DE69108299D1 - Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus. - Google Patents

Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.

Info

Publication number
DE69108299D1
DE69108299D1 DE69108299T DE69108299T DE69108299D1 DE 69108299 D1 DE69108299 D1 DE 69108299D1 DE 69108299 T DE69108299 T DE 69108299T DE 69108299 T DE69108299 T DE 69108299T DE 69108299 D1 DE69108299 D1 DE 69108299D1
Authority
DE
Germany
Prior art keywords
alkyl
cycloalkyl
hydrogen
peptide derivatives
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108299T
Other languages
English (en)
Other versions
DE69108299T2 (de
Inventor
Pierre Louis Beaulieu
Robert Deziel
Neil Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Application granted granted Critical
Publication of DE69108299D1 publication Critical patent/DE69108299D1/de
Publication of DE69108299T2 publication Critical patent/DE69108299T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69108299T 1990-06-12 1991-06-06 Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus. Expired - Fee Related DE69108299T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002018801A CA2018801C (en) 1990-06-12 1990-06-12 Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
US08/219,600 US5484771A (en) 1990-06-12 1994-03-29 Antiherpes peptide derivatives having a 1,4-dioxo-C, N-terminus

Publications (2)

Publication Number Publication Date
DE69108299D1 true DE69108299D1 (de) 1995-04-27
DE69108299T2 DE69108299T2 (de) 1995-08-10

Family

ID=25674164

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108299T Expired - Fee Related DE69108299T2 (de) 1990-06-12 1991-06-06 Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.

Country Status (8)

Country Link
US (1) US5484771A (de)
EP (1) EP0461546B1 (de)
JP (1) JP3043833B2 (de)
AT (1) ATE120202T1 (de)
CA (1) CA2018801C (de)
DE (1) DE69108299T2 (de)
IL (1) IL98443A (de)
NZ (1) NZ238455A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG42995A1 (en) 1992-03-12 1997-10-17 Bio Mega Boehringer Ingelheim Isosteric antiherpes peptide derivatives
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
JP4956802B2 (ja) * 2003-09-10 2012-06-20 独立行政法人理化学研究所 非天然型塩基を有するヌクレオシド又はヌクレオチド及びその利用
MX2007007590A (es) * 2004-12-22 2007-12-10 Ambrx Inc Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
SI1954710T1 (sl) * 2005-11-08 2011-08-31 Ambrx Inc Pospeĺ evala za modifikacijo nenaravnih aminokislin in nenaravnih peptidov aminokislin
AU2006326404B2 (en) 2005-12-14 2011-11-03 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
EP2710005B1 (de) 2011-05-17 2016-10-05 Principia Biopharma Inc. Tyrosinkinase-hemmer
PT2892900T (pt) 2012-09-10 2017-11-06 Principia Biopharma Inc Compostos de pirazolopirimidina como inibidores de cinase
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
CN107257686B (zh) 2014-12-18 2021-01-29 普林斯匹亚生物制药公司 天疱疮的治疗
TW201718572A (zh) 2015-06-24 2017-06-01 普林斯匹亞生物製藥公司 酪胺酸激酶抑制劑
SG11201811255WA (en) 2016-06-29 2019-01-30 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
WO1990003389A1 (en) * 1988-09-26 1990-04-05 The Upjohn Company Renin inhibitory peptides containing maleamide substituents
DE3839559A1 (de) * 1988-11-24 1990-05-31 Hoechst Ag Renin-hemmende aminodiol-derivate

Also Published As

Publication number Publication date
EP0461546A2 (de) 1991-12-18
NZ238455A (en) 1993-12-23
DE69108299T2 (de) 1995-08-10
CA2018801C (en) 2000-08-22
US5484771A (en) 1996-01-16
JPH04243892A (ja) 1992-08-31
EP0461546A3 (en) 1993-03-24
EP0461546B1 (de) 1995-03-22
IL98443A (en) 1995-07-31
ATE120202T1 (de) 1995-04-15
JP3043833B2 (ja) 2000-05-22
CA2018801A1 (en) 1991-12-12

Similar Documents

Publication Publication Date Title
DE69108299T2 (de) Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.
MD1743B2 (ro) Derivaţi ai indolului, procedeu de obţinere a lor, compoziţie fungicidă şi procedeu de combatere a fungilor
KR950700322A (ko) 이소스테릭 항헤르페스 펩타이드 유도체(Isosteric antiherpes peptide derivatives)
TW221429B (de)
AU643448B2 (en) Antiviral peptides having a 2-Oxoalkyl amino acid side chain
AU623500B2 (en) Carboxylimino benzothiazole derivatives
LV11037A (lv) Herpes virusa ribonukleotidu reduktazes inhibitori
DE69019786T2 (de) Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
NO304314B1 (no) Cykloheksanderivater og anvendelse av forbindelsene for fremstilling av legemidler
AU640723B2 (en) 2-formylbenzylphosphonic acid derivatives, their preparation and their use for the treatment of diseases caused by viruses
ES8503646A1 (es) Procedimiento para la obtencion de derivados de bencilurea.

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: LAUDIEN, D., DIPL.-CHEM. DR.PHIL.NAT., PAT.-ASS., 6500 MAINZ

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD., LAVAL, QUEBEC,

8339 Ceased/non-payment of the annual fee