DE69108299D1 - Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus. - Google Patents

Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.

Info

Publication number
DE69108299D1
DE69108299D1 DE69108299T DE69108299T DE69108299D1 DE 69108299 D1 DE69108299 D1 DE 69108299D1 DE 69108299 T DE69108299 T DE 69108299T DE 69108299 T DE69108299 T DE 69108299T DE 69108299 D1 DE69108299 D1 DE 69108299D1
Authority
DE
Germany
Prior art keywords
alkyl
cycloalkyl
hydrogen
peptide derivatives
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108299T
Other languages
English (en)
Other versions
DE69108299T2 (de
Inventor
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Application granted granted Critical
Publication of DE69108299D1 publication Critical patent/DE69108299D1/de
Publication of DE69108299T2 publication Critical patent/DE69108299T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0819Tripeptides with the first amino acid being acidic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69108299T 1990-06-12 1991-06-06 Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus. Expired - Fee Related DE69108299T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002018801A CA2018801C (en) 1990-06-12 1990-06-12 Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
US08/219,600 US5484771A (en) 1990-06-12 1994-03-29 Antiherpes peptide derivatives having a 1,4-dioxo-C, N-terminus

Publications (2)

Publication Number Publication Date
DE69108299D1 true DE69108299D1 (de) 1995-04-27
DE69108299T2 DE69108299T2 (de) 1995-08-10

Family

ID=25674164

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108299T Expired - Fee Related DE69108299T2 (de) 1990-06-12 1991-06-06 Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.

Country Status (8)

Country Link
US (1) US5484771A (de)
EP (1) EP0461546B1 (de)
JP (1) JP3043833B2 (de)
AT (1) ATE120202T1 (de)
CA (1) CA2018801C (de)
DE (1) DE69108299T2 (de)
IL (1) IL98443A (de)
NZ (1) NZ238455A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG42995A1 (en) 1992-03-12 1997-10-17 Bio Mega Boehringer Ingelheim Isosteric antiherpes peptide derivatives
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
US20110087015A1 (en) * 2003-09-10 2011-04-14 Riken Nucleoside and nucleotide having an unnatural base and use thereof
US7385028B2 (en) * 2004-12-22 2008-06-10 Ambrx, Inc Derivatization of non-natural amino acids and polypeptides
CN104710503B (zh) * 2005-11-08 2023-04-25 Ambrx 公司 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂
SG170116A1 (en) 2005-12-14 2011-04-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
SI2710005T1 (sl) 2011-05-17 2017-03-31 Principia Biopharma Inc. Zaviralci tirozinske kinaze
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
MX361815B (es) 2012-09-10 2018-12-17 Principia Biopharma Inc Compuestos pirazolopirimidinicos como inhibidores de cinasas.
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
KR20220027271A (ko) 2014-02-21 2022-03-07 프린시피아 바이오파마, 인코퍼레이티드 Btk 억제제의 염 및 고체 형태
WO2016100914A1 (en) 2014-12-18 2016-06-23 Gourlay Steven Treatment of pemphigus
TW201718572A (zh) 2015-06-24 2017-06-01 普林斯匹亞生物製藥公司 酪胺酸激酶抑制劑
IL293621B2 (en) 2016-06-29 2023-09-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
TW202126649A (zh) 2019-09-26 2021-07-16 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
JPH04500963A (ja) * 1988-09-26 1992-02-20 ジ・アップジョン・カンパニー マレアミド置換基を含有するレニン抑制ペプチド類
DE3839559A1 (de) * 1988-11-24 1990-05-31 Hoechst Ag Renin-hemmende aminodiol-derivate

Also Published As

Publication number Publication date
ATE120202T1 (de) 1995-04-15
US5484771A (en) 1996-01-16
DE69108299T2 (de) 1995-08-10
CA2018801C (en) 2000-08-22
NZ238455A (en) 1993-12-23
IL98443A (en) 1995-07-31
JP3043833B2 (ja) 2000-05-22
EP0461546B1 (de) 1995-03-22
EP0461546A2 (de) 1991-12-18
EP0461546A3 (en) 1993-03-24
JPH04243892A (ja) 1992-08-31
CA2018801A1 (en) 1991-12-12

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: LAUDIEN, D., DIPL.-CHEM. DR.PHIL.NAT., PAT.-ASS., 6500 MAINZ

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD., LAVAL, QUEBEC,

8339 Ceased/non-payment of the annual fee