JPH0137118B2 - - Google Patents
Info
- Publication number
- JPH0137118B2 JPH0137118B2 JP55064449A JP6444980A JPH0137118B2 JP H0137118 B2 JPH0137118 B2 JP H0137118B2 JP 55064449 A JP55064449 A JP 55064449A JP 6444980 A JP6444980 A JP 6444980A JP H0137118 B2 JPH0137118 B2 JP H0137118B2
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- enzyme
- activity
- freeze
- dihydrofluorate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010088751 Albumins Proteins 0.000 claims description 15
- 102000009027 Albumins Human genes 0.000 claims description 15
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 description 17
- 108090000790 Enzymes Proteins 0.000 description 17
- 230000000694 effects Effects 0.000 description 17
- 229940088598 enzyme Drugs 0.000 description 17
- 230000007423 decrease Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000011481 absorbance measurement Methods 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003432 anti-folate effect Effects 0.000 description 1
- 229940127074 antifolate Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 239000004052 folic acid antagonist Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6444980A JPS56160991A (en) | 1980-05-15 | 1980-05-15 | Stabilized dihydrofolate reductase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6444980A JPS56160991A (en) | 1980-05-15 | 1980-05-15 | Stabilized dihydrofolate reductase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56160991A JPS56160991A (en) | 1981-12-11 |
| JPH0137118B2 true JPH0137118B2 (enExample) | 1989-08-04 |
Family
ID=13258566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6444980A Granted JPS56160991A (en) | 1980-05-15 | 1980-05-15 | Stabilized dihydrofolate reductase |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56160991A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2575648B2 (ja) * | 1986-04-24 | 1997-01-29 | 国際試薬株式会社 | クレアチンキナ−ゼの安定化方法 |
| US5523223A (en) * | 1992-03-13 | 1996-06-04 | Forschungszentrum Julich Gmbh | Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters |
| CN111295094A (zh) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | 冻干容器及使用冻干容器的方法 |
| WO2020242552A1 (en) | 2019-03-14 | 2020-12-03 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
-
1980
- 1980-05-15 JP JP6444980A patent/JPS56160991A/ja active Granted
Non-Patent Citations (1)
| Title |
|---|
| CLIN CHEM=1980 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56160991A (en) | 1981-12-11 |
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