JPH0641464B2 - ジヒドロピリジン類 - Google Patents
ジヒドロピリジン類Info
- Publication number
- JPH0641464B2 JPH0641464B2 JP60118702A JP11870285A JPH0641464B2 JP H0641464 B2 JPH0641464 B2 JP H0641464B2 JP 60118702 A JP60118702 A JP 60118702A JP 11870285 A JP11870285 A JP 11870285A JP H0641464 B2 JPH0641464 B2 JP H0641464B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- halo
- compound according
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8414520 | 1984-06-07 | ||
| GB848414520A GB8414520D0 (en) | 1984-06-07 | 1984-06-07 | Dihydropyridines |
| GB858508736A GB8508736D0 (en) | 1985-04-03 | 1985-04-03 | Dihydropyridines |
| GB8508736 | 1985-04-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS611685A JPS611685A (ja) | 1986-01-07 |
| JPH0641464B2 true JPH0641464B2 (ja) | 1994-06-01 |
Family
ID=26287832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60118702A Expired - Lifetime JPH0641464B2 (ja) | 1984-06-07 | 1985-05-31 | ジヒドロピリジン類 |
Country Status (14)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412208D0 (en) * | 1984-05-12 | 1984-06-20 | Pfizer Ltd | Quinolone inotropic agents |
| AU593278B2 (en) * | 1985-08-06 | 1990-02-08 | Boehringer Mannheim Italia S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| US4761420A (en) * | 1986-06-13 | 1988-08-02 | Laboratoires Syntex S.A. | Antihypertensive dihydropyridine derivatives |
| US4920134A (en) * | 1987-08-07 | 1990-04-24 | Takeda Chemical Industries, Ltd. | 2-O-pyrimidinyl glycerol derivatives |
| US5424321A (en) * | 1993-12-08 | 1995-06-13 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
| US5691360A (en) * | 1993-12-08 | 1997-11-25 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
| EP3081214A3 (en) | 2003-08-29 | 2016-11-16 | The Brigham And Women's Hospital, Inc. | Inhibitors of cellular necrosis |
| WO2010075290A1 (en) * | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
| JP2012513481A (ja) | 2008-12-23 | 2012-06-14 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ネクロトーシスの小分子阻害剤 |
| US20160024098A1 (en) | 2013-03-15 | 2016-01-28 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
| TW201632516A (zh) | 2014-12-11 | 2016-09-16 | 哈佛大學校長及研究員協會 | 細胞壞死抑制劑與相關方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2951945A1 (de) * | 1979-12-22 | 1981-07-02 | Ibm Deutschland Gmbh, 7000 Stuttgart | Schaltungsanordnung zur kapazitiven lesesignalverstaerkung in einem integrierten halbleiterspeicher mit einem intergrierten halbleiterspeicher mit speicherzellen in mtl-technik |
| EP0100189B1 (en) * | 1982-07-22 | 1986-05-28 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
| PT77842B (en) * | 1982-12-21 | 1986-05-05 | Pfizer | Process for preparing dihydropyridines |
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
-
1985
- 1985-05-29 DE DE8585303765T patent/DE3567460D1/de not_active Expired
- 1985-05-29 EP EP85303765A patent/EP0164247B1/en not_active Expired
- 1985-05-31 JP JP60118702A patent/JPH0641464B2/ja not_active Expired - Lifetime
- 1985-06-03 FI FI852222A patent/FI852222A7/fi not_active Application Discontinuation
- 1985-06-05 PT PT80597A patent/PT80597B/pt not_active IP Right Cessation
- 1985-06-05 US US06/741,339 patent/US4618609A/en not_active Expired - Lifetime
- 1985-06-05 IL IL75411A patent/IL75411A0/xx unknown
- 1985-06-05 PL PL25382185A patent/PL253821A1/xx unknown
- 1985-06-06 HU HU852246A patent/HUT41404A/hu unknown
- 1985-06-06 AU AU43349/85A patent/AU556496B2/en not_active Ceased
- 1985-06-06 DK DK253785A patent/DK170402B1/da not_active IP Right Cessation
- 1985-06-06 IE IE1417/85A patent/IE57816B1/en unknown
- 1985-06-06 GR GR851383A patent/GR851383B/el unknown
- 1985-06-07 ES ES543999A patent/ES8700857A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GR851383B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-11-25 |
| AU556496B2 (en) | 1986-11-06 |
| DK253785A (da) | 1985-12-08 |
| IE57816B1 (en) | 1993-04-21 |
| FI852222L (fi) | 1985-12-08 |
| DK253785D0 (da) | 1985-06-06 |
| DK170402B1 (da) | 1995-08-21 |
| EP0164247B1 (en) | 1989-01-11 |
| FI852222A7 (fi) | 1985-12-08 |
| PT80597A (en) | 1985-07-01 |
| ES8700857A1 (es) | 1986-11-16 |
| PL253821A1 (en) | 1986-07-01 |
| HUT41404A (en) | 1987-04-28 |
| FI852222A0 (fi) | 1985-06-03 |
| PT80597B (en) | 1987-04-23 |
| EP0164247A1 (en) | 1985-12-11 |
| AU4334985A (en) | 1985-12-12 |
| IL75411A0 (en) | 1985-10-31 |
| ES543999A0 (es) | 1986-11-16 |
| DE3567460D1 (en) | 1989-02-16 |
| JPS611685A (ja) | 1986-01-07 |
| US4618609A (en) | 1986-10-21 |
| IE851417L (en) | 1985-12-07 |
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