CA2019005A1 - Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain - Google Patents

Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Info

Publication number
CA2019005A1
CA2019005A1 CA2019005A CA2019005A CA2019005A1 CA 2019005 A1 CA2019005 A1 CA 2019005A1 CA 2019005 A CA2019005 A CA 2019005A CA 2019005 A CA2019005 A CA 2019005A CA 2019005 A1 CA2019005 A1 CA 2019005A1
Authority
CA
Canada
Prior art keywords
antiherpes
side chain
aspartic acid
acid side
cycloalkyl substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2019005A
Other languages
French (fr)
Other versions
CA2019005C (en
Inventor
Robert Deziel
Neil Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Inc filed Critical Bio Mega Inc
Priority to CA002019005A priority Critical patent/CA2019005C/en
Priority to DE69017113T priority patent/DE69017113T2/en
Priority to AT90112646T priority patent/ATE118785T1/en
Priority to EP90112646A priority patent/EP0411334B1/en
Priority to IL9498090A priority patent/IL94980A/en
Priority to NZ234376A priority patent/NZ234376A/en
Priority to JP2179373A priority patent/JP2877909B2/en
Publication of CA2019005A1 publication Critical patent/CA2019005A1/en
Application granted granted Critical
Publication of CA2019005C publication Critical patent/CA2019005C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Disclosed herein are pentapeptide derivatives of the formula X-NR1-CH(R2)-C(W1)-NH-CR3(R4)-C(W2)-NR5-CH[CH2C(O)-Y]-C(W3)-NH-CR6-[CR7(R8)-COOH]-C(W4)-NH-CR9(R10-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 is hydrogen, alkyl or phenylalkyl, R2, R4 and R10 are selected from amino acid or derived amino acid residues, R3, R5, R6 and R9 are hydrogen or alkyl, R7 and R8 are joined to form a cycloalkyl, W1, W2, W3 and W4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections.
CA002019005A 1989-07-07 1990-06-14 Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain Expired - Fee Related CA2019005C (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002019005A CA2019005C (en) 1990-06-14 1990-06-14 Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
AT90112646T ATE118785T1 (en) 1989-07-07 1990-07-03 PENTAPEPTIDE DERIVATIVES, EFFECTIVE AGAINST HERPES, CONTAINING A REPLACED ASPARAGIC ACID SIDE CHAIN.
EP90112646A EP0411334B1 (en) 1989-07-07 1990-07-03 Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
DE69017113T DE69017113T2 (en) 1989-07-07 1990-07-03 Pentapeptide derivatives, effective against herpes, which contain a replaced aspartic acid side chain.
IL9498090A IL94980A (en) 1989-07-07 1990-07-05 Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain, their preparation and pharmaceutical compositions containing them.
NZ234376A NZ234376A (en) 1989-07-07 1990-07-05 Acylated n-terminal pentapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections
JP2179373A JP2877909B2 (en) 1989-07-07 1990-07-06 Anti-herpes pentapeptide derivatives having substituted aspartic acid side chains

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002019005A CA2019005C (en) 1990-06-14 1990-06-14 Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Publications (2)

Publication Number Publication Date
CA2019005A1 true CA2019005A1 (en) 1991-12-14
CA2019005C CA2019005C (en) 2000-04-18

Family

ID=4145232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002019005A Expired - Fee Related CA2019005C (en) 1989-07-07 1990-06-14 Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain

Country Status (1)

Country Link
CA (1) CA2019005C (en)

Also Published As

Publication number Publication date
CA2019005C (en) 2000-04-18

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