JPH05506651A - 新規化合物 - Google Patents
新規化合物Info
- Publication number
- JPH05506651A JPH05506651A JP91506973A JP50697391A JPH05506651A JP H05506651 A JPH05506651 A JP H05506651A JP 91506973 A JP91506973 A JP 91506973A JP 50697391 A JP50697391 A JP 50697391A JP H05506651 A JPH05506651 A JP H05506651A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- compound
- hydrogen
- phosphonopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 32
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 23
- -1 t-butoxycarbonyl Chemical group 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- 239000012453 solvate Substances 0.000 claims description 13
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
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- 125000003118 aryl group Chemical group 0.000 claims description 5
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
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- LMUUOLPFDRQPTC-ULQDDVLXSA-N [(1s)-1-[[(2s)-4-methyl-1-oxo-1-[[(9s)-8-oxo-1,7-diazacyclotridec-9-yl]amino]pentan-2-yl]amino]ethyl]phosphonic acid Chemical compound OP(=O)(O)[C@@H](C)N[C@@H](CC(C)C)C(=O)N[C@H]1CCCCNCCCCCNC1=O LMUUOLPFDRQPTC-ULQDDVLXSA-N 0.000 claims 1
- RQNKISSEPZPZDA-BZSNNMDCSA-N [(1s)-1-[[(2s)-4-methyl-1-oxo-1-[[(9s)-8-oxo-1,7-diazacyclotridec-9-yl]amino]pentan-2-yl]amino]propyl]phosphonic acid Chemical compound CC[C@H](P(O)(O)=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCCCNCCCCCNC1=O RQNKISSEPZPZDA-BZSNNMDCSA-N 0.000 claims 1
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909008065A GB9008065D0 (en) | 1990-04-10 | 1990-04-10 | Novel compounds |
| GB9008065.6 | 1990-04-10 | ||
| PCT/GB1991/000529 WO1991015506A1 (fr) | 1990-04-10 | 1991-04-05 | Phosphonopeptides avec activite inhibitrice de la collagenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05506651A true JPH05506651A (ja) | 1993-09-30 |
Family
ID=10674178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP91506973A Pending JPH05506651A (ja) | 1990-04-10 | 1991-04-05 | 新規化合物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0527761A1 (fr) |
| JP (1) | JPH05506651A (fr) |
| AU (1) | AU637903B2 (fr) |
| CA (1) | CA2080228A1 (fr) |
| GB (1) | GB9008065D0 (fr) |
| IE (1) | IE911165A1 (fr) |
| NZ (1) | NZ237732A (fr) |
| PT (1) | PT97281A (fr) |
| WO (1) | WO1991015506A1 (fr) |
| ZA (1) | ZA912574B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0520573A1 (fr) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Dérivés d'imides cycliques |
| GB9122859D0 (en) * | 1991-10-28 | 1991-12-11 | Smithkline Beecham Plc | Novel compounds |
| US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
| US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8726714D0 (en) * | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| EP0401963A1 (fr) * | 1989-04-13 | 1990-12-12 | Beecham Group p.l.c. | Phosphonopeptides avec activité inhibitrice de collagénase |
-
1990
- 1990-04-10 GB GB909008065A patent/GB9008065D0/en active Pending
-
1991
- 1991-04-05 WO PCT/GB1991/000529 patent/WO1991015506A1/fr not_active Application Discontinuation
- 1991-04-05 EP EP91907169A patent/EP0527761A1/fr not_active Ceased
- 1991-04-05 JP JP91506973A patent/JPH05506651A/ja active Pending
- 1991-04-05 AU AU76502/91A patent/AU637903B2/en not_active Ceased
- 1991-04-05 CA CA002080228A patent/CA2080228A1/fr not_active Abandoned
- 1991-04-08 IE IE116591A patent/IE911165A1/en unknown
- 1991-04-08 ZA ZA912574A patent/ZA912574B/xx unknown
- 1991-04-08 PT PT97281A patent/PT97281A/pt not_active Application Discontinuation
- 1991-04-08 NZ NZ237732A patent/NZ237732A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9008065D0 (en) | 1990-06-06 |
| IE911165A1 (en) | 1991-10-23 |
| EP0527761A1 (fr) | 1993-02-24 |
| CA2080228A1 (fr) | 1991-10-11 |
| PT97281A (pt) | 1992-01-31 |
| AU637903B2 (en) | 1993-06-10 |
| ZA912574B (en) | 1992-10-28 |
| AU7650291A (en) | 1991-10-30 |
| NZ237732A (en) | 1993-08-26 |
| WO1991015506A1 (fr) | 1991-10-17 |
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