JPH0466456B2 - - Google Patents
Info
- Publication number
- JPH0466456B2 JPH0466456B2 JP62215366A JP21536687A JPH0466456B2 JP H0466456 B2 JPH0466456 B2 JP H0466456B2 JP 62215366 A JP62215366 A JP 62215366A JP 21536687 A JP21536687 A JP 21536687A JP H0466456 B2 JPH0466456 B2 JP H0466456B2
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- oxygen
- red blood
- blood cells
- ihp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001554 Hemoglobins Human genes 0.000 claims description 42
- 108010054147 Hemoglobins Proteins 0.000 claims description 42
- 210000003743 erythrocyte Anatomy 0.000 claims description 25
- 239000002502 liposome Substances 0.000 claims description 15
- 230000003281 allosteric effect Effects 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 5
- 238000005984 hydrogenation reaction Methods 0.000 claims description 4
- 150000003904 phospholipids Chemical class 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 39
- 239000001301 oxygen Substances 0.000 description 39
- 229910052760 oxygen Inorganic materials 0.000 description 39
- 210000004369 blood Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 11
- 150000002632 lipids Chemical class 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 239000002504 physiological saline solution Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 235000002597 Solanum melongena Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000011362 coarse particle Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- XOHUEYCVLUUEJJ-UHFFFAOYSA-N 2,3-Bisphosphoglyceric acid Chemical compound OP(=O)(O)OC(C(=O)O)COP(O)(O)=O XOHUEYCVLUUEJJ-UHFFFAOYSA-N 0.000 description 1
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- -1 phosphate compound Chemical class 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000008349 purified phosphatidyl choline Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62215366A JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62215366A JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6461426A JPS6461426A (en) | 1989-03-08 |
| JPH0466456B2 true JPH0466456B2 (fr) | 1992-10-23 |
Family
ID=16671102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62215366A Granted JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6461426A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010215517A (ja) * | 2009-03-13 | 2010-09-30 | Terumo Corp | 酸素親和性を中酸素親和性に制御したヘモグロビン含有リポソーム懸濁液 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0615747B1 (fr) * | 1993-03-18 | 1999-09-29 | Terumo Kabushiki Kaisha | Liposome encapsulant de l'hémoglobine et procédé pour sa préparation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5449314A (en) * | 1977-09-06 | 1979-04-18 | Studiengesellschaft Kohle Mbh | Improving of oxygen discharging property of erythrocyte |
| JPS5726621A (en) * | 1977-09-06 | 1982-02-12 | Studiengesellschaft Kohle Mbh | Blood containing non-injured erythropoesis having improved oxygen-release characteristica |
| JPS58183625A (ja) * | 1982-04-02 | 1983-10-26 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | 酸素運搬システム |
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| JPS62178521A (ja) * | 1986-01-30 | 1987-08-05 | Terumo Corp | ヘモグロビン含有リポソ−ム |
-
1987
- 1987-08-31 JP JP62215366A patent/JPS6461426A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5449314A (en) * | 1977-09-06 | 1979-04-18 | Studiengesellschaft Kohle Mbh | Improving of oxygen discharging property of erythrocyte |
| JPS5726621A (en) * | 1977-09-06 | 1982-02-12 | Studiengesellschaft Kohle Mbh | Blood containing non-injured erythropoesis having improved oxygen-release characteristica |
| JPS58183625A (ja) * | 1982-04-02 | 1983-10-26 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | 酸素運搬システム |
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| JPS62178521A (ja) * | 1986-01-30 | 1987-08-05 | Terumo Corp | ヘモグロビン含有リポソ−ム |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010215517A (ja) * | 2009-03-13 | 2010-09-30 | Terumo Corp | 酸素親和性を中酸素親和性に制御したヘモグロビン含有リポソーム懸濁液 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6461426A (en) | 1989-03-08 |
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