DE69023977T2 - Antivirale Peptide, die eine 2-Ketoalkylaminosäureseitenkette enthalten. - Google Patents

Antivirale Peptide, die eine 2-Ketoalkylaminosäureseitenkette enthalten.

Info

Publication number
DE69023977T2
DE69023977T2 DE69023977T DE69023977T DE69023977T2 DE 69023977 T2 DE69023977 T2 DE 69023977T2 DE 69023977 T DE69023977 T DE 69023977T DE 69023977 T DE69023977 T DE 69023977T DE 69023977 T2 DE69023977 T2 DE 69023977T2
Authority
DE
Germany
Prior art keywords
ketoalkylamino
side chain
acid side
peptides containing
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69023977T
Other languages
English (en)
Other versions
DE69023977D1 (de
Inventor
Pierre Louis Beaulieu
Robert Deziel
Pierre Lavallee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Publication of DE69023977D1 publication Critical patent/DE69023977D1/de
Application granted granted Critical
Publication of DE69023977T2 publication Critical patent/DE69023977T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
DE69023977T 1989-07-07 1990-07-03 Antivirale Peptide, die eine 2-Ketoalkylaminosäureseitenkette enthalten. Expired - Fee Related DE69023977T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000605062A CA1340682C (en) 1989-07-07 1989-07-07 Antiviral peptides having a 2-oxoalkyl amino acid side chain

Publications (2)

Publication Number Publication Date
DE69023977D1 DE69023977D1 (de) 1996-01-18
DE69023977T2 true DE69023977T2 (de) 1996-05-15

Family

ID=4140313

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69023977T Expired - Fee Related DE69023977T2 (de) 1989-07-07 1990-07-03 Antivirale Peptide, die eine 2-Ketoalkylaminosäureseitenkette enthalten.

Country Status (8)

Country Link
US (1) US5700780A (de)
EP (1) EP0411332B1 (de)
JP (1) JP2877910B2 (de)
AT (1) ATE131174T1 (de)
AU (1) AU643448B2 (de)
CA (1) CA1340682C (de)
DE (1) DE69023977T2 (de)
IL (1) IL94981A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69019786T2 (de) * 1989-07-07 1995-11-16 Bio Mega Boehringer Ingelheim Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
CA1340681C (en) * 1989-07-07 1999-07-27 Robert Deziel Antiherpes tetrapeptides having a substituted aspartic acid side chain
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
SG42995A1 (en) 1992-03-12 1997-10-17 Bio Mega Boehringer Ingelheim Isosteric antiherpes peptide derivatives
AU6059699A (en) * 1998-09-23 2000-04-10 Regents Of The University Of California, The Synthetic peptides, conjugation reagents and methods
ES2293977T3 (es) 2000-02-07 2008-04-01 Wisconsin Alumni Research Foundation Peptidos antivirales farmacologicamente activos y metodo para su uso.
WO2005060541A2 (en) * 2003-12-01 2005-07-07 Wisconsin Alumni Research Foundation Peptides and methods for inducing cellular resistance to infection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (de) * 1987-05-22 1990-08-22 Merck & Co. Inc. Hemmungsstoff für Ribonukleotid-Reduktase
US4837304A (en) * 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4845195A (en) * 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4814432A (en) * 1987-05-22 1989-03-21 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
EP0357332A3 (de) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin-Inhibitoren zur Behandlung von AIDS durch Hemmung der HIV-Protease
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
CA1340683C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides having a substituted aspartic acid side chain
DE69019786T2 (de) * 1989-07-07 1995-11-16 Bio Mega Boehringer Ingelheim Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
CA1340684C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain

Also Published As

Publication number Publication date
EP0411332A1 (de) 1991-02-06
JP2877910B2 (ja) 1999-04-05
AU5877790A (en) 1991-01-10
IL94981A0 (en) 1991-06-10
ATE131174T1 (de) 1995-12-15
JPH03115296A (ja) 1991-05-16
US5700780A (en) 1997-12-23
AU643448B2 (en) 1993-11-18
DE69023977D1 (de) 1996-01-18
CA1340682C (en) 1999-07-27
IL94981A (en) 1995-03-15
EP0411332B1 (de) 1995-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD., LAVAL, QUEBEC,

8328 Change in the person/name/address of the agent

Free format text: LAUDIEN, D., DIPL.-CHEM. DR.PHIL.NAT., 55127 MAINZ

8339 Ceased/non-payment of the annual fee