JPH0481993B2 - - Google Patents
Info
- Publication number
- JPH0481993B2 JPH0481993B2 JP59227640A JP22764084A JPH0481993B2 JP H0481993 B2 JPH0481993 B2 JP H0481993B2 JP 59227640 A JP59227640 A JP 59227640A JP 22764084 A JP22764084 A JP 22764084A JP H0481993 B2 JPH0481993 B2 JP H0481993B2
- Authority
- JP
- Japan
- Prior art keywords
- prazosin hydrochloride
- organic solvent
- group
- crystal
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI842544A FI79107C (fi) | 1984-06-25 | 1984-06-25 | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
| FI842544 | 1984-06-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6115881A JPS6115881A (ja) | 1986-01-23 |
| JPH0481993B2 true JPH0481993B2 (enExample) | 1992-12-25 |
Family
ID=8519293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59227640A Granted JPS6115881A (ja) | 1984-06-25 | 1984-10-29 | 無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4739055A (enExample) |
| JP (1) | JPS6115881A (enExample) |
| AT (1) | AT389117B (enExample) |
| AU (1) | AU566814B2 (enExample) |
| BE (1) | BE900925A (enExample) |
| CH (1) | CH661045A5 (enExample) |
| DE (1) | DE3429415A1 (enExample) |
| FI (1) | FI79107C (enExample) |
| FR (1) | FR2567124B1 (enExample) |
| GB (1) | GB2160861B (enExample) |
| IL (1) | IL73267A (enExample) |
| IT (1) | IT1224142B (enExample) |
| LU (1) | LU85616A1 (enExample) |
| NL (1) | NL8403250A (enExample) |
| NZ (1) | NZ209962A (enExample) |
| PT (1) | PT79411B (enExample) |
| ZA (1) | ZA85910B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3683760D1 (de) * | 1986-03-21 | 1992-03-12 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
| JP2756846B2 (ja) * | 1989-12-28 | 1998-05-25 | 住化ファインケム株式会社 | 無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法 |
| JPH07206857A (ja) * | 1993-12-28 | 1995-08-08 | Synthelabo Sa | アルフゾシン塩酸塩の二水和物 |
| SI1953162T1 (sl) * | 2001-02-24 | 2012-09-28 | Boehringer Ingelheim Pharma | Ksantinski derivati, njihova priprava in njihova uporaba kot zdravila |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) * | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| BRPI0711558A2 (pt) * | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| NZ600126A (en) * | 2007-08-17 | 2013-12-20 | Boehringer Ingelheim Int | Purine derivatives for use in the treatment of fap-related diseases |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR101657960B1 (ko) * | 2008-08-15 | 2016-09-20 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｆａｂ-관련 질환의 치료에 사용하기 위한 푸린 유도체 |
| AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP2382216A1 (en) | 2008-12-23 | 2011-11-02 | Boehringer Ingelheim International GmbH | Salt forms of organic compound |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| EA034869B1 (ru) | 2009-11-27 | 2020-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин |
| MX341025B (es) | 2010-05-05 | 2016-08-04 | Boehringer Ingelheim Int Gmbh * | Terapia de combinacion. |
| PH12012502524A1 (en) | 2010-06-24 | 2014-02-10 | Boehringer Ingelheim Int | Diabetes therapy |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| EP3517539B1 (en) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE156532C (enExample) * | ||||
| US2969375A (en) * | 1961-01-24 | Certification of correction | ||
| BE427505A (enExample) * | 1937-05-25 | |||
| GB1156973A (en) * | 1965-07-06 | 1969-07-02 | Quinazoline Derivatives | |
| US3433788A (en) * | 1966-04-27 | 1969-03-18 | Union Carbide Corp | Process for recovery of amines from aqueous solutions by solvent treatment and distillation |
| US3421983A (en) * | 1967-03-07 | 1969-01-14 | Lummus Co | Azeotropic distillation of aqueous toluene diamine |
| US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3743672A (en) * | 1970-05-27 | 1973-07-03 | Halcon International Inc | Separation of water in alkylene glycol mono and diester purification by azeotropic distillation |
| GB1308718A (en) * | 1970-07-01 | 1973-03-07 | Sir Soc Italiana Resine Spa | Method of separating vinyl acetate from liquid mixtures |
| IT956765B (it) * | 1972-06-22 | 1973-10-10 | Montedison Spa | Procedimento per la purificazione di 1 3 diossolano |
| US3935213A (en) * | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4001237A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | Oxazole, isoxazole, thiazole and isothiazole amides |
| US4092315A (en) * | 1976-03-01 | 1978-05-30 | Pfizer Inc. | Novel crystalline forms of prazosin hydrochloride |
| FI67699C (fi) * | 1979-01-31 | 1985-05-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan |
| FI64367C (fi) * | 1980-02-26 | 1986-08-05 | Orion Yhtymae Oy | Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid |
-
1984
- 1984-06-25 FI FI842544A patent/FI79107C/fi not_active IP Right Cessation
- 1984-08-09 DE DE19843429415 patent/DE3429415A1/de active Granted
- 1984-10-03 GB GB08424999A patent/GB2160861B/en not_active Expired
- 1984-10-15 US US06/660,871 patent/US4739055A/en not_active Expired - Lifetime
- 1984-10-19 AU AU34510/84A patent/AU566814B2/en not_active Ceased
- 1984-10-19 IL IL73267A patent/IL73267A/xx not_active IP Right Cessation
- 1984-10-23 NZ NZ209962A patent/NZ209962A/en unknown
- 1984-10-24 IT IT23292/84A patent/IT1224142B/it active
- 1984-10-25 NL NL8403250A patent/NL8403250A/nl not_active Application Discontinuation
- 1984-10-26 CH CH5142/84A patent/CH661045A5/de not_active IP Right Cessation
- 1984-10-26 FR FR8416401A patent/FR2567124B1/fr not_active Expired - Lifetime
- 1984-10-26 PT PT79411A patent/PT79411B/pt not_active IP Right Cessation
- 1984-10-29 LU LU85616A patent/LU85616A1/fr unknown
- 1984-10-29 JP JP59227640A patent/JPS6115881A/ja active Granted
- 1984-10-29 BE BE0/213911A patent/BE900925A/fr not_active IP Right Cessation
- 1984-10-30 AT AT0344184A patent/AT389117B/de not_active IP Right Cessation
-
1985
- 1985-02-06 ZA ZA85910A patent/ZA85910B/xx unknown
-
1988
- 1988-02-08 US US07/153,780 patent/US4873330A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BE900925A (fr) | 1985-02-15 |
| NL8403250A (nl) | 1986-01-16 |
| FI79107C (fi) | 1989-11-10 |
| IT8423292A0 (it) | 1984-10-24 |
| LU85616A1 (fr) | 1985-06-04 |
| DE3429415A1 (de) | 1986-01-02 |
| CH661045A5 (de) | 1987-06-30 |
| IT1224142B (it) | 1990-09-26 |
| FI842544L (fi) | 1985-12-26 |
| ZA85910B (en) | 1985-09-25 |
| PT79411B (en) | 1986-09-15 |
| NZ209962A (en) | 1987-06-30 |
| AU3451084A (en) | 1986-01-02 |
| FR2567124B1 (fr) | 1990-09-21 |
| FI842544A0 (fi) | 1984-06-25 |
| US4873330A (en) | 1989-10-10 |
| GB8424999D0 (en) | 1984-11-07 |
| AT389117B (de) | 1989-10-25 |
| IL73267A0 (en) | 1985-01-31 |
| IL73267A (en) | 1988-06-30 |
| PT79411A (en) | 1984-11-01 |
| AU566814B2 (en) | 1987-10-29 |
| GB2160861B (en) | 1987-11-18 |
| GB2160861A (en) | 1986-01-02 |
| FR2567124A1 (fr) | 1986-01-10 |
| JPS6115881A (ja) | 1986-01-23 |
| DE3429415C2 (enExample) | 1990-05-03 |
| US4739055A (en) | 1988-04-19 |
| ATA344184A (de) | 1989-03-15 |
| FI79107B (fi) | 1989-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4873330A (en) | A process for the preparation of anhydrous, stable, crystalline delta-form of prazosin hydrochloride | |
| US4816455A (en) | Crystalline, anhydrous sigma-form of 2-(4-(2-furoyl)-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxy-quinazoline hydrochloride and a process for its preparation | |
| RU2198169C2 (ru) | Полиморфные формы 2-(3-циан-4-изобутилоксифенил)-4-метил-5-тиазолкарбоновой кислоты и способы их получения | |
| US4672133A (en) | Process for forming Form 2 ranitidine hydrochloride | |
| JP2022176979A5 (enExample) | ||
| JP4112032B2 (ja) | Ｎ−［３−（３−シアノピラゾロ［１，５−ａ］ピリミジン−７−イル）フェニル］−Ｎ−エチル−アセトアミドの改良された製造方法 | |
| JP2024514090A (ja) | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 | |
| US5306715A (en) | Rifapentine hydrohalides | |
| RU2088584C1 (ru) | Кристаллический полугидрат 4-(5,6,7,8-тетрагидроимидазо [1,5-а]пиридин-5-ил)-бензонитрил-гидрохлорида | |
| JPH08506332A (ja) | テトラゾール−５−カルボン酸誘導体の製法 | |
| TWI457342B (zh) | １１－（２－吡咯啶－１－基－乙氧基）－１４，１９－二－５，７，２６－三氮雜－四環〔１９．３．１．１（２，６）．１（８，１２）〕二十七碳－１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３－十烯順丁烯二酸鹽 | |
| IE47009B1 (en) | Improvements in or relating to benoxaprofen | |
| JPS5824569A (ja) | イミダゾ−ル誘導体の精製方法 | |
| KR900008013B1 (ko) | 흡습성이 작은 α-L-아스파르틸-L-페닐 알라닌 메틸에스테르의 제조법 | |
| HU196979B (en) | Process for producing basic thioether and salt | |
| JP2007008918A (ja) | パロキセチン塩酸塩半水和物の製造方法 | |
| JP3282047B2 (ja) | クラウン化合物の精製方法 | |
| HU194179B (en) | Process for production of 1-/3',4'-dietoxi-benzil/-1,6,7-dietoxi-3,4-dihydro-izoquinolinine-teophilin-7-acetate and their new cristallic monohydrate | |
| US5596109A (en) | N-t-butyl-androst-3,5-diene-17β-carboxamide-3-carboxylic acid polymorph A | |
| KR880001235B1 (ko) | 결정성 무수 소듐 19-데옥시아글리콘 디아네마이신의 제조 방법 | |
| JPS59176234A (ja) | ｐ‐ニトロフエニル３−ブロモ−２，２−ジエトキシ−プロピオネート | |
| JPH05230044A (ja) | ピレタニドの新規な結晶多形 | |
| Newstrom et al. | The Mercuration of Para-Cymene | |
| JP2736169B2 (ja) | Ｎ−Ｔ−ブチル−アンドロスト−３，５−ジエン−１７β−カルボキサミド−３−カルボン酸多形体Ａ | |
| US5859266A (en) | "N-T-butyl-androst-3-5-diene-17 β-carboxamide-3-carboxylic" acid polymorph A |