JPH06506206A - コラゲナーゼ阻害剤としてのチオールカルボン酸誘導体 - Google Patents

コラゲナーゼ阻害剤としてのチオールカルボン酸誘導体

Info

Publication number
JPH06506206A
JPH06506206A JP4507179A JP50717992A JPH06506206A JP H06506206 A JPH06506206 A JP H06506206A JP 4507179 A JP4507179 A JP 4507179A JP 50717992 A JP50717992 A JP 50717992A JP H06506206 A JPH06506206 A JP H06506206A
Authority
JP
Japan
Prior art keywords
formula
hydrogen
compound
alkyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4507179A
Other languages
English (en)
Japanese (ja)
Inventor
マークウェル，ロジャー・エドワード
ウォード，ロバート・ウイリアム
ラトクリフ，スティーブン・ジョン
Original Assignee
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー filed Critical スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Publication of JPH06506206A publication Critical patent/JPH06506206A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP4507179A 1991-04-08 1992-04-06 コラゲナーゼ阻害剤としてのチオールカルボン酸誘導体 Pending JPH06506206A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9107367.6 1991-04-08
GB919107367A GB9107367D0 (en) 1991-04-08 1991-04-08 Novel compounds
PCT/GB1992/000612 WO1992017444A1 (fr) 1991-04-08 1992-04-06 Derives d'acide thiol-carboxylique a titre d'inhibiteurs de collagenase

Publications (1)

Publication Number Publication Date
JPH06506206A true JPH06506206A (ja) 1994-07-14

Family

ID=10692842

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4507179A Pending JPH06506206A (ja) 1991-04-08 1992-04-06 コラゲナーゼ阻害剤としてのチオールカルボン酸誘導体

Country Status (12)

Country Link
EP (1) EP0579648A1 (fr)
JP (1) JPH06506206A (fr)
AU (1) AU1456792A (fr)
CA (1) CA2107334A1 (fr)
GB (1) GB9107367D0 (fr)
IE (1) IE921100A1 (fr)
MX (1) MX9201575A (fr)
NZ (1) NZ242240A (fr)
PT (1) PT100353A (fr)
TW (1) TW210333B (fr)
WO (1) WO1992017444A1 (fr)
ZA (1) ZA922501B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
GB8729804D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
GB9107367D0 (en) 1991-05-22
IE921100A1 (en) 1992-10-21
MX9201575A (es) 1993-08-01
ZA922501B (en) 1993-10-07
AU1456792A (en) 1992-11-02
PT100353A (pt) 1993-06-30
CA2107334A1 (fr) 1992-10-09
WO1992017444A1 (fr) 1992-10-15
NZ242240A (en) 1993-11-25
EP0579648A1 (fr) 1994-01-26
TW210333B (fr) 1993-08-01

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