JPH0131485B2 - - Google Patents
Info
- Publication number
- JPH0131485B2 JPH0131485B2 JP56115817A JP11581781A JPH0131485B2 JP H0131485 B2 JPH0131485 B2 JP H0131485B2 JP 56115817 A JP56115817 A JP 56115817A JP 11581781 A JP11581781 A JP 11581781A JP H0131485 B2 JPH0131485 B2 JP H0131485B2
- Authority
- JP
- Japan
- Prior art keywords
- miconazole
- gel
- peppermint oil
- cream
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000006071 cream Substances 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 28
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 25
- 235000019477 peppermint oil Nutrition 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 19
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 18
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 claims description 12
- 229960003338 crotamiton Drugs 0.000 claims description 12
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 12
- 229940121375 antifungal agent Drugs 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 229960001047 methyl salicylate Drugs 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 7
- 230000000843 anti-fungal effect Effects 0.000 claims description 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 6
- 229960004889 salicylic acid Drugs 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical class ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 54
- 229960002509 miconazole Drugs 0.000 description 53
- 239000000499 gel Substances 0.000 description 30
- 239000000243 solution Substances 0.000 description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000000203 mixture Substances 0.000 description 13
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 12
- 239000008213 purified water Substances 0.000 description 12
- 238000009472 formulation Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 229920002125 Sokalan® Polymers 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 6
- 229940057995 liquid paraffin Drugs 0.000 description 6
- 239000003429 antifungal agent Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000001139 anti-pruritic effect Effects 0.000 description 4
- 235000019445 benzyl alcohol Nutrition 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 4
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 description 3
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- 229960003913 econazole Drugs 0.000 description 3
- 229960004849 isoconazole Drugs 0.000 description 3
- 230000007721 medicinal effect Effects 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 235000011076 sorbitan monostearate Nutrition 0.000 description 3
- 239000001587 sorbitan monostearate Substances 0.000 description 3
- 229940035048 sorbitan monostearate Drugs 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000003871 white petrolatum Substances 0.000 description 3
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
- 229920002884 Laureth 4 Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229960004022 clotrimazole Drugs 0.000 description 2
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- -1 2-chlorphenyl Chemical group 0.000 description 1
- HCJMNOSIAGSZBM-UHFFFAOYSA-N 6-methylsalicylic acid Chemical compound CC1=CC=CC(O)=C1C(O)=O HCJMNOSIAGSZBM-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 230000000240 adjuvant effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000008311 hydrophilic ointment Substances 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56115817A JPS5815909A (ja) | 1981-07-22 | 1981-07-22 | 抗真菌外用剤 |
| EP82106376A EP0070525B1 (en) | 1981-07-22 | 1982-07-15 | Fungicidal preparations for external use |
| DE8282106376T DE3275059D1 (en) | 1981-07-22 | 1982-07-15 | Fungicidal preparations for external use |
| DK328082A DK158930C (da) | 1981-07-22 | 1982-07-21 | Fremgangsmaade til fremstilling af antifungalt farmaceutisk praeparat til ekstern anvendelse |
| ES514214A ES514214A0 (es) | 1981-07-22 | 1982-07-21 | Un preparado farmaceutico. |
| CA000407775A CA1174601A (en) | 1981-07-22 | 1982-07-21 | Pharmaceutical preparations for external use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56115817A JPS5815909A (ja) | 1981-07-22 | 1981-07-22 | 抗真菌外用剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5815909A JPS5815909A (ja) | 1983-01-29 |
| JPH0131485B2 true JPH0131485B2 (da) | 1989-06-26 |
Family
ID=14671831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56115817A Granted JPS5815909A (ja) | 1981-07-22 | 1981-07-22 | 抗真菌外用剤 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0070525B1 (da) |
| JP (1) | JPS5815909A (da) |
| CA (1) | CA1174601A (da) |
| DE (1) | DE3275059D1 (da) |
| DK (1) | DK158930C (da) |
| ES (1) | ES514214A0 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3244027A1 (de) * | 1982-11-27 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von gelsystemen |
| JPS6058914A (ja) * | 1983-09-12 | 1985-04-05 | Shionogi & Co Ltd | イミダゾ−ル系抗真菌性外用ゲル製剤 |
| US4912124A (en) * | 1984-02-23 | 1990-03-27 | Ortho Pharmaceutical Corporation | Antifungal dermatological solution |
| CS253719B2 (en) * | 1984-03-07 | 1987-12-17 | Janssen Pharmaceutica Nv | Emulsible concentrate with fungicide activity and process for preparing thereof |
| US4820724A (en) * | 1986-03-31 | 1989-04-11 | University Of Southern California | Dual phase solvent carrier system |
| HU200914B (en) * | 1987-03-09 | 1990-09-28 | Horvath Gyoengyi Lengyelne | Process for producing new medical dosage unit suitable for local treatment of fungus infection of nails |
| GB2208598A (en) * | 1987-08-15 | 1989-04-12 | Ciba Geigy Ag | Antimicrobial preparations for external use |
| GB8921710D0 (en) * | 1989-09-26 | 1989-11-08 | Mentholatum Co Ltd | Ibuprofen triturates and topical compositions containing same |
| US5240932A (en) * | 1990-03-30 | 1993-08-31 | Yasunori Morimoto | Percutaneously absorbable compositions of morphine or analogous analgesics of morphine |
| JPH07179341A (ja) * | 1993-12-22 | 1995-07-18 | Toko Yakuhin Kogyo Kk | 安定なミコフェノール酸含有皮膚外用剤 |
| JP3081766B2 (ja) * | 1994-05-06 | 2000-08-28 | 東興薬品工業株式会社 | 角質貯留型抗真菌外用組成物 |
| FR2721515B1 (fr) * | 1994-06-28 | 1996-09-13 | Fabre Pierre Cosmetique | Composition pharmaceutique antibactérienne. |
| FR2722689B1 (fr) * | 1994-07-20 | 1996-10-04 | Fabre Pierre Dermo Cosmetique | Nouveau produit de combinaison comprenant un agent antifongique et du crotamiton comme potentialisateur de l'activite de l'agent antifongique, et compositions dermatologiques et/ou cosmetiques le comprenant |
| FR2728791B1 (fr) * | 1995-01-03 | 1997-03-21 | Fabre Pierre Dermo Cosmetique | Produit antifongique contenant du crotamiton, composition antifongique et utilisation a titre de medicament |
| CA2479381C (en) * | 2002-03-25 | 2011-11-01 | Council Of Scientific And Industrial Research | A use of treatment for fungal infections with a synergistic formulation of antifungal agent, menthol and menthyl acetate |
| WO2005082334A1 (ja) * | 2004-02-27 | 2005-09-09 | Hisamitsu Pharmaceutical Co., Inc. | 徐放性クリーム剤 |
| US7597913B2 (en) * | 2004-10-04 | 2009-10-06 | Marc Selner | Penetrating carrier, anti-fungal composition using the same and method for treatment of dermatophytes |
| EP2025337B1 (en) | 2006-03-08 | 2014-09-10 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
| CA2645070C (en) | 2006-03-08 | 2014-02-04 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
| CN101808637B (zh) | 2007-09-05 | 2013-07-24 | 宝丽制药股份有限公司 | 医药组合物 |
| KR20100075476A (ko) | 2007-09-05 | 2010-07-02 | 가부시키가이샤 폴라 파마 | 항진균 조성물 |
| JP5453093B2 (ja) | 2007-09-05 | 2014-03-26 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
| JP5743375B2 (ja) * | 2008-09-30 | 2015-07-01 | 小林製薬株式会社 | カンジダ症予防又は治療剤 |
| EP2416757A2 (en) * | 2009-04-09 | 2012-02-15 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| KR101409792B1 (ko) | 2009-04-09 | 2014-06-19 | 니혼노야쿠가부시키가이샤 | 항진균성 약제학적 조성물 |
| KR101754697B1 (ko) | 2009-08-25 | 2017-07-06 | 가부시키가이샤 폴라 파마 | 항진균성 약제학적 조성물 |
| CN113648278A (zh) * | 2013-05-03 | 2021-11-16 | 立普妥公司 | 用于给药的运载体和局部组合物 |
| CN111358751B (zh) * | 2018-12-25 | 2023-04-18 | 沈阳兴齐眼药股份有限公司 | 眼用药物组合物、眼用药盒及其医药用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5039664A (da) * | 1973-08-15 | 1975-04-11 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB925407A (en) * | 1960-08-02 | 1963-05-08 | Geigy Ag J R | Dermatological preparations containing corticosteroids |
| SU557755A3 (ru) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Способ получени производных имидазола |
| US4123542A (en) * | 1977-01-19 | 1978-10-31 | Syntex (U.S.A.) Inc. | Derivatives of N-alkyl imidazoles |
| US4267169A (en) * | 1978-07-22 | 1981-05-12 | Toko Yakuhin Kogyo Kabushiki Kaisha | Novel preparation of clotrimazole |
| DE2851116A1 (de) * | 1978-11-25 | 1980-06-12 | Bayer Ag | Hydroxyethyl-azole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2918897A1 (de) * | 1979-05-10 | 1980-11-20 | Bayer Ag | Antimikrobielle mittel |
| DE2928968A1 (de) * | 1979-07-18 | 1981-02-12 | Bayer Ag | Antimikrobielle mittel |
| DE2931778A1 (de) * | 1979-08-04 | 1981-02-19 | Bayer Ag | Antimikrobielle mittel |
| DE2946957A1 (de) * | 1979-11-21 | 1981-06-04 | Bayer Ag, 5090 Leverkusen | Antimikrobielle mittel |
| GB2068228B (en) * | 1980-01-24 | 1984-02-29 | Janssen Pharmaceutica Nv | Anti-microbial compositions for the topical treatment of acne vulgaris |
| DE3030323A1 (de) * | 1980-08-11 | 1982-03-11 | Syntex (U.S.A.) Inc., 94304 Palo Alto, Calif. | Die verwendung von imidazolderivaten als spermatostatika oder spermizide |
-
1981
- 1981-07-22 JP JP56115817A patent/JPS5815909A/ja active Granted
-
1982
- 1982-07-15 EP EP82106376A patent/EP0070525B1/en not_active Expired
- 1982-07-15 DE DE8282106376T patent/DE3275059D1/de not_active Expired
- 1982-07-21 ES ES514214A patent/ES514214A0/es active Granted
- 1982-07-21 DK DK328082A patent/DK158930C/da not_active IP Right Cessation
- 1982-07-21 CA CA000407775A patent/CA1174601A/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5039664A (da) * | 1973-08-15 | 1975-04-11 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK158930C (da) | 1991-01-21 |
| EP0070525A2 (en) | 1983-01-26 |
| CA1174601A (en) | 1984-09-18 |
| ES8401850A1 (es) | 1984-01-01 |
| EP0070525A3 (en) | 1984-01-11 |
| DK328082A (da) | 1983-01-23 |
| DE3275059D1 (en) | 1987-02-19 |
| ES514214A0 (es) | 1984-01-01 |
| EP0070525B1 (en) | 1987-01-14 |
| DK158930B (da) | 1990-08-06 |
| JPS5815909A (ja) | 1983-01-29 |
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