CA2019006A1 - Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain - Google Patents
Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chainInfo
- Publication number
- CA2019006A1 CA2019006A1 CA 2019006 CA2019006A CA2019006A1 CA 2019006 A1 CA2019006 A1 CA 2019006A1 CA 2019006 CA2019006 CA 2019006 CA 2019006 A CA2019006 A CA 2019006A CA 2019006 A1 CA2019006 A1 CA 2019006A1
- Authority
- CA
- Canada
- Prior art keywords
- antiherpes
- side chain
- aspartic acid
- acid side
- cycloalkyl substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Disclosed herein are tetrapeptide derivatives of the formula X-NH-CHR1-C(W1)-NR2-CH[CH2C(O)-Y]-C(W2)-NH-CH[CR3(R5)-COON]-C(W3)-NH-CHR5-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 and R5 are selected from amino acid or derived amino acid residues, R2 is hydrogen, alkyl or phenylalkyl, R3 and R4 are joined to form a cycloalkyl, W1, W2 and W3 are oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COON or CH2OH. The derivatives are useful for treating herpes infections.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2019006 CA2019006C (en) | 1990-06-14 | 1990-06-14 | Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
EP90112645A EP0411333B1 (en) | 1989-07-07 | 1990-07-03 | Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain |
AT90112645T ATE123294T1 (en) | 1989-07-07 | 1990-07-03 | ANTIHERPES TETRAPEPTIDE DERIVATIVES WITH A SUBSTITUTED ASPARAGIC ACID SIDE CHAIN. |
DE69019786T DE69019786T2 (en) | 1989-07-07 | 1990-07-03 | Antiherpes tetrapeptide derivatives with a substituted side chain made of aspartic acid. |
IL9498290A IL94982A (en) | 1989-07-07 | 1990-07-05 | Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain their preparation and pharmaceutical compositions containing them |
NZ23437390A NZ234373A (en) | 1989-07-07 | 1990-07-05 | Acylated n-terminal tetrapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections |
AU58776/90A AU643403B2 (en) | 1989-07-07 | 1990-07-06 | Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain |
JP2179375A JP2879799B2 (en) | 1989-07-07 | 1990-07-06 | Anti-herpes tetrapeptide derivatives having substituted aspartic acid side chains |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2019006 CA2019006C (en) | 1990-06-14 | 1990-06-14 | Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2019006A1 true CA2019006A1 (en) | 1991-12-14 |
CA2019006C CA2019006C (en) | 2000-06-13 |
Family
ID=4145233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2019006 Expired - Fee Related CA2019006C (en) | 1989-07-07 | 1990-06-14 | Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2019006C (en) |
-
1990
- 1990-06-14 CA CA 2019006 patent/CA2019006C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2019006C (en) | 2000-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |