ZA912574B - Phosphonopeptides with collagenase inhibiting activity - Google Patents

Phosphonopeptides with collagenase inhibiting activity

Info

Publication number
ZA912574B
ZA912574B ZA912574A ZA912574A ZA912574B ZA 912574 B ZA912574 B ZA 912574B ZA 912574 A ZA912574 A ZA 912574A ZA 912574 A ZA912574 A ZA 912574A ZA 912574 B ZA912574 B ZA 912574B
Authority
ZA
South Africa
Prior art keywords
phosphonopeptides
inhibiting activity
collagenase inhibiting
collagenase
activity
Prior art date
Application number
ZA912574A
Other languages
English (en)
Inventor
Roger Edward Markwell
Edward Markwell Roger
Shahzad Sharooq Rahman
Sharooq Rahman Shahzad
Robert William Ward
William Ward Robert
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of ZA912574B publication Critical patent/ZA912574B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA912574A 1990-04-10 1991-04-08 Phosphonopeptides with collagenase inhibiting activity ZA912574B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909008065A GB9008065D0 (en) 1990-04-10 1990-04-10 Novel compounds

Publications (1)

Publication Number Publication Date
ZA912574B true ZA912574B (en) 1992-10-28

Family

ID=10674178

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA912574A ZA912574B (en) 1990-04-10 1991-04-08 Phosphonopeptides with collagenase inhibiting activity

Country Status (10)

Country Link
EP (1) EP0527761A1 (fr)
JP (1) JPH05506651A (fr)
AU (1) AU637903B2 (fr)
CA (1) CA2080228A1 (fr)
GB (1) GB9008065D0 (fr)
IE (1) IE911165A1 (fr)
NZ (1) NZ237732A (fr)
PT (1) PT97281A (fr)
WO (1) WO1991015506A1 (fr)
ZA (1) ZA912574B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520573A1 (fr) * 1991-06-27 1992-12-30 Glaxo Inc. Dérivés d'imides cycliques
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5827840A (en) * 1996-08-01 1998-10-27 The Research Foundation Of State University Of New York Promotion of wound healing by chemically-modified tetracyclines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (fr) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides avec activité inhibitrice de collagénase

Also Published As

Publication number Publication date
CA2080228A1 (fr) 1991-10-11
AU637903B2 (en) 1993-06-10
NZ237732A (en) 1993-08-26
PT97281A (pt) 1992-01-31
WO1991015506A1 (fr) 1991-10-17
AU7650291A (en) 1991-10-30
GB9008065D0 (en) 1990-06-06
JPH05506651A (ja) 1993-09-30
IE911165A1 (en) 1991-10-23
EP0527761A1 (fr) 1993-02-24

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