JP7837335B2 - 鎮痛効果を誘導するためのジカルボン酸エステル - Google Patents

鎮痛効果を誘導するためのジカルボン酸エステル

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Publication number
JP7837335B2
JP7837335B2 JP2023536038A JP2023536038A JP7837335B2 JP 7837335 B2 JP7837335 B2 JP 7837335B2 JP 2023536038 A JP2023536038 A JP 2023536038A JP 2023536038 A JP2023536038 A JP 2023536038A JP 7837335 B2 JP7837335 B2 JP 7837335B2
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JP
Japan
Prior art keywords
pain
weight
dicarboxylic acid
dea
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023536038A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023553642A5 (enExample
JP2023553642A (ja
Inventor
ロバート ティー． ストリーパー，
エルズビエタ イズビツカ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New Frontier Labs LLC
Original Assignee
New Frontier Labs LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Frontier Labs LLC filed Critical New Frontier Labs LLC
Publication of JP2023553642A publication Critical patent/JP2023553642A/ja
Publication of JP2023553642A5 publication Critical patent/JP2023553642A5/ja
Application granted granted Critical
Publication of JP7837335B2 publication Critical patent/JP7837335B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023536038A 2020-12-16 2021-12-16 鎮痛効果を誘導するためのジカルボン酸エステル Active JP7837335B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063126387P 2020-12-16 2020-12-16
US63/126,387 2020-12-16
PCT/IB2021/061872 WO2022130288A1 (en) 2020-12-16 2021-12-16 Dicarboxylic acid esters for inducing an analgesic effect

Publications (3)

Publication Number Publication Date
JP2023553642A JP2023553642A (ja) 2023-12-25
JP2023553642A5 JP2023553642A5 (enExample) 2024-10-28
JP7837335B2 true JP7837335B2 (ja) 2026-03-30

Family

ID=81942874

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023536038A Active JP7837335B2 (ja) 2020-12-16 2021-12-16 鎮痛効果を誘導するためのジカルボン酸エステル

Country Status (12)

Country Link
US (1) US11911358B2 (enExample)
EP (1) EP4262779A4 (enExample)
JP (1) JP7837335B2 (enExample)
KR (1) KR20230131182A (enExample)
CN (1) CN116829141A (enExample)
AU (1) AU2021400215A1 (enExample)
CA (1) CA3202461A1 (enExample)
CL (1) CL2023001737A1 (enExample)
CO (1) CO2023007903A2 (enExample)
IL (1) IL303751A (enExample)
MX (1) MX2023006728A (enExample)
WO (1) WO2022130288A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022022437A2 (pt) 2020-05-07 2023-01-03 Adorx Therapeutics Ltd Antagonistas do receptor a2a de adenosina
US20260048034A1 (en) 2024-08-15 2026-02-19 New Frontier Labs, Llc Compositions and methods for enhancing the efficacy of dicarboxylic acid esters, and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015514768A (ja) 2012-04-18 2015-05-21 ストリーパー, ロバート, ティー.STREEPER, Robert, T. 生体分子によって媒介されるコミュニケーションをアゼライン酸エステルを用いて調節する方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
JPH07116026B2 (ja) * 1987-07-07 1995-12-13 株式会社資生堂 ジクロフェナックナトリウム含有乳化外用剤
JP2523428B2 (ja) * 1992-12-04 1996-08-07 エスエス製薬株式会社 消炎鎮痛ゲル製剤
US9265725B2 (en) * 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
JP2004300113A (ja) * 2003-04-01 2004-10-28 Nichiban Co Ltd 消炎鎮痛貼付剤
WO2006074379A2 (en) * 2005-01-07 2006-07-13 Azaya Therapeutics, Inc. Methods and compositions involving esters of azelaic acid and other dicarboxylic acids
US8822509B2 (en) * 2006-12-29 2014-09-02 The University Of Queensland Pain-relieving compositions and uses therefor
EP2219633A2 (en) * 2007-11-23 2010-08-25 Nectid, Inc. Tapentadol compositions
US20090326069A1 (en) * 2008-06-30 2009-12-31 Bltn, Llc Azelaic acid ester compositions and methods for diagnosing and treating tissue conditions using azelaic acid ester compositions and proteinaceous biomarkers
BRPI0901758A2 (pt) * 2009-05-28 2011-01-25 Cristalia Prod Quimicos Farm uso de telocinobufagina como analgésico no tratamento das dores aguda e crÈnica; composição farmacêutica contendo telocinobufagina e uso da mesma
EP3445354B8 (en) * 2016-04-20 2022-07-06 New Frontier Labs, LLC Azelaic acid esters in the treatment of insulin resistance
US20220023423A1 (en) * 2018-12-19 2022-01-27 Medrx Co., Ltd. Anti-Inflammatory Analgesic External Preparation
CN111544381B (zh) * 2020-05-12 2021-07-16 普霖贝利生物医药研发(上海)有限公司 一种包含壬二酸的皮肤局部给药组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015514768A (ja) 2012-04-18 2015-05-21 ストリーパー, ロバート, ティー.STREEPER, Robert, T. 生体分子によって媒介されるコミュニケーションをアゼライン酸エステルを用いて調節する方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cell. Mol. Life Sci.，2007年，Vol.64，pp.1128-1136
in vivo，2021年，Vol.35，pp.3073-3095
J. Exp. Med.，2018年，Vol.215, No.12，pp.3019-3037

Also Published As

Publication number Publication date
AU2021400215A9 (en) 2025-03-20
CN116829141A (zh) 2023-09-29
MX2023006728A (es) 2023-06-19
WO2022130288A1 (en) 2022-06-23
KR20230131182A (ko) 2023-09-12
EP4262779A4 (en) 2024-11-13
US11911358B2 (en) 2024-02-27
CA3202461A1 (en) 2022-06-23
AU2021400215A1 (en) 2023-07-06
US20220184023A1 (en) 2022-06-16
IL303751A (en) 2023-08-01
CO2023007903A2 (es) 2023-06-30
CL2023001737A1 (es) 2024-01-19
JP2023553642A (ja) 2023-12-25
EP4262779A1 (en) 2023-10-25

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