DE69017113T2 - Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten. - Google Patents

Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten.

Info

Publication number
DE69017113T2
DE69017113T2 DE69017113T DE69017113T DE69017113T2 DE 69017113 T2 DE69017113 T2 DE 69017113T2 DE 69017113 T DE69017113 T DE 69017113T DE 69017113 T DE69017113 T DE 69017113T DE 69017113 T2 DE69017113 T2 DE 69017113T2
Authority
DE
Germany
Prior art keywords
contain
side chain
aspartic acid
effective against
acid side
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69017113T
Other languages
English (en)
Other versions
DE69017113D1 (de
Inventor
Julian Adams
Pierre Louis Beaulieu
Robert Deziel
John Dimaio
Louis Grenier
Pierre Lavallee
Neil Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA000605091A external-priority patent/CA1340683C/en
Priority claimed from CA002019005A external-priority patent/CA2019005C/en
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Publication of DE69017113D1 publication Critical patent/DE69017113D1/de
Application granted granted Critical
Publication of DE69017113T2 publication Critical patent/DE69017113T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
DE69017113T 1989-07-07 1990-07-03 Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten. Expired - Fee Related DE69017113T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA000605091A CA1340683C (en) 1989-07-07 1989-07-07 Antiherpes pentapeptides having a substituted aspartic acid side chain
CA002019005A CA2019005C (en) 1990-06-14 1990-06-14 Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Publications (2)

Publication Number Publication Date
DE69017113D1 DE69017113D1 (de) 1995-03-30
DE69017113T2 true DE69017113T2 (de) 1995-08-03

Family

ID=25672870

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017113T Expired - Fee Related DE69017113T2 (de) 1989-07-07 1990-07-03 Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten.

Country Status (6)

Country Link
EP (1) EP0411334B1 (de)
JP (1) JP2877909B2 (de)
AT (1) ATE118785T1 (de)
DE (1) DE69017113T2 (de)
IL (1) IL94980A (de)
NZ (1) NZ234376A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE169931T1 (de) 1992-03-12 1998-09-15 Boehringer Ingelheim Ca Ltd Isosterische peptidderivate gegen herpes
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
PT618226E (pt) * 1993-03-03 2001-03-30 Boehringer Ingelheim Ca Ltd Inibidores de ribonucleotido redutase de virus do herpes
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
JP5828217B2 (ja) 2011-04-15 2015-12-02 三菱マテリアル株式会社 ドリル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase

Also Published As

Publication number Publication date
EP0411334B1 (de) 1995-02-22
JPH03215497A (ja) 1991-09-20
IL94980A (en) 1995-03-15
IL94980A0 (en) 1991-06-10
ATE118785T1 (de) 1995-03-15
DE69017113D1 (de) 1995-03-30
JP2877909B2 (ja) 1999-04-05
EP0411334A1 (de) 1991-02-06
NZ234376A (en) 1997-05-26

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: LAUDIEN, D., DIPL.-CHEM. DR.PHIL.NAT., PAT.-ASS., 6500 MAINZ

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD., LAVAL, QUEBEC,

8339 Ceased/non-payment of the annual fee