DE69019786T2 - Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure. - Google Patents

Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.

Info

Publication number
DE69019786T2
DE69019786T2 DE69019786T DE69019786T DE69019786T2 DE 69019786 T2 DE69019786 T2 DE 69019786T2 DE 69019786 T DE69019786 T DE 69019786T DE 69019786 T DE69019786 T DE 69019786T DE 69019786 T2 DE69019786 T2 DE 69019786T2
Authority
DE
Germany
Prior art keywords
antiherpes
side chain
aspartic acid
hydrogen
chain made
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69019786T
Other languages
English (en)
Other versions
DE69019786D1 (de
Inventor
Julian Adams
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA000605061A external-priority patent/CA1340681C/en
Priority claimed from CA 2019006 external-priority patent/CA2019006C/en
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Application granted granted Critical
Publication of DE69019786D1 publication Critical patent/DE69019786D1/de
Publication of DE69019786T2 publication Critical patent/DE69019786T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
DE69019786T 1989-07-07 1990-07-03 Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure. Expired - Fee Related DE69019786T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA000605061A CA1340681C (en) 1989-07-07 1989-07-07 Antiherpes tetrapeptides having a substituted aspartic acid side chain
CA 2019006 CA2019006C (en) 1990-06-14 1990-06-14 Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Publications (2)

Publication Number Publication Date
DE69019786D1 DE69019786D1 (de) 1995-07-06
DE69019786T2 true DE69019786T2 (de) 1995-11-16

Family

ID=25672868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69019786T Expired - Fee Related DE69019786T2 (de) 1989-07-07 1990-07-03 Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.

Country Status (6)

Country Link
EP (1) EP0411333B1 (de)
JP (1) JP2879799B2 (de)
AT (1) ATE123294T1 (de)
AU (1) AU643403B2 (de)
DE (1) DE69019786T2 (de)
IL (1) IL94982A (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
SG42995A1 (en) 1992-03-12 1997-10-17 Bio Mega Boehringer Ingelheim Isosteric antiherpes peptide derivatives
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
CA1327869C (en) * 1989-02-17 1994-03-15 Yvan Guindon Ribonucleotide reductase inhibitors
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain

Also Published As

Publication number Publication date
EP0411333B1 (de) 1995-05-31
IL94982A (en) 1995-11-27
ATE123294T1 (de) 1995-06-15
JP2879799B2 (ja) 1999-04-05
DE69019786D1 (de) 1995-07-06
IL94982A0 (en) 1991-06-10
JPH03215495A (ja) 1991-09-20
AU5877690A (en) 1991-01-10
AU643403B2 (en) 1993-11-11
EP0411333A1 (de) 1991-02-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD., LAVAL, QUEBEC,

8339 Ceased/non-payment of the annual fee