CA2107334A1 - Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase - Google Patents

Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase

Info

Publication number
CA2107334A1
CA2107334A1 CA002107334A CA2107334A CA2107334A1 CA 2107334 A1 CA2107334 A1 CA 2107334A1 CA 002107334 A CA002107334 A CA 002107334A CA 2107334 A CA2107334 A CA 2107334A CA 2107334 A1 CA2107334 A1 CA 2107334A1
Authority
CA
Canada
Prior art keywords
formula
hydrogen
alkyl
compound
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002107334A
Other languages
English (en)
Inventor
Roger Edward Markwell
Robert William Ward
Steven John Ratcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2107334A1 publication Critical patent/CA2107334A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002107334A 1991-04-08 1992-04-06 Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase Abandoned CA2107334A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9107367.6 1991-04-08
GB919107367A GB9107367D0 (en) 1991-04-08 1991-04-08 Novel compounds

Publications (1)

Publication Number Publication Date
CA2107334A1 true CA2107334A1 (fr) 1992-10-09

Family

ID=10692842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002107334A Abandoned CA2107334A1 (fr) 1991-04-08 1992-04-06 Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase

Country Status (12)

Country Link
EP (1) EP0579648A1 (fr)
JP (1) JPH06506206A (fr)
AU (1) AU1456792A (fr)
CA (1) CA2107334A1 (fr)
GB (1) GB9107367D0 (fr)
IE (1) IE921100A1 (fr)
MX (1) MX9201575A (fr)
NZ (1) NZ242240A (fr)
PT (1) PT100353A (fr)
TW (1) TW210333B (fr)
WO (1) WO1992017444A1 (fr)
ZA (1) ZA922501B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
GB8729804D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
GB9107367D0 (en) 1991-05-22
IE921100A1 (en) 1992-10-21
MX9201575A (es) 1993-08-01
JPH06506206A (ja) 1994-07-14
ZA922501B (en) 1993-10-07
AU1456792A (en) 1992-11-02
PT100353A (pt) 1993-06-30
WO1992017444A1 (fr) 1992-10-15
NZ242240A (en) 1993-11-25
EP0579648A1 (fr) 1994-01-26
TW210333B (fr) 1993-08-01

Similar Documents

Publication Publication Date Title
US4692458A (en) Anti-hypertensive agents
AU599736B2 (en) Thiol-carboxylic acid derivatives
EP1200457B1 (fr) Inhibiteurs de cysteine protease
HU211287A9 (en) Hydroxamic acid derivatives as metalloproteinase inhibitors
EP0579650A1 (fr) Nouveaux composes
WO1991015487A1 (fr) Nouveau derive de 4-1-benzoxazine-4h-3,1
EP0859784B1 (fr) Peptides thio-substitues utiles comme inhibiteurs de metalloproteases et de la liberation du tnf
AU642046B2 (en) N-(2-alkyl-3-mercaptoglutaryl)-amino-diaza cycloalkanone derivatives and their use as collagenase inhibitors
IE910097A1 (en) Novel compounds
US5124322A (en) Dipeptide collagenase inhibitors
AU634383B2 (en) Phosphonopeptides with collagenase inhibiting activity
AU637903B2 (en) Phosphonopeptides with collagenase inhibiting activity
CA2107334A1 (fr) Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase
US4734420A (en) Anti-hypertensive agents
CA1295333C (fr) Composes acylaminoalcanoyles
US4690936A (en) Anti-hypertensive agents
MXPA97007214A (en) Derivatives of hydroxamic acid containing lactama, compositions containing them and using the mis
MXPA01006719A (en) Selective inhibitors of mmp-12
ZA200308590B (en) Dipeptide derivatives having a n-terminal 2-thiocyl group as vasopeptidase inhibitors.

Legal Events

Date Code Title Description
FZDE Dead