JPH0625131A - 抗ヘルペスペプチド誘導体 - Google Patents

抗ヘルペスペプチド誘導体

Info

Publication number
JPH0625131A
JPH0625131A JP5051004A JP5100493A JPH0625131A JP H0625131 A JPH0625131 A JP H0625131A JP 5051004 A JP5051004 A JP 5051004A JP 5100493 A JP5100493 A JP 5100493A JP H0625131 A JPH0625131 A JP H0625131A
Authority
JP
Japan
Prior art keywords
cme
tbg
asp
chnhc
nhch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5051004A
Other languages
English (en)
Japanese (ja)
Inventor
Pierre L Beaulieu
ルイ ボーリュー ピエール
Robert Deziel
デジール ロバート
Neil Moss
モス ニール
Raymond Plante
プラント レイモンド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Mega Boehringer Ingelheim Research Inc
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Publication of JPH0625131A publication Critical patent/JPH0625131A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5051004A 1992-03-12 1993-03-11 抗ヘルペスペプチド誘導体 Pending JPH0625131A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84991892A 1992-03-12 1992-03-12
US07/849918 1992-03-12

Publications (1)

Publication Number Publication Date
JPH0625131A true JPH0625131A (ja) 1994-02-01

Family

ID=25306833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5051004A Pending JPH0625131A (ja) 1992-03-12 1993-03-11 抗ヘルペスペプチド誘導体

Country Status (24)

Country Link
EP (1) EP0560267B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0625131A (cg-RX-API-DMAC7.html)
KR (1) KR950700322A (cg-RX-API-DMAC7.html)
AT (1) ATE169931T1 (cg-RX-API-DMAC7.html)
BR (1) BR9306074A (cg-RX-API-DMAC7.html)
CA (1) CA2131186C (cg-RX-API-DMAC7.html)
CZ (1) CZ220994A3 (cg-RX-API-DMAC7.html)
DE (1) DE69320390T2 (cg-RX-API-DMAC7.html)
EE (1) EE9400312A (cg-RX-API-DMAC7.html)
FI (1) FI944187A7 (cg-RX-API-DMAC7.html)
HU (2) HUT68675A (cg-RX-API-DMAC7.html)
IL (1) IL105001A0 (cg-RX-API-DMAC7.html)
LT (1) LT3270B (cg-RX-API-DMAC7.html)
LV (1) LV10461B (cg-RX-API-DMAC7.html)
MX (1) MX9301343A (cg-RX-API-DMAC7.html)
NO (1) NO943345L (cg-RX-API-DMAC7.html)
NZ (1) NZ251266A (cg-RX-API-DMAC7.html)
PH (1) PH30453A (cg-RX-API-DMAC7.html)
RU (1) RU94040865A (cg-RX-API-DMAC7.html)
SG (1) SG42995A1 (cg-RX-API-DMAC7.html)
SK (1) SK107794A3 (cg-RX-API-DMAC7.html)
TW (1) TW278080B (cg-RX-API-DMAC7.html)
WO (1) WO1993018056A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA931745B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2139169C (en) * 1994-12-28 2001-05-01 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes peptidomimetic compounds
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2095408A1 (en) * 1993-05-03 1994-11-04 James Gus Chafouleas Method of combating acyclovir-resistant herpes simplex viral infections
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
TWI867053B (zh) 2019-09-26 2024-12-21 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US481432A (en) 1892-08-23 soler
US4795740A (en) 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4845195A (en) 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4837304A (en) 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
CA1340684C (en) 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE69019786T2 (de) * 1989-07-07 1995-11-16 Bio Mega Boehringer Ingelheim Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
ATE118785T1 (de) 1989-07-07 1995-03-15 Bio Mega Boehringer Ingelheim Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.
US5110799A (en) 1989-07-28 1992-05-05 Merck & Co., Inc. Antiherpetic agents
CA2018801C (en) 1990-06-12 2000-08-22 Pierre Louis Beaulieu Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections

Also Published As

Publication number Publication date
EP0560267A1 (en) 1993-09-15
KR950700322A (ko) 1995-01-16
DE69320390D1 (de) 1998-09-24
FI944187L (fi) 1994-09-12
SK107794A3 (en) 1995-03-08
LV10461B (en) 1996-02-20
BR9306074A (pt) 1997-11-18
HUT68675A (en) 1995-07-28
AU3880793A (en) 1993-10-05
TW278080B (cg-RX-API-DMAC7.html) 1996-06-11
EE9400312A (et) 1996-04-15
EP0560267B1 (en) 1998-08-19
NZ251266A (en) 1996-08-27
ZA931745B (en) 1993-09-24
CA2131186C (en) 2000-12-12
AU671825B2 (en) 1996-09-12
DE69320390T2 (de) 1999-02-11
SG42995A1 (en) 1997-10-17
LV10461A (lv) 1995-02-20
CZ220994A3 (en) 1995-09-13
WO1993018056A1 (en) 1993-09-16
HU9402593D0 (en) 1994-11-28
ATE169931T1 (de) 1998-09-15
RU94040865A (ru) 1996-08-10
NO943345D0 (no) 1994-09-09
LT3270B (en) 1995-05-25
FI944187A0 (fi) 1994-09-12
CA2131186A1 (en) 1993-09-16
PH30453A (en) 1997-05-28
LTIP408A (en) 1994-09-25
MX9301343A (es) 1994-01-31
IL105001A0 (en) 1993-07-08
FI944187A7 (fi) 1994-09-12
NO943345L (no) 1994-09-09
HU211926A9 (en) 1996-01-29

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