ATE120202T1 - Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus. - Google Patents

Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus.

Info

Publication number
ATE120202T1
ATE120202T1 AT91109243T AT91109243T ATE120202T1 AT E120202 T1 ATE120202 T1 AT E120202T1 AT 91109243 T AT91109243 T AT 91109243T AT 91109243 T AT91109243 T AT 91109243T AT E120202 T1 ATE120202 T1 AT E120202T1
Authority
AT
Austria
Prior art keywords
alkyl
cycloalkyl
hydrogen
peptide derivatives
dioxo
Prior art date
Application number
AT91109243T
Other languages
English (en)
Inventor
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Application granted granted Critical
Publication of ATE120202T1 publication Critical patent/ATE120202T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT91109243T 1990-06-12 1991-06-06 Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus. ATE120202T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002018801A CA2018801C (en) 1990-06-12 1990-06-12 Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
US08/219,600 US5484771A (en) 1990-06-12 1994-03-29 Antiherpes peptide derivatives having a 1,4-dioxo-C, N-terminus

Publications (1)

Publication Number Publication Date
ATE120202T1 true ATE120202T1 (de) 1995-04-15

Family

ID=25674164

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91109243T ATE120202T1 (de) 1990-06-12 1991-06-06 Antiherpes-peptidderivate mit einem 1,4-dioxo-c4- n-terminus.

Country Status (8)

Country Link
US (1) US5484771A (de)
EP (1) EP0461546B1 (de)
JP (1) JP3043833B2 (de)
AT (1) ATE120202T1 (de)
CA (1) CA2018801C (de)
DE (1) DE69108299T2 (de)
IL (1) IL98443A (de)
NZ (1) NZ238455A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69320390T2 (de) 1992-03-12 1999-02-11 Boehringer Ingelheim (Canada) Ltd., Laval, Quebec Isosterische Peptidderivate gegen Herpes
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
JP4956802B2 (ja) * 2003-09-10 2012-06-20 独立行政法人理化学研究所 非天然型塩基を有するヌクレオシド又はヌクレオチド及びその利用
SG158148A1 (en) 2004-12-22 2010-01-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
PL1954710T3 (pl) 2005-11-08 2011-09-30 Ambrx Inc Przyspieszacze do modyfikacji aminokwasów niewystępujących w przyrodzie i polipeptydów zbudowanych z aminokwasów nie występujących w przyrodzie
CA2882445A1 (en) * 2005-12-14 2007-06-21 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
JP5974084B2 (ja) 2011-05-17 2016-08-23 プリンシピア バイオファーマ インコーポレイテッド チロシンキナーゼ阻害剤
NZ630925A (en) 2012-09-10 2016-10-28 Principia Biopharma Inc Pyrazolopyrimidine compounds as kinase inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
ES2841248T3 (es) 2014-02-21 2021-07-07 Principia Biopharma Inc Sales y forma sólida de un inhibidor de BTK
US10485797B2 (en) 2014-12-18 2019-11-26 Principia Biopharma Inc. Treatment of pemphigus
US20180305350A1 (en) 2015-06-24 2018-10-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN115054586B (zh) 2016-06-29 2024-08-02 普林斯匹亚生物制药公司 改性的释放制剂
CN112996789A (zh) 2018-09-12 2021-06-18 诺华股份有限公司 抗病毒吡啶并吡嗪二酮化合物
KR20220070005A (ko) 2019-09-26 2022-05-27 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
JPH04500963A (ja) * 1988-09-26 1992-02-20 ジ・アップジョン・カンパニー マレアミド置換基を含有するレニン抑制ペプチド類
DE3839559A1 (de) * 1988-11-24 1990-05-31 Hoechst Ag Renin-hemmende aminodiol-derivate

Also Published As

Publication number Publication date
CA2018801A1 (en) 1991-12-12
JP3043833B2 (ja) 2000-05-22
JPH04243892A (ja) 1992-08-31
EP0461546B1 (de) 1995-03-22
DE69108299T2 (de) 1995-08-10
CA2018801C (en) 2000-08-22
NZ238455A (en) 1993-12-23
EP0461546A3 (en) 1993-03-24
EP0461546A2 (de) 1991-12-18
IL98443A (en) 1995-07-31
US5484771A (en) 1996-01-16
DE69108299D1 (de) 1995-04-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties