JP7824281B2 - ガストリン放出ペプチド受容体アンタゴニストを含むコンジュゲートまたはその塩およびそれらの使用 - Google Patents
ガストリン放出ペプチド受容体アンタゴニストを含むコンジュゲートまたはその塩およびそれらの使用Info
- Publication number
- JP7824281B2 JP7824281B2 JP2023518426A JP2023518426A JP7824281B2 JP 7824281 B2 JP7824281 B2 JP 7824281B2 JP 2023518426 A JP2023518426 A JP 2023518426A JP 2023518426 A JP2023518426 A JP 2023518426A JP 7824281 B2 JP7824281 B2 JP 7824281B2
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- mice
- radionuclide
- dose
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20306109.8A EP3973999A1 (en) | 2020-09-28 | 2020-09-28 | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| EP20306109.8 | 2020-09-28 | ||
| PCT/EP2021/076107 WO2022063850A1 (en) | 2020-09-28 | 2021-09-22 | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023542218A JP2023542218A (ja) | 2023-10-05 |
| JP2023542218A5 JP2023542218A5 (enExample) | 2024-07-09 |
| JP7824281B2 true JP7824281B2 (ja) | 2026-03-04 |
Family
ID=74180915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023518426A Active JP7824281B2 (ja) | 2020-09-28 | 2021-09-22 | ガストリン放出ペプチド受容体アンタゴニストを含むコンジュゲートまたはその塩およびそれらの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20230372552A1 (enExample) |
| EP (2) | EP3973999A1 (enExample) |
| JP (1) | JP7824281B2 (enExample) |
| KR (1) | KR20230078690A (enExample) |
| CN (1) | CN116322798A (enExample) |
| AU (1) | AU2021348219A1 (enExample) |
| BR (1) | BR112023003690A2 (enExample) |
| CA (1) | CA3189680A1 (enExample) |
| DK (1) | DK4188457T3 (enExample) |
| ES (1) | ES2989009T3 (enExample) |
| FI (1) | FI4188457T3 (enExample) |
| HR (1) | HRP20241285T1 (enExample) |
| HU (1) | HUE068360T2 (enExample) |
| IL (1) | IL300486A (enExample) |
| LT (1) | LT4188457T (enExample) |
| PL (1) | PL4188457T3 (enExample) |
| PT (1) | PT4188457T (enExample) |
| RS (1) | RS65994B1 (enExample) |
| SI (1) | SI4188457T1 (enExample) |
| SM (1) | SMT202400392T1 (enExample) |
| WO (1) | WO2022063850A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025163083A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150217006A1 (en) | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| JP2020505445A (ja) | 2017-01-12 | 2020-02-20 | ラジオメディックス インコーポレイテッド | 放射性同位体にキレートされたオクトレオチド誘導体を用いるソマトスタチン受容体を過剰発現しているがん細胞の治療 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2100900A1 (en) | 2008-03-07 | 2009-09-16 | Universitätsspital Basel | Bombesin analog peptide antagonist conjugates |
-
2020
- 2020-09-28 EP EP20306109.8A patent/EP3973999A1/en not_active Withdrawn
-
2021
- 2021-09-22 WO PCT/EP2021/076107 patent/WO2022063850A1/en not_active Ceased
- 2021-09-22 EP EP21778502.1A patent/EP4188457B1/en active Active
- 2021-09-22 RS RS20241053A patent/RS65994B1/sr unknown
- 2021-09-22 PL PL21778502.1T patent/PL4188457T3/pl unknown
- 2021-09-22 JP JP2023518426A patent/JP7824281B2/ja active Active
- 2021-09-22 KR KR1020237011366A patent/KR20230078690A/ko active Pending
- 2021-09-22 FI FIEP21778502.1T patent/FI4188457T3/fi active
- 2021-09-22 CA CA3189680A patent/CA3189680A1/en active Pending
- 2021-09-22 PT PT217785021T patent/PT4188457T/pt unknown
- 2021-09-22 SM SM20240392T patent/SMT202400392T1/it unknown
- 2021-09-22 BR BR112023003690A patent/BR112023003690A2/pt unknown
- 2021-09-22 ES ES21778502T patent/ES2989009T3/es active Active
- 2021-09-22 LT LTEPPCT/EP2021/076107T patent/LT4188457T/lt unknown
- 2021-09-22 SI SI202130186T patent/SI4188457T1/sl unknown
- 2021-09-22 HU HUE21778502A patent/HUE068360T2/hu unknown
- 2021-09-22 US US18/246,706 patent/US20230372552A1/en active Pending
- 2021-09-22 IL IL300486A patent/IL300486A/en unknown
- 2021-09-22 AU AU2021348219A patent/AU2021348219A1/en active Pending
- 2021-09-22 HR HRP20241285TT patent/HRP20241285T1/hr unknown
- 2021-09-22 DK DK21778502.1T patent/DK4188457T3/da active
- 2021-09-22 CN CN202180065166.XA patent/CN116322798A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150217006A1 (en) | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| JP2020505445A (ja) | 2017-01-12 | 2020-02-20 | ラジオメディックス インコーポレイテッド | 放射性同位体にキレートされたオクトレオチド誘導体を用いるソマトスタチン受容体を過剰発現しているがん細胞の治療 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021348219A1 (en) | 2023-03-09 |
| KR20230078690A (ko) | 2023-06-02 |
| SI4188457T1 (sl) | 2025-01-31 |
| LT4188457T (lt) | 2024-12-27 |
| SMT202400392T1 (it) | 2024-11-15 |
| PT4188457T (pt) | 2024-09-10 |
| CN116322798A (zh) | 2023-06-23 |
| WO2022063850A1 (en) | 2022-03-31 |
| DK4188457T3 (da) | 2024-08-26 |
| US20230372552A1 (en) | 2023-11-23 |
| FI4188457T3 (fi) | 2024-09-23 |
| HRP20241285T1 (hr) | 2025-01-03 |
| RS65994B1 (sr) | 2024-10-31 |
| PL4188457T3 (pl) | 2025-01-07 |
| EP3973999A1 (en) | 2022-03-30 |
| BR112023003690A2 (pt) | 2023-04-04 |
| ES2989009T3 (es) | 2024-11-25 |
| IL300486A (en) | 2023-04-01 |
| EP4188457A1 (en) | 2023-06-07 |
| HUE068360T2 (hu) | 2024-12-28 |
| JP2023542218A (ja) | 2023-10-05 |
| CA3189680A1 (en) | 2022-03-31 |
| EP4188457B1 (en) | 2024-07-03 |
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