CA2019005A1 - Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain - Google Patents
Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chainInfo
- Publication number
- CA2019005A1 CA2019005A1 CA2019005A CA2019005A CA2019005A1 CA 2019005 A1 CA2019005 A1 CA 2019005A1 CA 2019005 A CA2019005 A CA 2019005A CA 2019005 A CA2019005 A CA 2019005A CA 2019005 A1 CA2019005 A1 CA 2019005A1
- Authority
- CA
- Canada
- Prior art keywords
- antiherpes
- side chain
- aspartic acid
- acid side
- cycloalkyl substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Disclosed herein are pentapeptide derivatives of the formula X-NR1-CH(R2)-C(W1)-NH-CR3(R4)-C(W2)-NR5-CH[CH2C(O)-Y]-C(W3)-NH-CR6-[CR7(R8)-COOH]-C(W4)-NH-CR9(R10-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 is hydrogen, alkyl or phenylalkyl, R2, R4 and R10 are selected from amino acid or derived amino acid residues, R3, R5, R6 and R9 are hydrogen or alkyl, R7 and R8 are joined to form a cycloalkyl, W1, W2, W3 and W4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002019005A CA2019005C (en) | 1990-06-14 | 1990-06-14 | Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
AT90112646T ATE118785T1 (en) | 1989-07-07 | 1990-07-03 | PENTAPEPTIDE DERIVATIVES, EFFECTIVE AGAINST HERPES, CONTAINING A REPLACED ASPARAGIC ACID SIDE CHAIN. |
EP90112646A EP0411334B1 (en) | 1989-07-07 | 1990-07-03 | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain |
DE69017113T DE69017113T2 (en) | 1989-07-07 | 1990-07-03 | Pentapeptide derivatives, effective against herpes, which contain a replaced aspartic acid side chain. |
IL9498090A IL94980A (en) | 1989-07-07 | 1990-07-05 | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain, their preparation and pharmaceutical compositions containing them. |
NZ234376A NZ234376A (en) | 1989-07-07 | 1990-07-05 | Acylated n-terminal pentapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections |
JP2179373A JP2877909B2 (en) | 1989-07-07 | 1990-07-06 | Anti-herpes pentapeptide derivatives having substituted aspartic acid side chains |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002019005A CA2019005C (en) | 1990-06-14 | 1990-06-14 | Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2019005A1 true CA2019005A1 (en) | 1991-12-14 |
CA2019005C CA2019005C (en) | 2000-04-18 |
Family
ID=4145232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002019005A Expired - Fee Related CA2019005C (en) | 1989-07-07 | 1990-06-14 | Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2019005C (en) |
-
1990
- 1990-06-14 CA CA002019005A patent/CA2019005C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2019005C (en) | 2000-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |