JPH0114898B2 - - Google Patents

Info

Publication number
JPH0114898B2
JPH0114898B2 JP59119735A JP11973584A JPH0114898B2 JP H0114898 B2 JPH0114898 B2 JP H0114898B2 JP 59119735 A JP59119735 A JP 59119735A JP 11973584 A JP11973584 A JP 11973584A JP H0114898 B2 JPH0114898 B2 JP H0114898B2
Authority
JP
Japan
Prior art keywords
formula
acid
group
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP59119735A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6025953A (ja
Inventor
Guriru Herumyuto
Raiteru Furiidoman
Roozaru Roorando
Shuriatsuku Mikaeru
Zaiberu Kurausu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of JPS6025953A publication Critical patent/JPS6025953A/ja
Publication of JPH0114898B2 publication Critical patent/JPH0114898B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP59119735A 1983-07-20 1984-06-11 ｐ−オキシ安息香酸誘導体、その製造方法および過脂肪血症治療剤 Granted JPS6025953A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3326164A DE3326164A1 (de) 1983-07-20 1983-07-20 Neue p-oxibenzoesaeure-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3326164.4 1983-07-20

Publications (2)

Publication Number Publication Date
JPS6025953A JPS6025953A (ja) 1985-02-08
JPH0114898B2 true JPH0114898B2 (en, 2012) 1989-03-14

Family

ID=6204458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59119735A Granted JPS6025953A (ja) 1983-07-20 1984-06-11 ｐ−オキシ安息香酸誘導体、その製造方法および過脂肪血症治療剤

Country Status (9)

Country Link
US (1) US4582857B1 (en, 2012)
EP (1) EP0133935B1 (en, 2012)
JP (1) JPS6025953A (en, 2012)
AT (1) ATE31527T1 (en, 2012)
AU (1) AU560643B2 (en, 2012)
CA (1) CA1214784A (en, 2012)
DE (2) DE3326164A1 (en, 2012)
IE (1) IE57702B1 (en, 2012)
MX (1) MX9203752A (en, 2012)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717736A (en) * 1984-01-23 1988-01-05 Merck Frosst Canada, Inc. Antagonists of slow reacting substances of anaphylaxis
US4778925A (en) * 1985-12-30 1988-10-18 Klinge Pharma Gmbh New benzoic acid derivatives, as well as processes for their production and their use as pharmaceuticals
AU601739B2 (en) * 1987-05-19 1990-09-20 Klinge Pharma Gmbh Para-substituted benzoic acid derivatives and methods of manufacture
DE3903988A1 (de) * 1989-02-10 1990-08-30 Basf Ag Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
DE4032037A1 (de) * 1990-10-09 1992-04-16 Klinge Co Chem Pharm Fab Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4119055A1 (de) * 1991-06-10 1992-12-17 Klinge Co Chem Pharm Fab Verfahren zur herstellung der reinen enantiomere des lifibrol und seiner alkylester
DE4127800A1 (de) * 1991-08-22 1993-02-25 Klinge Co Chem Pharm Fab Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4314175C2 (de) * 1993-04-29 1995-03-30 Klinge Co Chem Pharm Fab Modifikation II von Lifibrol
DE4414538A1 (de) * 1994-04-26 1995-11-02 Klinge Co Chem Pharm Fab Präparate zur Therapie der kombinierten Hyperlipidämie mit einem Gehalt an einem p-Oxybenzoesäurederivat und einem Fibrat
DE4414537A1 (de) * 1994-04-26 1995-11-02 Klinge Co Chem Pharm Fab Kombinationspräparate mit einem Gehalt an einem p-Oxybenzoesäurederivat und einem HMG-CoA-Reduktase-Hemmer
GB9417532D0 (en) * 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE689347A (en, 2012) * 1965-12-09 1967-04-14 Madan Ag
BE795722A (fr) * 1972-02-24 1973-06-18 Fabre Sa Pierre Nouveaux derives a activite anti-inflammatoire et antalgique
DE2342118C2 (de) * 1973-08-21 1982-09-23 Merck Patent Gmbh, 6100 Darmstadt Phenoxypropionsäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US4098816A (en) * 1973-08-23 1978-07-04 Beecham Group Limited Polycyclic oxy-aromatic acid
DE2460689C3 (de) * 1974-12-20 1980-06-26 Klinge Pharma Gmbh & Co, 8000 Muenchen 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US4151302A (en) * 1975-06-28 1979-04-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Araliphatic dihalogen compounds composition and method of use
GB1551416A (en) * 1976-08-27 1979-08-30 Beecham Group Ltd Long chain dioxy hypolipidaemics
DE2735856A1 (de) * 1977-08-09 1979-02-22 Klinge Co Chem Pharm Fab Neue 1,3-diphenoxypropan-2-on-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2420522A1 (fr) * 1978-03-20 1979-10-19 Unicler Derives de l'acide (m-benzoyl-phenoxy)-2 propionique et leurs applications comme medicaments
EP0056172B1 (en) * 1981-01-09 1985-04-03 FISONS plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them

Also Published As

Publication number Publication date
EP0133935B1 (de) 1987-12-23
US4582857B1 (en) 1994-02-15
IE57702B1 (en) 1993-03-10
EP0133935A3 (en) 1985-05-15
AU560643B2 (en) 1987-04-09
DE3468209D1 (en) 1988-02-04
DE3326164A1 (de) 1985-01-31
US4582857A (en) 1986-04-15
AU2985184A (en) 1985-01-24
JPS6025953A (ja) 1985-02-08
MX9203752A (es) 1992-09-01
EP0133935A2 (de) 1985-03-13
ATE31527T1 (de) 1988-01-15
IE841866L (en) 1985-01-20
CA1214784A (en) 1986-12-02

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