JPH06506685A - 新規な非抗凝固剤ヘパリン誘導体 - Google Patents
新規な非抗凝固剤ヘパリン誘導体Info
- Publication number
- JPH06506685A JPH06506685A JP4509700A JP50970092A JPH06506685A JP H06506685 A JPH06506685 A JP H06506685A JP 4509700 A JP4509700 A JP 4509700A JP 50970092 A JP50970092 A JP 50970092A JP H06506685 A JPH06506685 A JP H06506685A
- Authority
- JP
- Japan
- Prior art keywords
- heparin
- periodate
- oxidized
- nac
- antiproliferative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US753,299 | 1985-07-10 | ||
| US67740691A | 1991-03-29 | 1991-03-29 | |
| US677,406 | 1991-03-29 | ||
| US07/753,299 US5280016A (en) | 1991-03-29 | 1991-09-03 | Non-anticoagulant heparin derivatives |
| PCT/US1992/002516 WO1992017187A1 (en) | 1991-03-29 | 1992-03-27 | New non-anticoagulant heparin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06506685A true JPH06506685A (ja) | 1994-07-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP4509700A Pending JPH06506685A (ja) | 1991-03-29 | 1992-03-27 | 新規な非抗凝固剤ヘパリン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5280016A (enExample) |
| EP (1) | EP0577756A1 (enExample) |
| JP (1) | JPH06506685A (enExample) |
| AU (1) | AU1763892A (enExample) |
| CA (1) | CA2107362A1 (enExample) |
| NO (1) | NO933470L (enExample) |
| WO (1) | WO1992017187A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000344674A (ja) * | 1999-03-31 | 2000-12-12 | Seikagaku Kogyo Co Ltd | 血管内皮細胞増殖因子作用の抑制剤及び血管新生の抑制剤 |
| JP2003523460A (ja) * | 2000-01-25 | 2003-08-05 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 抗脈管形成活性を有し、かつ、抗凝固作用がない、部分脱硫酸グリコサミノグリカンの誘導体 |
| JP2012163560A (ja) * | 2011-02-07 | 2012-08-30 | Siemens Healthcare Diagnostics Products Gmbh | 直接的凝固因子阻害剤を決定するためのへパリン非感受性方法 |
| JP2015500387A (ja) * | 2011-12-19 | 2015-01-05 | ディラフォレッテ アクチエボラゲット | 低抗凝固剤ヘパリン |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
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| DE3519011A1 (de) * | 1985-05-25 | 1986-11-27 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines materials zur affinitaetschromatographie |
| US4883751A (en) * | 1986-05-28 | 1989-11-28 | New York University | Specific immunoassay for heparin |
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| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5032679A (en) * | 1988-12-15 | 1991-07-16 | Glycomed, Inc. | Heparin fragments as inhibitors of smooth muscle cell proliferation |
-
1991
- 1991-09-03 US US07/753,299 patent/US5280016A/en not_active Expired - Fee Related
-
1992
- 1992-03-27 AU AU17638/92A patent/AU1763892A/en not_active Abandoned
- 1992-03-27 EP EP92910644A patent/EP0577756A1/en not_active Withdrawn
- 1992-03-27 CA CA002107362A patent/CA2107362A1/en not_active Abandoned
- 1992-03-27 JP JP4509700A patent/JPH06506685A/ja active Pending
- 1992-03-27 WO PCT/US1992/002516 patent/WO1992017187A1/en not_active Ceased
-
1993
- 1993-09-28 NO NO93933470A patent/NO933470L/no unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000344674A (ja) * | 1999-03-31 | 2000-12-12 | Seikagaku Kogyo Co Ltd | 血管内皮細胞増殖因子作用の抑制剤及び血管新生の抑制剤 |
| JP2003523460A (ja) * | 2000-01-25 | 2003-08-05 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 抗脈管形成活性を有し、かつ、抗凝固作用がない、部分脱硫酸グリコサミノグリカンの誘導体 |
| JP2012163560A (ja) * | 2011-02-07 | 2012-08-30 | Siemens Healthcare Diagnostics Products Gmbh | 直接的凝固因子阻害剤を決定するためのへパリン非感受性方法 |
| JP2015500387A (ja) * | 2011-12-19 | 2015-01-05 | ディラフォレッテ アクチエボラゲット | 低抗凝固剤ヘパリン |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992017187A1 (en) | 1992-10-15 |
| CA2107362A1 (en) | 1992-09-30 |
| US5280016A (en) | 1994-01-18 |
| NO933470D0 (no) | 1993-09-28 |
| EP0577756A1 (en) | 1994-01-12 |
| EP0577756A4 (enExample) | 1994-02-09 |
| AU1763892A (en) | 1992-11-02 |
| NO933470L (no) | 1993-10-19 |
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