ZA922501B - Thid-carboxylic acid derivatives as collagenase inhibitors. - Google Patents

Thid-carboxylic acid derivatives as collagenase inhibitors.

Info

Publication number
ZA922501B
ZA922501B ZA922501A ZA922501A ZA922501B ZA 922501 B ZA922501 B ZA 922501B ZA 922501 A ZA922501 A ZA 922501A ZA 922501 A ZA922501 A ZA 922501A ZA 922501 B ZA922501 B ZA 922501B
Authority
ZA
South Africa
Prior art keywords
thid
carboxylic acid
acid derivatives
collagenase inhibitors
collagenase
Prior art date
Application number
ZA922501A
Other languages
English (en)
Inventor
Roger Edward Markwell
Robert William Ward
Steven John Ratcliffe
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA922501B publication Critical patent/ZA922501B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA922501A 1991-04-08 1992-04-07 Thid-carboxylic acid derivatives as collagenase inhibitors. ZA922501B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919107367A GB9107367D0 (en) 1991-04-08 1991-04-08 Novel compounds

Publications (1)

Publication Number Publication Date
ZA922501B true ZA922501B (en) 1993-10-07

Family

ID=10692842

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA922501A ZA922501B (en) 1991-04-08 1992-04-07 Thid-carboxylic acid derivatives as collagenase inhibitors.

Country Status (12)

Country Link
EP (1) EP0579648A1 (fr)
JP (1) JPH06506206A (fr)
AU (1) AU1456792A (fr)
CA (1) CA2107334A1 (fr)
GB (1) GB9107367D0 (fr)
IE (1) IE921100A1 (fr)
MX (1) MX9201575A (fr)
NZ (1) NZ242240A (fr)
PT (1) PT100353A (fr)
TW (1) TW210333B (fr)
WO (1) WO1992017444A1 (fr)
ZA (1) ZA922501B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
GB8729804D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
GB9107367D0 (en) 1991-05-22
IE921100A1 (en) 1992-10-21
MX9201575A (es) 1993-08-01
JPH06506206A (ja) 1994-07-14
AU1456792A (en) 1992-11-02
PT100353A (pt) 1993-06-30
CA2107334A1 (fr) 1992-10-09
WO1992017444A1 (fr) 1992-10-15
NZ242240A (en) 1993-11-25
EP0579648A1 (fr) 1994-01-26
TW210333B (fr) 1993-08-01

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