MX9201575A - Compuestos novedosos. - Google Patents
Compuestos novedosos.Info
- Publication number
- MX9201575A MX9201575A MX9201575A MX9201575A MX9201575A MX 9201575 A MX9201575 A MX 9201575A MX 9201575 A MX9201575 A MX 9201575A MX 9201575 A MX9201575 A MX 9201575A MX 9201575 A MX9201575 A MX 9201575A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- alkyl
- alkoxy
- hydrogen
- nr6r7
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen compuestos novedosos de la fórmula general (I), procedimientos para su preparación, y su uso como inhibidores de colagenasa, en donde R1 es -OH; alcoxi, ariloxi, aralquiloxi; -NR6R7, en donde cada R6 y R7 independientemente hidrógeno o alquilo, o R6 y R7 junto con el átomo de nitrógeno al cual están unidos forman un anillo de 5, 6 o 7 miembros con un átomo adicional de oxígeno, azufre o nitrógeno opcionalmente substituido en el anillo; o un grupo: fórmula (II) en donde R8 es hidrógeno; alquilo opcionalmente substituido por -OH, alcoxi, -NR6 R7, guanidina , -CO2H, CONH2, SH o S- alquilo; o CH2 en donde Ar es arilo opcionalmente substituido; y R6 es alcoxi; OH; o -NR6R7; R2 es hidrógeno, o acilo, tal como -CO-alquilo o -C-ZO, en donde Z es arilo opcionalmente susbtituido; R3 es alquilo de C3-6; R4 es -(CH2_)nNR10R11, -(CH2)nNHCOR12, (CH2)nNR13(NR14)NR10R11, (CH2)nCONH(CH2)09N10R11 o-(CH2)n.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919107367A GB9107367D0 (en) | 1991-04-08 | 1991-04-08 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9201575A true MX9201575A (es) | 1993-08-01 |
Family
ID=10692842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9201575A MX9201575A (es) | 1991-04-08 | 1992-04-06 | Compuestos novedosos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0579648A1 (es) |
JP (1) | JPH06506206A (es) |
AU (1) | AU1456792A (es) |
CA (1) | CA2107334A1 (es) |
GB (1) | GB9107367D0 (es) |
IE (1) | IE921100A1 (es) |
MX (1) | MX9201575A (es) |
NZ (1) | NZ242240A (es) |
PT (1) | PT100353A (es) |
TW (1) | TW210333B (es) |
WO (1) | WO1992017444A1 (es) |
ZA (1) | ZA922501B (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1322073C (en) * | 1986-12-24 | 1993-09-07 | Roger E. Markwell | Thiol-carboxylic acid derivatives |
GB8729804D0 (en) * | 1987-12-22 | 1988-02-03 | Beecham Group Plc | Novel compounds |
-
1991
- 1991-04-08 GB GB919107367A patent/GB9107367D0/en active Pending
-
1992
- 1992-04-06 JP JP4507179A patent/JPH06506206A/ja active Pending
- 1992-04-06 CA CA002107334A patent/CA2107334A1/en not_active Abandoned
- 1992-04-06 WO PCT/GB1992/000612 patent/WO1992017444A1/en not_active Application Discontinuation
- 1992-04-06 AU AU14567/92A patent/AU1456792A/en not_active Abandoned
- 1992-04-06 EP EP92907683A patent/EP0579648A1/en not_active Ceased
- 1992-04-06 NZ NZ242240A patent/NZ242240A/xx unknown
- 1992-04-06 MX MX9201575A patent/MX9201575A/es unknown
- 1992-04-07 TW TW081102615A patent/TW210333B/zh active
- 1992-04-07 IE IE110092A patent/IE921100A1/en unknown
- 1992-04-07 PT PT100353A patent/PT100353A/pt not_active Application Discontinuation
- 1992-04-07 ZA ZA922501A patent/ZA922501B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2107334A1 (en) | 1992-10-09 |
GB9107367D0 (en) | 1991-05-22 |
WO1992017444A1 (en) | 1992-10-15 |
JPH06506206A (ja) | 1994-07-14 |
IE921100A1 (en) | 1992-10-21 |
NZ242240A (en) | 1993-11-25 |
ZA922501B (en) | 1993-10-07 |
EP0579648A1 (en) | 1994-01-26 |
AU1456792A (en) | 1992-11-02 |
PT100353A (pt) | 1993-06-30 |
TW210333B (es) | 1993-08-01 |
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