ATE131174T1 - Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten. - Google Patents

Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten.

Info

Publication number
ATE131174T1
ATE131174T1 AT90112644T AT90112644T ATE131174T1 AT E131174 T1 ATE131174 T1 AT E131174T1 AT 90112644 T AT90112644 T AT 90112644T AT 90112644 T AT90112644 T AT 90112644T AT E131174 T1 ATE131174 T1 AT E131174T1
Authority
AT
Austria
Prior art keywords
ketoalkylaminosic
side chain
acid side
peptides containing
alkyl
Prior art date
Application number
AT90112644T
Other languages
English (en)
Inventor
Pierre Louis Beaulieu
Robert Deziel
Pierre Lavallee
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Application granted granted Critical
Publication of ATE131174T1 publication Critical patent/ATE131174T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
AT90112644T 1989-07-07 1990-07-03 Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten. ATE131174T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000605062A CA1340682C (en) 1989-07-07 1989-07-07 Antiviral peptides having a 2-oxoalkyl amino acid side chain

Publications (1)

Publication Number Publication Date
ATE131174T1 true ATE131174T1 (de) 1995-12-15

Family

ID=4140313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90112644T ATE131174T1 (de) 1989-07-07 1990-07-03 Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten.

Country Status (8)

Country Link
US (1) US5700780A (de)
EP (1) EP0411332B1 (de)
JP (1) JP2877910B2 (de)
AT (1) ATE131174T1 (de)
AU (1) AU643448B2 (de)
CA (1) CA1340682C (de)
DE (1) DE69023977T2 (de)
IL (1) IL94981A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
DE69019786T2 (de) * 1989-07-07 1995-11-16 Bio Mega Boehringer Ingelheim Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
CA1340681C (en) * 1989-07-07 1999-07-27 Robert Deziel Antiherpes tetrapeptides having a substituted aspartic acid side chain
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
SG42995A1 (en) * 1992-03-12 1997-10-17 Bio Mega Boehringer Ingelheim Isosteric antiherpes peptide derivatives
WO2000017226A1 (en) * 1998-09-23 2000-03-30 The Regents Of The University Of California Synthetic peptides, conjugation reagents and methods
CA2399676C (en) 2000-02-07 2010-04-06 Wisconsin Alumni Research Foundation Pharmacologically active antiviral peptides and methods of their use
US7432045B2 (en) * 2003-12-01 2008-10-07 Wisconsin Alumni Research Foundation Method of inhibiting influenza infection with antiviral peptides

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4837304A (en) * 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
US4845195A (en) * 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4814432A (en) * 1987-05-22 1989-03-21 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
EP0357332A3 (de) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin-Inhibitoren zur Behandlung von AIDS durch Hemmung der HIV-Protease
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
CA1340683C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides having a substituted aspartic acid side chain
CA1340684C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
DE69019786T2 (de) * 1989-07-07 1995-11-16 Bio Mega Boehringer Ingelheim Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.

Also Published As

Publication number Publication date
DE69023977T2 (de) 1996-05-15
EP0411332B1 (de) 1995-12-06
JPH03115296A (ja) 1991-05-16
IL94981A0 (en) 1991-06-10
CA1340682C (en) 1999-07-27
JP2877910B2 (ja) 1999-04-05
US5700780A (en) 1997-12-23
AU5877790A (en) 1991-01-10
AU643448B2 (en) 1993-11-18
IL94981A (en) 1995-03-15
DE69023977D1 (de) 1996-01-18
EP0411332A1 (de) 1991-02-06

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