ATE116995T1 - Enzyminhibitoren. - Google Patents
Enzyminhibitoren.Info
- Publication number
- ATE116995T1 ATE116995T1 AT90110322T AT90110322T ATE116995T1 AT E116995 T1 ATE116995 T1 AT E116995T1 AT 90110322 T AT90110322 T AT 90110322T AT 90110322 T AT90110322 T AT 90110322T AT E116995 T1 ATE116995 T1 AT E116995T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- derivatives
- hydroxy
- peptide
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/362,171 US5212157A (en) | 1989-06-06 | 1989-06-06 | Enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE116995T1 true ATE116995T1 (de) | 1995-01-15 |
Family
ID=23424961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90110322T ATE116995T1 (de) | 1989-06-06 | 1990-05-31 | Enzyminhibitoren. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5212157A (de) |
EP (1) | EP0401676B1 (de) |
JP (1) | JPH0347196A (de) |
AT (1) | ATE116995T1 (de) |
AU (1) | AU646806B2 (de) |
CA (1) | CA2016656C (de) |
DE (1) | DE69015885T2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516784A (en) * | 1991-08-13 | 1996-05-14 | Schering Corporation | Anti-HIV (AIDS) agents |
NZ249789A (en) * | 1992-03-11 | 1997-07-27 | Narhex Ltd | Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions |
US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
MXPA93002392A (es) | 1992-03-11 | 2005-02-04 | Narhex Ltd | Derivados amino de hidrocarburos-oxo e hidroxi-substituidos. |
US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
US5693815A (en) * | 1993-01-17 | 1997-12-02 | Schering Corporation | Peptides |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
CA2179935C (en) * | 1995-06-30 | 2010-09-07 | Ryohei Kato | Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
US5849691A (en) * | 1996-02-20 | 1998-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II |
US6291432B1 (en) | 1996-12-27 | 2001-09-18 | Japan Energy Corporation | Tripeptide compounds and anti-AIDS medicine |
US6783947B1 (en) | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
JP4459629B2 (ja) | 2002-04-12 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | 二環式アミド |
UY34863A (es) | 2012-06-19 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Antagonistas de iap |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1258748A (en) * | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Renin inhibitory peptides |
US4680284A (en) * | 1985-01-23 | 1987-07-14 | Abbott Laboratories | Modified phenylalanine peptidylaminodiols |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
EP0245361A1 (de) * | 1985-11-15 | 1987-11-19 | The Upjohn Company | Polypeptid-analoge, die renin inhibieren und s-aryl-d- oder -l- oder-d,l-cysteinyl,3-(arylthio)-milchsäure oder 3-(arylthio)alkyl-reste enthalten |
US4894437A (en) * | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
DE3627877A1 (de) * | 1986-07-30 | 1988-02-04 | Hoechst Ag | Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
WO1988003022A1 (en) * | 1986-10-31 | 1988-05-05 | Pfizer Inc. | Relatively low molecular weight polypeptides as renin inhibitors |
FR2614533A1 (fr) * | 1987-04-23 | 1988-11-04 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments |
US5342922A (en) * | 1989-03-08 | 1994-08-30 | Washington University | Inhibitors of retroviral protease |
-
1989
- 1989-06-06 US US07/362,171 patent/US5212157A/en not_active Expired - Lifetime
-
1990
- 1990-05-14 CA CA002016656A patent/CA2016656C/en not_active Expired - Fee Related
- 1990-05-31 DE DE69015885T patent/DE69015885T2/de not_active Expired - Fee Related
- 1990-05-31 AT AT90110322T patent/ATE116995T1/de active
- 1990-05-31 EP EP90110322A patent/EP0401676B1/de not_active Expired - Lifetime
- 1990-06-05 AU AU56289/90A patent/AU646806B2/en not_active Ceased
- 1990-06-05 JP JP2147159A patent/JPH0347196A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69015885D1 (de) | 1995-02-23 |
EP0401676B1 (de) | 1995-01-11 |
EP0401676A1 (de) | 1990-12-12 |
AU5628990A (en) | 1990-12-13 |
AU646806B2 (en) | 1994-03-10 |
CA2016656C (en) | 2000-04-11 |
US5212157A (en) | 1993-05-18 |
DE69015885T2 (de) | 1995-06-08 |
CA2016656A1 (en) | 1990-12-06 |
JPH0347196A (ja) | 1991-02-28 |
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