DE69015885D1 - Enzyminhibitoren. - Google Patents

Enzyminhibitoren.

Info

Publication number
DE69015885D1
DE69015885D1 DE69015885T DE69015885T DE69015885D1 DE 69015885 D1 DE69015885 D1 DE 69015885D1 DE 69015885 T DE69015885 T DE 69015885T DE 69015885 T DE69015885 T DE 69015885T DE 69015885 D1 DE69015885 D1 DE 69015885D1
Authority
DE
Germany
Prior art keywords
amino acid
derivatives
hydroxy
peptide
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015885T
Other languages
English (en)
Other versions
DE69015885T2 (de
Inventor
Paul Cates Anderson
Yvan Guindon
Christiane Yoakim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Mega Boehringer Ingelheim Research Inc
Original Assignee
Bio Mega Boehringer Ingelheim Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim Research Inc filed Critical Bio Mega Boehringer Ingelheim Research Inc
Application granted granted Critical
Publication of DE69015885D1 publication Critical patent/DE69015885D1/de
Publication of DE69015885T2 publication Critical patent/DE69015885T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69015885T 1989-06-06 1990-05-31 Enzyminhibitoren. Expired - Fee Related DE69015885T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/362,171 US5212157A (en) 1989-06-06 1989-06-06 Enzyme inhibitors

Publications (2)

Publication Number Publication Date
DE69015885D1 true DE69015885D1 (de) 1995-02-23
DE69015885T2 DE69015885T2 (de) 1995-06-08

Family

ID=23424961

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015885T Expired - Fee Related DE69015885T2 (de) 1989-06-06 1990-05-31 Enzyminhibitoren.

Country Status (7)

Country Link
US (1) US5212157A (de)
EP (1) EP0401676B1 (de)
JP (1) JPH0347196A (de)
AT (1) ATE116995T1 (de)
AU (1) AU646806B2 (de)
CA (1) CA2016656C (de)
DE (1) DE69015885T2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516784A (en) * 1991-08-13 1996-05-14 Schering Corporation Anti-HIV (AIDS) agents
EP0633881B1 (de) * 1992-03-11 2003-10-29 Narhex Limited Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
US5693815A (en) * 1993-01-17 1997-12-02 Schering Corporation Peptides
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5932550A (en) * 1995-06-30 1999-08-03 Japan Energy Corporation Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US6222043B1 (en) 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
US5849691A (en) * 1996-02-20 1998-12-15 The United States Of America As Represented By The Department Of Health And Human Services Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II
US6291432B1 (en) 1996-12-27 2001-09-18 Japan Energy Corporation Tripeptide compounds and anti-AIDS medicine
US6783947B1 (en) 1999-09-09 2004-08-31 Dade Behring Marburg Gmbh Protecting groups for biological labeling
JP4459629B2 (ja) 2002-04-12 2010-04-28 メルク エンド カムパニー インコーポレーテッド 二環式アミド
TW201402613A (zh) 2012-06-19 2014-01-16 必治妥美雅史谷比公司 Ｉａｐ拮抗劑

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4680284A (en) * 1985-01-23 1987-07-14 Abbott Laboratories Modified phenylalanine peptidylaminodiols
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
JPS63501364A (ja) * 1985-11-15 1988-05-26 ジ・アップジョン・カンパニ− Ｓ−アリ−ル−ｄ−またはｌ−またはｄｌ−システイニル、３−（アリ−ルチオ）乳酸または３−（アリ−ルチオ）アルキル基を含有する新規レニン阻害ポリペプチド同族体
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
BE1002213A5 (fr) * 1987-04-23 1990-10-16 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
US5342922A (en) * 1989-03-08 1994-08-30 Washington University Inhibitors of retroviral protease

Also Published As

Publication number Publication date
AU646806B2 (en) 1994-03-10
US5212157A (en) 1993-05-18
EP0401676B1 (de) 1995-01-11
DE69015885T2 (de) 1995-06-08
CA2016656A1 (en) 1990-12-06
ATE116995T1 (de) 1995-01-15
CA2016656C (en) 2000-04-11
AU5628990A (en) 1990-12-13
JPH0347196A (ja) 1991-02-28
EP0401676A1 (de) 1990-12-12

Similar Documents

Publication Publication Date Title
DE69015885T2 (de) Enzyminhibitoren.
FI915819A (fi) Hiv- proteas-inhibitorer.
ES2139195T3 (es) Derivados de sulfonamidas como inhibidores de la aspartil-proteasa.
DE122007000045I1 (de) Hydroxyethylaminosulfonamide verwendbar als Inhibitoren retroviraler Proteasen
ATE116332T1 (de) Enzym-inhibierende peptid-derivate.
YU9301A (sh) Peptidi kao inhibitori hepatitisa c
ATE123275T1 (de) Substituierte pyrrolidinderivate als hiv-protease-hemmer.
EA199800661A1 (ru) Ингибиторы аспартильных протеаз
DK0399556T3 (da) Aminosubstituerede heterocycliske forbindelser som renininhibitorer
FI944187A (fi) Isosteeriset antiherpespeptidijohdannaiset
AU643448B2 (en) Antiviral peptides having a 2-Oxoalkyl amino acid side chain
EA199800168A1 (ru) Производные пеницилламинамида
KR950011464A (ko) 비가역적 에이치아이브이(hiv) 프로테아제 억제제
ATE106386T1 (de) Gem-diamino-derivate und ihre verwendung bei der herstellung von retro-inverso-peptiden.
CA2019005A1 (en) Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
FI944076A (fi) Menetelmä terapeuttisesti käytt¦kelpoisten N-(3-hydroksi-4-piperidinyyli)(dihydrobentsofuraani-, dihydro-2H-bentsopyraani- tai dihydrobentsodioksiini)karboksamidijohdannaisten valmistamiseksi ja välituote
JPS6419075A (en) L-alanyl-(2alpha,3alphabeta,7alphabeta)-octahydro-1h-indole-2(s)-carboxylic acid derivative as hypotensor

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee