JPH05501879A - Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物 - Google Patents

Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物

Info

Publication number
JPH05501879A
JPH05501879A JP2515011A JP51501190A JPH05501879A JP H05501879 A JPH05501879 A JP H05501879A JP 2515011 A JP2515011 A JP 2515011A JP 51501190 A JP51501190 A JP 51501190A JP H05501879 A JPH05501879 A JP H05501879A
Authority
JP
Japan
Prior art keywords
amino
methyl
carbonyl
hydroxy
iie
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2515011A
Other languages
English (en)
Japanese (ja)
Inventor
ハインリクソン，ロバート・リーロイ
トマッセリー，アルフレッド・ガイゼッペ
ソーヤー，トミ・キム
ショステアーツ，ハインリッチ・ヨセフ
タイスリボングス，スービット
ヘスター，ジャクソン・ビィ・ジュニア
フイ，ジョン・オン―チン
タープレイ，ウィリアム・ゲーリー
テン・ブリンク，ルース・エリザベス
Original Assignee
ジ・アップジョン・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジ・アップジョン・カンパニー filed Critical ジ・アップジョン・カンパニー
Publication of JPH05501879A publication Critical patent/JPH05501879A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2515011A 1989-10-27 1990-10-16 Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物 Pending JPH05501879A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42829189A 1989-10-27 1989-10-27
US428,291 1989-10-27

Publications (1)

Publication Number Publication Date
JPH05501879A true JPH05501879A (ja) 1993-04-08

Family

ID=23698278

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2515011A Pending JPH05501879A (ja) 1989-10-27 1990-10-16 Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物

Country Status (5)

Country Link
EP (1) EP0497835A1 (fr)
JP (1) JPH05501879A (fr)
AU (1) AU6633490A (fr)
CA (1) CA2066644A1 (fr)
WO (1) WO1991006561A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
RU2126794C1 (ru) * 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
DE4215874A1 (de) * 1992-05-14 1993-11-18 Bayer Ag Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
ES2180600T3 (es) * 1994-10-19 2003-02-16 Novartis Ag Eteres de isosteros substrato de aspartato proteasa antivirales.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
EP0144290A3 (fr) * 1983-12-01 1987-05-27 Ciba-Geigy Ag Dérivés éthylènediamine substitués
DE3812328A1 (de) * 1988-04-14 1989-10-26 Merck Patent Gmbh Aminosaeurederivate

Also Published As

Publication number Publication date
EP0497835A1 (fr) 1992-08-12
WO1991006561A1 (fr) 1991-05-16
CA2066644A1 (fr) 1991-04-28
AU6633490A (en) 1991-05-31

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