es) * 2002-12-02 2005-10-19 Abgenix Inc Anticuerpos dirigidos a factor de necrosis tumoral y sus usos.
US20040121971A1 (en) * 2002-12-20 2004-06-24 Gang Chen Therapeutic use of tumor necrosis factor-alpha mutein
JP2007536896A (ja) * 2003-06-05 2007-12-20 ジェネンテック・インコーポレーテッド Ｂｌｙｓアンタゴニストとその用途
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
CN100390200C (zh) * 2003-11-24 2008-05-28 中国医学科学院基础医学研究所 一种用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
TW201122103A (en) 2004-01-06 2011-07-01 Hayashibara Biochem Lab Tnf antagonists and tnf inhibitors comprising the same as the active ingredient
CN1752211B (zh) * 2004-09-23 2010-09-15 中国医学科学院基础医学研究所 用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
US20070065514A1 (en) * 2005-09-22 2007-03-22 Howell Mark D Method for enhancing immune responses in mammals
CA2629306A1 (en) * 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US8518697B2 (en) * 2006-04-04 2013-08-27 Washington University Single chain trimers and uses therefor
US20100316626A1 (en) * 2006-08-11 2010-12-16 The Government Of The United States Of America As Represented By The Secretary Methods for treatment and diagnosis of psychiatric disorders
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
PL2953634T3 (pl) 2013-02-07 2021-11-22 The General Hospital Corporation Sposoby namnażania lub zubożania limfocytów t-regulatorowych
US11224858B1 (en) 2020-10-01 2022-01-18 Immunicom, Inc. Reduced leaching of a ligand
CA3194403A1 (en) 2020-10-01 2022-04-07 Steven Josephs Reduced leaching of a ligand
WO2025163107A1 (en) 2024-02-01 2025-08-07 Institut Gustave Roussy Immune cells defective for znf217 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins

Also Published As

Publication number Publication date
ZA932177B (en) 1993-10-04
SK376492A3 (en) 1995-06-07
CA2091313A1 (en) 1993-10-03
HUT69790A (en) 1995-09-28
CN1037844C (zh) 1998-03-25
IL105170A0 (en) 1993-07-08
CZ376492A3 (en) 1994-01-19
BR9301420A (pt) 1993-10-05
FI931488A7 (fi) 1993-10-03
NZ247265A (en) 1995-10-26
JPH07285997A (ja) 1995-10-31
MX9301700A (es) 1993-10-29
NO931141D0 (no) 1993-03-26
NO931141L (no) 1993-10-04
HU9300843D0 (en) 1993-06-28
FI931488A0 (fi) 1993-04-01
AU659927B2 (en) 1995-06-01
UY23561A1 (es) 1993-09-20
FI931488L (fi) 1993-10-03
EP0563714A2 (en) 1993-10-06
CZ283533B6 (cs) 1998-04-15
TW260707B (forum.php) 1995-10-21
US5486463A (en) 1996-01-23
AU3561193A (en) 1993-10-07
EP0563714A3 (en) 1993-11-10
CN1079225A (zh) 1993-12-08

Similar Documents

Publication Publication Date Title
PL298345A1 (en) Muteines of tumor necrotic factor /tnf/, dna sequence including muteine encoding dna, vector, method of obtaining tnf muteine and pharmaceutical preparation
EP0183350A3 (en) Dna endcoding human colony stimulating factor, peptide encoded thereby,vectors and transformed hosts containing such dna, and the production of all thereof
EP0155549A3 (en) Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
EP0260610A3 (en) Monoclonal antibodies against human tumour necrotic factor (tnf), and their use
CS39586A3 (en) Peptide derivatives, process of their preparation and use
SG77892G (en) Human tumor necrosis factor and dna therefor
SK4395A3 (en) Parathormone derivatives, method of their production and pharmaceutical preparations containing this derivatives
KR960700752A (ko) 광범위한 종양억제 유전자와 유전자 생성물 그리고 종양억제 유전자 요법의 방법
CZ54295A3 (en) Beads, process of their preparation and pharmaceutical dosing forms based thereon
NZ227177A (en) Vectors and dna compounds for the expression of human protein c
PL297870A1 (en) Substituted sulfonylbenzylopyridones as well as method of obtaining and drugs containing them
EP0574267A3 (en) Preparation of nucleic acid from blood
EP0693931A4 (en) IMMUNOGENIC PROTEINS AND PEPTIDES OF CANCER AND METHOD OF USE
NZ237198A (en) Zymogen form of protein c, dna, vector and use as a pharmaceutical
AU5847194A (en) Novel entomopoxvirus genes, proteins and methods of use thereof
IL96253A0 (en) Modified forms of human erythropoietin and dna sequences encoding genes which can express them
ZA86936B (en) 11beta-phenyl-gonanes,their manufacture and pharmaceutical preparations containing them
IL73569A (en) Dna-sequences encoding modified eglins,vectors containing such dna sequences,hosts transformed by the vectors,modified eglin polypeptides produced by the transformed hosts,methods for the preparation of the dna sequences,vectors and transformed hosts,processes for the preparation of modified eglins utilizing the transformed hosts and pharmaceutical products containing the modified eglins
IL81026A0 (en) Peptides for immunizing against plasmodium falciparum,dna molecules coding for them and compositions containing said peptides
EP0409893A4 (en) Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
ZA961050B (en) Substituted benzenesulfonylureas and -thioureas processes for their preparation their use for the production of pharmaceutical preparations and pharmaceutical preparations containing them
DE3463518D1 (en) Preparations of easily dispersible isoindoline pigments and their use
AU1875592A (en) Amino acid sequence of anticancer human monoclonal antibody and dna base sequence coding for the same
EP0378676A4 (en) Tumor necrosis enhancing factor and methods of preparation and use
PL252062A1 (en) Method of obtaining pharmaceutical preparations exibiting prolonged therapeutic action