JPH02501826A - リポソームでカプセル化したヘモグロビンの拡大規模製造方法 - Google Patents

リポソームでカプセル化したヘモグロビンの拡大規模製造方法

Info

Publication number
JPH02501826A
JPH02501826A JP62505486A JP50548687A JPH02501826A JP H02501826 A JPH02501826 A JP H02501826A JP 62505486 A JP62505486 A JP 62505486A JP 50548687 A JP50548687 A JP 50548687A JP H02501826 A JPH02501826 A JP H02501826A
Authority
JP
Japan
Prior art keywords
hemoglobin
liposomes
lipids
encapsulated
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62505486A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0546327B2 (enExample
Inventor
ベイシンガー，リチャード・エル
ファーマー，マーサ・シー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JPH02501826A publication Critical patent/JPH02501826A/ja
Publication of JPH0546327B2 publication Critical patent/JPH0546327B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP62505486A 1986-08-29 1987-08-26 リポソームでカプセル化したヘモグロビンの拡大規模製造方法 Granted JPH02501826A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US901710 1986-08-29
US06/901,710 US4776991A (en) 1986-08-29 1986-08-29 Scaled-up production of liposome-encapsulated hemoglobin

Publications (2)

Publication Number Publication Date
JPH02501826A true JPH02501826A (ja) 1990-06-21
JPH0546327B2 JPH0546327B2 (enExample) 1993-07-13

Family

ID=25414678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62505486A Granted JPH02501826A (ja) 1986-08-29 1987-08-26 リポソームでカプセル化したヘモグロビンの拡大規模製造方法

Country Status (8)

Country Link
US (1) US4776991A (enExample)
EP (1) EP0320507B1 (enExample)
JP (1) JPH02501826A (enExample)
AT (1) ATE91411T1 (enExample)
AU (1) AU7919887A (enExample)
CA (1) CA1289072C (enExample)
DE (1) DE3786555T2 (enExample)
WO (1) WO1988001505A1 (enExample)

Families Citing this family (104)

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US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
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US5061688A (en) * 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
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Citations (3)

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US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
JPS6137735A (ja) * 1984-07-31 1986-02-22 Terumo Corp ヘモグロビン含有リポソ−ムおよびその製造方法
JPS62178521A (ja) * 1986-01-30 1987-08-05 Terumo Corp ヘモグロビン含有リポソ−ム

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JPS62178521A (ja) * 1986-01-30 1987-08-05 Terumo Corp ヘモグロビン含有リポソ−ム

Also Published As

Publication number Publication date
DE3786555D1 (de) 1993-08-19
EP0320507A1 (en) 1989-06-21
EP0320507B1 (en) 1993-07-14
WO1988001505A1 (en) 1988-03-10
US4776991A (en) 1988-10-11
AU7919887A (en) 1988-03-24
EP0320507A4 (en) 1989-04-24
DE3786555T2 (de) 1993-10-21
ATE91411T1 (de) 1993-07-15
JPH0546327B2 (enExample) 1993-07-13
CA1289072C (en) 1991-09-17

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