JPH0348799B2 - - Google Patents
Info
- Publication number
- JPH0348799B2 JPH0348799B2 JP60197753A JP19775385A JPH0348799B2 JP H0348799 B2 JPH0348799 B2 JP H0348799B2 JP 60197753 A JP60197753 A JP 60197753A JP 19775385 A JP19775385 A JP 19775385A JP H0348799 B2 JPH0348799 B2 JP H0348799B2
- Authority
- JP
- Japan
- Prior art keywords
- substance
- alanine
- culture
- production
- ampb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 claims description 45
- 238000004519 manufacturing process Methods 0.000 claims description 26
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 20
- 235000004279 alanine Nutrition 0.000 claims description 18
- 241000187747 Streptomyces Species 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 claims description 2
- 229960003767 alanine Drugs 0.000 description 18
- 230000000694 effects Effects 0.000 description 10
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 8
- 239000002609 medium Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000002363 herbicidal effect Effects 0.000 description 6
- 239000004009 herbicide Substances 0.000 description 6
- 239000000543 intermediate Substances 0.000 description 6
- 241000187391 Streptomyces hygroscopicus Species 0.000 description 5
- 238000012258 culturing Methods 0.000 description 5
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000001851 biosynthetic effect Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 238000012136 culture method Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229950010030 dl-alanine Drugs 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- VODITHZRQWWOME-UHFFFAOYSA-N NC(C(=O)O)(CCO)P(=O)C Chemical compound NC(C(=O)O)(CCO)P(=O)C VODITHZRQWWOME-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 239000013587 production medium Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 241001446247 uncultured actinomycete Species 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60197753A JPS6258998A (ja) | 1985-09-09 | 1985-09-09 | 含リン化合物、ｓｆ−１２９３物質の高収率製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60197753A JPS6258998A (ja) | 1985-09-09 | 1985-09-09 | 含リン化合物、ｓｆ−１２９３物質の高収率製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6258998A JPS6258998A (ja) | 1987-03-14 |
| JPH0348799B2 true JPH0348799B2 (zh) | 1991-07-25 |
Family
ID=16379769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60197753A Granted JPS6258998A (ja) | 1985-09-09 | 1985-09-09 | 含リン化合物、ｓｆ−１２９３物質の高収率製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6258998A (zh) |
-
1985
- 1985-09-09 JP JP60197753A patent/JPS6258998A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6258998A (ja) | 1987-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0249188B1 (en) | Process for the production of L-2-amino-4-(hydroxymethyl-phosphinyl)-butyric acid | |
| JPH0693839B2 (ja) | Ｌ−２−アミノ−４−（ヒドロキシメチルホスフィニル）酪酸の製造方法 | |
| KR100198039B1 (ko) | 발효에 의한 l-글루탐산의 제조방법 | |
| CA2016363A1 (en) | Method of producing trehalose | |
| EP0321849B1 (de) | Verfahren zur enzymatischen Hydrolyse von alpha-Aminoadipinyl-Monoaminoverbindungen | |
| JPH0348799B2 (zh) | ||
| JPS583678B2 (ja) | Ｌ−トリプトフアンの連続醗酵製造法 | |
| JPS5838153B2 (ja) | ハツコウホウニヨルアミノサンノセイゾウホウ | |
| US3296089A (en) | Process for the production of ribosylphosphates of 8-azapurine derivatives by fermentation | |
| US3787288A (en) | Method for preparing alpha-aminobenzylpenicillin | |
| JPS6249038B2 (zh) | ||
| CA1119981A (en) | Process for preparing 2,5-diketogluconic acid | |
| KR920005749B1 (ko) | 신균주 코리네박테리움 글루타미쿰 mwex-46 및 이를 이용한 l-아르기닌의 제조방법 | |
| KR830001258B1 (ko) | 미생물에 의한 l-글루타민의 제조방법 | |
| KR0146493B1 (ko) | 발효법에 의한 l-알라닌의 제조 방법 | |
| KR890001127B1 (ko) | 푸럭토 올리고(Fructo-oligo)당의 제조방법 | |
| JPH0367677B2 (zh) | ||
| US3616223A (en) | Penicillin intermediate | |
| KR830001259B1 (ko) | 미생물에 의한 l-글루타민의 제조방법 | |
| KR880002418B1 (ko) | 이노신 및 구아노신의 제조법 | |
| KR910007822B1 (ko) | 미생물에 의한 l-글루타민의 제조방법 | |
| JPH0561913B2 (zh) | ||
| KR800000476B1 (ko) | 미생물에 의한 아데노신의 제조법 | |
| US3617446A (en) | Preparation of 6-azauridine | |
| SU267509A1 (ru) | Способ производства /-лизина |