JPH0217557B2 - - Google Patents

Info

Publication number
JPH0217557B2
JPH0217557B2 JP54039426A JP3942679A JPH0217557B2 JP H0217557 B2 JPH0217557 B2 JP H0217557B2 JP 54039426 A JP54039426 A JP 54039426A JP 3942679 A JP3942679 A JP 3942679A JP H0217557 B2 JPH0217557 B2 JP H0217557B2
Authority
JP
Japan
Prior art keywords
formula
ester
mmol
carboxylic acid
concentrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP54039426A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54132594A (en
Inventor
Ruizu Kyandaru Robaato
Uorukaa Dereku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS54132594A publication Critical patent/JPS54132594A/ja
Publication of JPH0217557B2 publication Critical patent/JPH0217557B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP3942679A 1978-04-03 1979-04-03 Chemical method and product Granted JPS54132594A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,092 US4322347A (en) 1978-04-03 1978-04-03 2-Carbamoyloxymethyl-penicillin derivatives

Publications (2)

Publication Number Publication Date
JPS54132594A JPS54132594A (en) 1979-10-15
JPH0217557B2 true JPH0217557B2 (en:Method) 1990-04-20

Family

ID=25401020

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3942679A Granted JPS54132594A (en) 1978-04-03 1979-04-03 Chemical method and product

Country Status (15)

Country Link
US (1) US4322347A (en:Method)
JP (1) JPS54132594A (en:Method)
BE (1) BE875247A (en:Method)
CA (1) CA1140915A (en:Method)
CH (1) CH642080A5 (en:Method)
DE (1) DE2912483A1 (en:Method)
DK (1) DK129779A (en:Method)
FR (1) FR2421903B1 (en:Method)
GB (1) GB2017705B (en:Method)
IE (1) IE49046B1 (en:Method)
IT (1) IT1116851B (en:Method)
LU (1) LU81108A1 (en:Method)
NL (1) NL7902443A (en:Method)
SE (3) SE448239B (en:Method)
YU (5) YU41860B (en:Method)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374982A (en) * 1979-11-07 1983-02-22 Bristol-Myers Company Cepham compounds
IT1148888B (it) * 1980-07-15 1986-12-03 Schiena Ricerche Di Composti antibiotici
IL92139A0 (en) * 1988-10-31 1990-07-12 Hoffmann La Roche Penicillanic acid derivatives,their manufacture and pharmaceutical compositions containing them
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
CA2856179C (en) 2011-12-20 2017-02-28 F. Hoffmann-La Roche Ag 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
PT2794628T (pt) 2011-12-20 2017-07-05 Riboscience Llc Derivados nucleosídicos 4¿-azido-3¿-fluoro substituídos como inibidores de replicação de arn de vhc
MX2015015782A (es) 2013-05-16 2016-06-02 Riboscience Llc Derivados de nucleosido 4'-fluoro-2'-metil sustituido.
MX2015015781A (es) 2013-05-16 2016-06-02 Riboscience Llc Derivados de nucleósido 4'-azido, 3'-deoxi-3'-fluoro sustituido.
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275626A (en) * 1962-07-31 1966-09-27 Lilly Co Eli Penicillin conversion via sulfoxide
US3714156A (en) * 1970-06-22 1973-01-30 Univ California Lactam process
BE787618A (fr) 1971-08-17 1973-02-16 Gist Brocades Nv Procede pour preparer des composes heterocycliques
GB1425827A (en) * 1972-03-13 1976-02-18 Astra Laekemedel Ab Penicillins and cephalosporins
US4218374A (en) * 1972-10-20 1980-08-19 Fujisawa Pharmaceutical Company, Limited Penam derivatives
GB1465893A (en) * 1973-02-09 1977-03-02 Gist Brocades Nv I-carboxypropenyl-4-iminothio-azetidine-2-one derivatives methods for their preparation and use
DE2309599A1 (de) * 1973-02-26 1974-09-05 Bayer Ag Verfahren zur herstellung von 7-acylamino-desacetoxy-cephalosporansaeurederivaten
DE2320040A1 (de) 1973-04-19 1974-11-07 Bayer Ag Verfahren zur herstellung von 7acylamino-desacetoxy-cephalosporansaeureester
US4010156A (en) * 1973-04-19 1977-03-01 American Home Products Corporation Process for the rearrangement of penicillins to cephalosporins and intermediate compounds thereof
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
FR2340093A1 (fr) 1976-02-05 1977-09-02 Roussel Uclaf Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1573614A (en) * 1976-02-25 1980-08-28 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl cephalosporanates
DE2655949A1 (de) * 1976-12-10 1978-06-15 Gruenenthal Gmbh Neue cephalosporin- und penicillinderivate, verfahren zu deren herstellung und diese produkte enthaltende arzneimittel
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
CA1125745A (en) * 1978-11-20 1982-06-15 Joseph Kaspi PROCESS FOR PREPARING .beta.-LACTAM ANTIBIOTICS

Also Published As

Publication number Publication date
CA1140915A (en) 1983-02-08
NL7902443A (nl) 1979-10-05
IE49046B1 (en) 1985-07-24
IT1116851B (it) 1986-02-10
FR2421903B1 (fr) 1986-08-29
IE790947L (en) 1979-10-03
SE8402090L (sv) 1984-04-13
GB2017705A (en) 1979-10-10
LU81108A1 (de) 1979-11-07
SE458610B (sv) 1989-04-17
YU220682A (en) 1983-01-21
YU42803B (en) 1988-12-31
DK129779A (da) 1979-10-04
US4322347A (en) 1982-03-30
DE2912483A1 (de) 1979-10-11
IT7948457A0 (it) 1979-03-23
YU43096B (en) 1989-02-28
YU220582A (en) 1983-01-21
BE875247A (fr) 1979-10-01
YU42050B (en) 1988-04-30
YU220482A (en) 1983-01-21
FR2421903A1 (fr) 1979-11-02
YU220782A (en) 1983-01-21
YU75679A (en) 1983-01-21
YU41860B (en) 1988-02-29
SE8402089D0 (sv) 1984-04-13
SE8402090D0 (sv) 1984-04-13
JPS54132594A (en) 1979-10-15
SE8402089L (sv) 1984-04-13
YU42802B (en) 1988-12-31
GB2017705B (en) 1982-10-27
SE458609B (sv) 1989-04-17
CH642080A5 (fr) 1984-03-30
SE7902916L (sv) 1979-10-04
SE448239B (sv) 1987-02-02

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