CA2107334A1 - Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase - Google Patents

Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase

Info

Publication number
CA2107334A1
CA2107334A1 CA002107334A CA2107334A CA2107334A1 CA 2107334 A1 CA2107334 A1 CA 2107334A1 CA 002107334 A CA002107334 A CA 002107334A CA 2107334 A CA2107334 A CA 2107334A CA 2107334 A1 CA2107334 A1 CA 2107334A1
Authority
CA
Canada
Prior art keywords
formula
hydrogen
alkyl
compound
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002107334A
Other languages
English (en)
Inventor
Roger Edward Markwell
Robert William Ward
Steven John Ratcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2107334A1 publication Critical patent/CA2107334A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/20Esters of monothiocarboxylic acids
    • C07C327/32Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002107334A 1991-04-08 1992-04-06 Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase Abandoned CA2107334A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9107367.6 1991-04-08
GB919107367A GB9107367D0 (en) 1991-04-08 1991-04-08 Novel compounds

Publications (1)

Publication Number Publication Date
CA2107334A1 true CA2107334A1 (fr) 1992-10-09

Family

ID=10692842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002107334A Abandoned CA2107334A1 (fr) 1991-04-08 1992-04-06 Derives d'acide thiolcarboxylique utilises comme inhibiteurs de la collagenase

Country Status (12)

Country Link
EP (1) EP0579648A1 (fr)
JP (1) JPH06506206A (fr)
AU (1) AU1456792A (fr)
CA (1) CA2107334A1 (fr)
GB (1) GB9107367D0 (fr)
IE (1) IE921100A1 (fr)
MX (1) MX9201575A (fr)
NZ (1) NZ242240A (fr)
PT (1) PT100353A (fr)
TW (1) TW210333B (fr)
WO (1) WO1992017444A1 (fr)
ZA (1) ZA922501B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
GB8729804D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
GB9107367D0 (en) 1991-05-22
IE921100A1 (en) 1992-10-21
MX9201575A (es) 1993-08-01
JPH06506206A (ja) 1994-07-14
ZA922501B (en) 1993-10-07
AU1456792A (en) 1992-11-02
PT100353A (pt) 1993-06-30
WO1992017444A1 (fr) 1992-10-15
NZ242240A (en) 1993-11-25
EP0579648A1 (fr) 1994-01-26
TW210333B (fr) 1993-08-01

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Legal Events

Date Code Title Description
FZDE Dead