JPH05286832A - Hair-raising agent - Google Patents

Abstract

PURPOSE:To provide the hair-raising agent excellent in the effects on hair growth, hair raising, alopecia prevention, dander prevention, etc. The compounding ratio of the extract of Aconiti Tuber to the extract of the pericarp of Randium domesticajack verduk, etc., is suitably selected in response to the agent type of the hair-raising agent. But, the extract of the Aconiti Tuber is preferably compounded in an amount of 0.0001-20.0wt.% (expressed in terms of dried product) based on the total amount of the hair-raising agent, and the extract of the pericarp of the Randium domesticajack verduk, etc., is also preferably compounded in an amount of 0.01-10.0wt.% (expressed in terms of dried product). CONSTITUTION:The hair-raising agent comprises by compounding, the extract of the Aconiti Tuber and the extract of the percarp of the Randium domesticajack verduk or Randium domesticajack verlancer.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent which is excellent in hair growth effect, hair nourishing effect, hair loss prevention, dandruff prevention and the like.

[0002]

2. Description of the Related Art Alopecia is considered to be caused by various factors intricately intertwined with each other, and the occurrence mechanism is not yet fully understood. Conventionally, a hair nourishing agent containing various agents has been used for the prevention and treatment of hair loss, but a drug effective enough to suppress hair loss and promote hair growth and hair nourishment has not yet been found.

[0003] The fusi, which is used as a raw material for the hair nourishing agent of the present invention, has been described in China since ancient times as a herbal sutra and is known as an important crude drug that is widely used in various Kampo prescriptions in Kampo medicine. ) Aconitum species (Aconitum specie)
s) tuberous root. Japanese Patent Application Laid-Open No. 3-271213 proposes a hair-growing and hair-growing agent characterized by containing an extract of root, stem or leaf of the aconite, which is the basic plant, but the extract of aconite alone is used. The hair growth and hair growth effects were insufficient.

[0004]

DISCLOSURE OF THE INVENTION The inventors of the present invention have made extensive studies in view of the above circumstances, and as a result, the extract of apricot and the peel of Randum domesticus jack barduke or Randum domesticus jack bar balancer It was found that the combination with the obtained extract is highly safe, exhibits an excellent effect on promoting mouse hair growth and human hair growth, and further exhibits a marked effect on the antidandruff effect. The present invention has been completed. That is, the object of the present invention is to
It is to provide a hair nourishing agent having excellent effects such as hair growth, hair nourishment, hair loss prevention, and dandruff prevention.

[0005]

SUMMARY OF THE INVENTION The present invention comprises a mixture of an extract of Fuzi and an extract obtained from the skin of Randium domesticus camouflage barduke or Randium domesticus camouflage baransa. It is hair.

[0006] The ingredient of the crude drug used for the hair nourishing agent of the present invention is the aconitum species of the genus Ranunculaceae (Aconitum species).
As long as it is prepared from the root tuber, the origin and the place of origin thereof are not limited. Further, in general, aconite plants contain a highly toxic aconitine alkaloid, and since careful attention is required when using the aconitine alkaloid, it is more preferable to use a processed astringent prepared by detoxification such as heat treatment. It is better to use what is called.

[0007] Examples of the root plant of Fuzi are, for example, the cultivar Aconitum c.
armichaeli Debx), a wild species (Aconitum kusnezoffii Rei) from all over China.
chb. ), Etc. from Korea.
itum triphyllum Nakai), Aconitum coreanum
Rap. ), Japanese octopus beetle (Aconitu)
m japonicum Thunb. ), Aconitum chinese Pax
t. ) And the like. Particularly, the agar beetle produced in Sichuan Province of China is preferable in terms of quality stability and supply with a certain cultivation method.

As the detoxification processing method, Japanese Patent Publication No. 37
No. 18498 proposed, tuber roots in an autoclave at 100 to 130 ° C., pressure 1.0 to 1.5 kg / c.
The method of preparing by applying pressure and heat treatment for 20 to 40 minutes is a particularly preferable method because it is possible to stably produce a crude drug which is simple, effective and safe. As an example of the product prepared by this method, the product name “Processed Bushi powder” of the Japanese Pharmacopoeia standard product
Is mentioned. Also, as a method mainly performed in China, water-washed tuberous roots are dipped in bitter broth for several days to dry, or further steamed, boiled or otherwise subjected to repeated treatments and then dried or prepared. There is a method in which it is prepared by washing with water, dividing it vertically, immersing it in ash when fresh, and applying heat, pressure, etc. to dry it. As an example prepared by this method, a commercially available product of Fuzi gourd produced in Sichuan Province of China (referred to as Fuzi Fuzi in Japan) is preferable because it is sufficiently detoxified with a certain quality.

The extract of the adzuki bean of the present invention refers to a component which is transferred from the adduct to the solvent when the advent is extracted with a solvent, and this extract is used in a dry state after removing the solvent. It can also be used in the state of being dissolved in a solvent. In the latter case, the extraction solvent will form part of the base in the hair restorer of the invention.

Solvents include water, alcohols such as methanol, ethanol, butanol ethers such as diethyl ether, dioxane, ketones such as acetone aliphatic hydrocarbons such as pentane, hexane, cyclohexane, esters such as ethyl acetate. Etc. can be used. When the extract is removed by solvent and used as a dried product, any of the above-mentioned solvents can be used alone or in combination. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

Upon extraction, the adjunct may be used as it is, or may be crushed or crushed to improve contact with a solvent. Although the ratio of the adjunct to the solvent is not particularly limited, the adjunct 1 is taken into consideration from the viewpoint of extraction efficiency and convenience.
Preference is given to using 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time is preferably in the range of 30 minutes to 2 weeks, although it varies depending on the extraction temperature, the presence or absence of stirring and the like.

Further, the extract obtained from the skin of Randium domesticus camber bar duke or Randium domesticus camouflage bar balancer used in the hair nourishing composition of the present invention is described in JP-A-60-243020. It is a known 5α-reductase activity inhibitor and is a known substance. The production method is described in the same publication, and it is extracted with ethanol, hexane, ethyl acetate or the like. Other extraction solvents may be suitable for each operation, for example, pentane, hexane,
Heptane, aliphatic hydrocarbons such as cyclohexane, aromatic hydrocarbons such as benzene, toluene, xylene, halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, lower alcohols such as methanol and ethanol, Water, diethyl ether, petroleum ether, ethyl acetate, acetone or a mixed solvent of two or more of these may be mentioned.

Although not all the components of these pericarps have been elucidated, the major ones have been isolated and their structures have been determined. As a main component, radisic acid and its glycosides such as landioside A, B and C are known. All of these substances have physiological activity, and they can be used as an extract as in JP-A-60-243020 or in the form of isolated individual components. Further, the main component, Langic acid, and its glycosides, Landeosides A, B and C, have physiological activity and can be used.

Although the method for producing the extract of the skin of Randium domesticus camouflage barduke or Randium domesticus camouflage jack bar balancer of the present invention is not specified as described above, a reference example of the extraction method Is described below. Reference example 1. (Extraction with ethanol) 50 g of dried Randium Domesticum Jack Burduke pericarp was crushed and immersed in 200 ml of ethanol,
It was left at room temperature for 1 week. The mixture was filtered, and the filtrate was concentrated under reduced pressure to give 5.5 g of an oily substance.

Reference Example 2. (Extraction with Hexane) 950 g of dried Randium Domesticum Jack Burduke pericarp was crushed and continuously extracted with hexane for 5 hours using a Soxhlet extractor, and the extract was concentrated under reduced pressure to obtain 120 g of an oily substance. Obtained.

Reference Example 3. (Extraction of Langicic Acid) 5.5 kg of dried Randum domestica camjack Burduke's peel was crushed to obtain 12,000 m of ethyl acetate.
1. Soak overnight in 1 and repeat 3 times to combine solution 3
Ethyl acetate was distilled off from 6,000 ml to give an oily substance 92
0 g was obtained. The obtained oily substance was dissolved in hexane, and 2
The mixture was extracted 3 times with a 0% aqueous potassium hydroxide solution, the aqueous layer was washed twice with hexane to remove neutral substances, and then the aqueous layer was acidified with concentrated hydrochloric acid and then extracted with ethyl acetate. The extract was concentrated under reduced pressure, and the obtained residue was crystallized using hexane to obtain 110 g of crude crystals of Langic acid. The crude crystals were recrystallized from a mixed liquid of ethanol and water (3: 1) to obtain 92 g of Langic acid.

Reference Example 4. (Landioside A, B and C
Extraction of Reference Example 2. The oily substance obtained in 1. was purified by silica gel column chromatography. After elution of the portion containing Langic acid using a mixed solution of ethyl acetate and hexane (2: 8) as an eluting solvent, the elution solvent was gradually changed from a mixed solution of ethyl acetate and hexane (1: 1) to ethyl acetate. Finally, the ratio was changed to ethyl acetate alone to elute 40 g of the portion containing landiosides A, B and C. The eluate was added to J. Org. Chem. , 48, 44
6 (1983) to obtain Landioside A, B and C.

The present inventor has conducted extensive studies on the above-mentioned constituents to be incorporated in the hair nourishment, and as a result, the extract of the adzuki bean of the present invention and Randium domesticus came barduke or Randeum domesticus camber bar balancer It was found that the hair nourishing agent containing the extract obtained from the pericarp has a synergistic effect on hair growth effect, hair nourishing effect, hair loss prevention, dandruff prevention effect and the like.

In addition, the compounding ratio of the extract of the aconcise of the present invention and the extract obtained from the skin of Randium domestica camouflage barduke or Randium domestica camouflage jack bar lancer depends on the formulation of the hair restorer, etc. Depending on the total amount of the hair nourishing agent, the extract of Fuzi is 0.0001 to 20.0 wt% (converted to dry matter), Randium domesticus camouflage barduke or Landeum domes. The extract obtained from the skin of Chicom jack bar balancer may be 0.01 to 10.0 wt% (dry matter conversion), and if it is less than the lower limit of the respective blending amounts, the effect aimed at by the present invention may be obtained. On the other hand, even if the upper limit is exceeded, improvement in the effect commensurate with the increased amount cannot be expected.

The hair nourishing agent of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a shampoo, a rinse, a hair foam and a hair gel according to a conventional method.

The hair nourishing agent of the present invention includes pigments, fragrances, germicides, preservatives, keratolytic agents, anti-inflammatory agents, anti-androgens,
Hair nourishing agents, vitamins, antioxidants, cooling agents, extracts of other herbal medicines and the like can be appropriately added within the range that achieves the object of the present invention.

[0022]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) Mouse Hair Growth Promoting Effect Test C3H mice (male, 7 weeks old) were shaved with a hair clipper and a shaver on the central back hair of each mouse, and the sample was cut at the shaved site once a day per animal. 0.2 ml was applied. For each sample, 10 animals were used per group. On the fifteenth day after the start of the experiment, the back of the mouse was photographed, the hair cutting area and the hair growth area were calculated, the hair growth rate (%) was calculated, and the hair growth promoting effect was determined by the average value of 10 cases.

(2) Human hair growth promoting effect test method 10 hair test subjects who are male pattern baldness have circular hair with a diameter of 1 cm at 5 cm above the ears of the head. About 3 ml of the sample of Example or Comparative Example was applied to the left side of the shaved test site twice daily in the morning and evening, and compared with the untreated right side. Evaluation of the effect is 28 days after the start of the test,
20 hairs on each of the left and right test sites are shaved, and the average value (B) of the lengths of 20 hairs on the left side (applied Example or Comparative Example) is calculated as the length of 20 hairs on the right side (untreated). The value obtained by dividing the average value (A) of the sacks was obtained and evaluated. The determination result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method 20 heads of androgenetic alopecia patients were applied with the sample twice daily in the morning and evening and continuously for 6 months to evaluate the effect. The test results were "hair bristling or increased hair loss", "less hair loss", "less dandruff" for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect. The number of people who answered

Production Example 1 (Preparation of extract of Fuzi) (1) A crushed product of dried root of Fuzi produced in Sichuan Province of China (commercially available as river crow or dried zizi) in an autoclave at 100 to 130 ° C. 1 to 1.5 kg / cm2,
Pressurize and heat treatment for 40 minutes. Azushi 100 processed
g to 1500 ml of 70 v / v% ethanol (hereinafter, v
/ V% is abbreviated to%) at room temperature (20 to 25 ° C.) for 16 hours, the supernatant liquid is collected by filtration, concentrated at 45 ° C. under reduced pressure for 3 hours, and the solvent is distilled off. The brown extract to 11.
7 g was obtained.

(2) Preparation Example 1 100 g of Zhifu Province from China which was processed in the same manner as in (1) was immersed in 1500 ml of 40% ethanol for 16 hours at room temperature (20 to 25 ° C.),
The supernatant was collected by filtration and concentrated under reduced pressure at 45 ° C. for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

(3) 50 g of Zhuzi (commercially available as Zhizi) produced in Sichuan Province of China was immersed in 500 ml of 70% ethanol for 16 hours at room temperature (20 to 25 ° C.), and the supernatant was filtered. After collecting and concentrating at 45 ° C. under reduced pressure for 2 hours and distilling off the solvent, 5.3 g of a brown extract was obtained.

(4) Japanese non-Pharmacopoeia standard product processed bush powder 50
g to 500 ml of 40% ethanol at room temperature (20-2
After dipping at 5 ° C. for 10 hours, the supernatant was collected by filtration, concentrated under reduced pressure at 45 ° C. for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

Examples 1 to 9 and Comparative Examples 1 to 8 (Heartnick) Prepared in accordance with the extract of the fusi prepared in Production Example 1 and the Japanese Patent Laid-Open No. 60-243020 in the following component compositions. And a mixture of Landgiosides A, B and C (hereinafter abbreviated as LS, Reference Example 4), an ethanol extract of fruit skin (hereinafter referred to as LAEE) Reference examples 1) and hexane extracted extracts (hereinafter, abbreviated as LAHE, reference example 2) and the like were blended to prepare respective hair nicks, and the above-mentioned various tests were carried out.

(1) Composition Component content (wt%) ──────────────────────────────────── Ethanol 60.0 Extract of Fuzi, extract obtained from pericarp, etc. See Table 1 and Table 2 Propylene glycol 1.0 Perfume 0.1 Purified water Remaining amount to make total amount 100.0 ──────── ────────────────────────────

(2) Preparation method The extract of Fuzi, the extract obtained from the peel and the fragrance are dissolved in ethanol, and propylene glycol is dissolved in purified water. The solutions are uniformly mixed with stirring. A hair nick was prepared.

(3) Characteristics As shown in Tables 1 and 2, the results obtained by conducting various tests of each Hearthnic were obtained from Comparative Examples 1 to 4 and pericarps, which were the formulations of the extract of the fusi of the present invention alone. In Comparative Examples 5 to 8 in which the extract was alone, the hair growth promoting effect was low, and the hair nourishing and dandruff preventing effects were not observed. On the other hand, the hair nourishing agents of the present invention of Examples 1 to 9 in which the extract of Fuzi of the present invention and the extract obtained from the pericarp are simultaneously mixed show a high hair growth promoting effect in mice and humans, and are practically used. The test results also showed good results. In addition, in Examples 1 to 9, skin irritation did not occur in various tests on human skin.

[0034]

[Table 1]

[0035]

[Table 2]

[0036]

EFFECTS OF THE INVENTION As described above, it is apparent that the present invention provides a hair nourishing agent which exhibits a remarkable hair growth promoting effect and is excellent in hair growth effect, hair loss prevention and dandruff prevention effect.

Claims (1)

[Claims] 1. A hair nourishing agent comprising a mixture of an extract of Bushi and an extract obtained from the skin of Randum domesticus camiva var.