FI944187A7 - Isosteeriset antiherpespeptidijohdannaiset - Google Patents
Isosteeriset antiherpespeptidijohdannaiset Download PDFInfo
- Publication number
- FI944187A7 FI944187A7 FI944187A FI944187A FI944187A7 FI 944187 A7 FI944187 A7 FI 944187A7 FI 944187 A FI944187 A FI 944187A FI 944187 A FI944187 A FI 944187A FI 944187 A7 FI944187 A7 FI 944187A7
- Authority
- FI
- Finland
- Prior art keywords
- isosteric
- peptide derivatives
- antiherpes
- antiherpes peptide
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84991892A | 1992-03-12 | 1992-03-12 | |
| PCT/CA1993/000095 WO1993018056A1 (en) | 1992-03-12 | 1993-03-12 | Isosteric antiherpes peptide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI944187L FI944187L (fi) | 1994-09-12 |
| FI944187A0 FI944187A0 (fi) | 1994-09-12 |
| FI944187A7 true FI944187A7 (fi) | 1994-09-12 |
Family
ID=25306833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944187A FI944187A7 (fi) | 1992-03-12 | 1993-03-12 | Isosteeriset antiherpespeptidijohdannaiset |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0560267B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH0625131A (cg-RX-API-DMAC7.html) |
| KR (1) | KR950700322A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE169931T1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9306074A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2131186C (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ220994A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69320390T2 (cg-RX-API-DMAC7.html) |
| EE (1) | EE9400312A (cg-RX-API-DMAC7.html) |
| FI (1) | FI944187A7 (cg-RX-API-DMAC7.html) |
| HU (2) | HUT68675A (cg-RX-API-DMAC7.html) |
| IL (1) | IL105001A0 (cg-RX-API-DMAC7.html) |
| LT (1) | LT3270B (cg-RX-API-DMAC7.html) |
| LV (1) | LV10461B (cg-RX-API-DMAC7.html) |
| MX (1) | MX9301343A (cg-RX-API-DMAC7.html) |
| NO (1) | NO943345L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ251266A (cg-RX-API-DMAC7.html) |
| PH (1) | PH30453A (cg-RX-API-DMAC7.html) |
| RU (1) | RU94040865A (cg-RX-API-DMAC7.html) |
| SG (1) | SG42995A1 (cg-RX-API-DMAC7.html) |
| SK (1) | SK107794A3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW278080B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1993018056A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA931745B (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2139169C (en) * | 1994-12-28 | 2001-05-01 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Antiherpes peptidomimetic compounds |
| US5846941A (en) * | 1992-03-12 | 1998-12-08 | Boehringer Ingelheim (Canada) Ltd. | Isosteric antiherpes peptide derivatives II |
| CA2095408A1 (en) * | 1993-05-03 | 1994-11-04 | James Gus Chafouleas | Method of combating acyclovir-resistant herpes simplex viral infections |
| CA2152541C (en) * | 1995-06-23 | 1998-12-15 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Herpes ribonucleotide reductase inhibitors |
| US5948935A (en) * | 1997-01-23 | 1999-09-07 | Boehringer Ingelheim (Canada) Ltd. | Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid |
| DE69943314D1 (de) * | 1998-02-12 | 2011-05-12 | Kapil N Bhalla | Sphingolipid-derivate und verfahren zu deren verwendung |
| AU2019339777B2 (en) | 2018-09-12 | 2022-09-01 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| TWI867053B (zh) | 2019-09-26 | 2024-12-21 | 瑞士商諾華公司 | 抗病毒吡唑并吡啶酮化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US481432A (en) | 1892-08-23 | soler | ||
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4845195A (en) | 1987-05-22 | 1989-07-04 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US4837304A (en) | 1987-05-22 | 1989-06-06 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| CA1340684C (en) | 1989-07-07 | 1999-07-27 | Pierre Louis Beaulieu | Antiherpes pentapeptides |
| CA1340682C (en) * | 1989-07-07 | 1999-07-27 | Pierre Lavallee | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| DE69019786T2 (de) * | 1989-07-07 | 1995-11-16 | Bio Mega Boehringer Ingelheim | Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure. |
| ATE118785T1 (de) | 1989-07-07 | 1995-03-15 | Bio Mega Boehringer Ingelheim | Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten. |
| US5110799A (en) | 1989-07-28 | 1992-05-05 | Merck & Co., Inc. | Antiherpetic agents |
| CA2018801C (en) | 1990-06-12 | 2000-08-22 | Pierre Louis Beaulieu | Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus |
| CA2033447C (en) * | 1990-12-31 | 1999-08-31 | Robert Deziel | Synergistic combination for treating herpes infections |
-
1993
- 1993-03-09 SG SG1996001914A patent/SG42995A1/en unknown
- 1993-03-09 AT AT93103711T patent/ATE169931T1/de not_active IP Right Cessation
- 1993-03-09 DE DE69320390T patent/DE69320390T2/de not_active Expired - Fee Related
- 1993-03-09 EP EP93103711A patent/EP0560267B1/en not_active Expired - Lifetime
- 1993-03-10 IL IL105001A patent/IL105001A0/xx unknown
- 1993-03-11 JP JP5051004A patent/JPH0625131A/ja active Pending
- 1993-03-11 PH PH45860A patent/PH30453A/en unknown
- 1993-03-11 ZA ZA931745A patent/ZA931745B/xx unknown
- 1993-03-11 MX MX9301343A patent/MX9301343A/es not_active IP Right Cessation
- 1993-03-12 FI FI944187A patent/FI944187A7/fi not_active Application Discontinuation
- 1993-03-12 BR BR9306074A patent/BR9306074A/pt not_active Application Discontinuation
- 1993-03-12 RU RU94040865/04A patent/RU94040865A/ru unknown
- 1993-03-12 CA CA002131186A patent/CA2131186C/en not_active Expired - Fee Related
- 1993-03-12 CZ CZ942209A patent/CZ220994A3/cs unknown
- 1993-03-12 LV LVP-93-186A patent/LV10461B/en unknown
- 1993-03-12 LT LTIP408A patent/LT3270B/lt not_active IP Right Cessation
- 1993-03-12 SK SK1077-94A patent/SK107794A3/sk unknown
- 1993-03-12 NZ NZ251266A patent/NZ251266A/en unknown
- 1993-03-12 HU HU9402593A patent/HUT68675A/hu unknown
- 1993-03-12 WO PCT/CA1993/000095 patent/WO1993018056A1/en not_active Ceased
- 1993-03-23 TW TW082102135A patent/TW278080B/zh active
-
1994
- 1994-09-09 NO NO943345A patent/NO943345L/no unknown
- 1994-09-10 KR KR1019940703166A patent/KR950700322A/ko not_active Withdrawn
- 1994-11-23 EE EE9400312A patent/EE9400312A/xx unknown
-
1995
- 1995-06-23 HU HU95P/P00431P patent/HU211926A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0560267A1 (en) | 1993-09-15 |
| KR950700322A (ko) | 1995-01-16 |
| DE69320390D1 (de) | 1998-09-24 |
| FI944187L (fi) | 1994-09-12 |
| SK107794A3 (en) | 1995-03-08 |
| LV10461B (en) | 1996-02-20 |
| BR9306074A (pt) | 1997-11-18 |
| HUT68675A (en) | 1995-07-28 |
| AU3880793A (en) | 1993-10-05 |
| TW278080B (cg-RX-API-DMAC7.html) | 1996-06-11 |
| EE9400312A (et) | 1996-04-15 |
| EP0560267B1 (en) | 1998-08-19 |
| JPH0625131A (ja) | 1994-02-01 |
| NZ251266A (en) | 1996-08-27 |
| ZA931745B (en) | 1993-09-24 |
| CA2131186C (en) | 2000-12-12 |
| AU671825B2 (en) | 1996-09-12 |
| DE69320390T2 (de) | 1999-02-11 |
| SG42995A1 (en) | 1997-10-17 |
| LV10461A (lv) | 1995-02-20 |
| CZ220994A3 (en) | 1995-09-13 |
| WO1993018056A1 (en) | 1993-09-16 |
| HU9402593D0 (en) | 1994-11-28 |
| ATE169931T1 (de) | 1998-09-15 |
| RU94040865A (ru) | 1996-08-10 |
| NO943345D0 (no) | 1994-09-09 |
| LT3270B (en) | 1995-05-25 |
| FI944187A0 (fi) | 1994-09-12 |
| CA2131186A1 (en) | 1993-09-16 |
| PH30453A (en) | 1997-05-28 |
| LTIP408A (en) | 1994-09-25 |
| MX9301343A (es) | 1994-01-31 |
| IL105001A0 (en) | 1993-07-08 |
| NO943345L (no) | 1994-09-09 |
| HU211926A9 (en) | 1996-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: BOEHRINGER INGELHEIM (CANADA) LTD. |
|
| FD | Application lapsed |