JP7780857B2 - 抗ｐｄ－１抗体を用いる腫瘍の治療方法 - Google Patents

抗ｐｄ－１抗体を用いる腫瘍の治療方法

Info

Publication number
JP7780857B2
JP7780857B2 JP2019566619A JP2019566619A JP7780857B2 JP 7780857 B2 JP7780857 B2 JP 7780857B2 JP 2019566619 A JP2019566619 A JP 2019566619A JP 2019566619 A JP2019566619 A JP 2019566619A JP 7780857 B2 JP7780857 B2 JP 7780857B2
Authority
JP
Japan
Prior art keywords
antibody
tumor
subject
mutation
stk11
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019566619A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020522508A (ja
JP2020522508A5 (enExample
Inventor
ロビン・エドワーズ
ウィリアム・ジェイ・ギース
ダニエル・エム・グリーナウォルト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2020522508A publication Critical patent/JP2020522508A/ja
Publication of JP2020522508A5 publication Critical patent/JP2020522508A5/ja
Priority to JP2023127759A priority Critical patent/JP2023159179A/ja
Application granted granted Critical
Publication of JP7780857B2 publication Critical patent/JP7780857B2/ja
Priority to JP2025281525A priority patent/JP2026053613A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019566619A 2017-06-01 2018-06-01 抗ｐｄ－１抗体を用いる腫瘍の治療方法 Active JP7780857B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023127759A JP2023159179A (ja) 2017-06-01 2023-08-04 抗ｐｄ－１抗体を用いる腫瘍の治療方法
JP2025281525A JP2026053613A (ja) 2017-06-01 2025-12-25 抗ｐｄ－１抗体を用いる腫瘍の治療方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513831P 2017-06-01 2017-06-01
US62/513,831 2017-06-01
PCT/US2018/035670 WO2018223040A1 (en) 2017-06-01 2018-06-01 Methods of treating a tumor using an anti-pd-1 antibody

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023127759A Division JP2023159179A (ja) 2017-06-01 2023-08-04 抗ｐｄ－１抗体を用いる腫瘍の治療方法

Publications (3)

Publication Number Publication Date
JP2020522508A JP2020522508A (ja) 2020-07-30
JP2020522508A5 JP2020522508A5 (enExample) 2021-07-26
JP7780857B2 true JP7780857B2 (ja) 2025-12-05

Family

ID=62685228

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019566619A Active JP7780857B2 (ja) 2017-06-01 2018-06-01 抗ｐｄ－１抗体を用いる腫瘍の治療方法
JP2023127759A Pending JP2023159179A (ja) 2017-06-01 2023-08-04 抗ｐｄ－１抗体を用いる腫瘍の治療方法
JP2025281525A Pending JP2026053613A (ja) 2017-06-01 2025-12-25 抗ｐｄ－１抗体を用いる腫瘍の治療方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023127759A Pending JP2023159179A (ja) 2017-06-01 2023-08-04 抗ｐｄ－１抗体を用いる腫瘍の治療方法
JP2025281525A Pending JP2026053613A (ja) 2017-06-01 2025-12-25 抗ｐｄ－１抗体を用いる腫瘍の治療方法

Country Status (6)

Country Link
US (3) US11566073B2 (enExample)
EP (1) EP3630840A1 (enExample)
JP (3) JP7780857B2 (enExample)
KR (2) KR20240149982A (enExample)
CN (2) CN110678483B (enExample)
WO (1) WO2018223040A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013263076B2 (en) 2012-05-15 2017-08-31 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
WO2016176504A1 (en) 2015-04-28 2016-11-03 Bristol-Myers Squibb Company Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody
JP2018514550A (ja) 2015-04-28 2018-06-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｐｄ−１抗体および抗ｃｔｌａ−４抗体を使用するｐｄ−ｌ１陰性黒色腫の処置
MX392711B (es) 2015-08-11 2025-03-24 Wuxi Biologics Ireland Ltd Anticuerpos anti-pd-1 novedosos.
JP7780857B2 (ja) 2017-06-01 2025-12-05 ブリストル－マイヤーズ スクイブ カンパニー 抗ｐｄ－１抗体を用いる腫瘍の治療方法
JP2021513541A (ja) * 2018-02-13 2021-05-27 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗ｐｄ−１抗体によるがんの処置方法
CN111821434A (zh) * 2019-04-17 2020-10-27 上海君实生物医药科技股份有限公司 抗pd-1抗体在制备治疗实体瘤的药物中的用途
JP2022514952A (ja) * 2018-12-19 2022-02-16 ストラータ オンコロジー， インコーポレイテッド チェックポイント阻害薬応答性がんを有する対象を検出及び処置する方法
KR20220004744A (ko) * 2019-05-03 2022-01-11 제넨테크, 인크. 항-pd-l1 항체를 이용하여 암을 치료하는 방법
US12275986B2 (en) * 2020-01-06 2025-04-15 Duke University Biomarkers associated with checkpoint immune therapy and methods of using same
CN110923329B (zh) * 2020-02-06 2020-05-12 至本医疗科技（上海）有限公司 Fgfr4点突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
CN111440822A (zh) * 2020-04-16 2020-07-24 苏州大学附属第二医院 一种突变lats1质粒的构建与应用
US20240101666A1 (en) 2020-10-23 2024-03-28 Bristol-Myers Squibb Company Lag-3 antagonist therapy for lung cancer
CN112961920A (zh) * 2021-03-24 2021-06-15 臻和(北京)生物科技有限公司 一种预测肝胆肿瘤患者免疫检查点抑制剂联合靶向治疗疗效的方法及产品
JP7806990B2 (ja) * 2021-08-10 2026-01-27 国立大学法人 新潟大学 内胚葉嚢胞の悪性化に関連する遺伝子の検出方法
CN113943806A (zh) * 2021-11-04 2022-01-18 至本医疗科技（上海）有限公司 预测肺腺癌患者对免疫疗法敏感性的生物标志物、应用和装置
EP4515000B1 (en) * 2022-04-26 2026-04-01 F. Hoffmann-La Roche AG Methods and systems for predicting cancer therapy response
CN114931637B (zh) * 2022-06-27 2025-02-18 中山大学中山眼科中心 Pdl1抗体在角膜新生血管疾病中的应用
CN116449009B (zh) * 2023-01-30 2026-05-08 上海秤信生物科技有限公司 预测肺癌三期患者的免疫新辅助疗效的自身抗体标志物
AU2024362581A1 (en) * 2023-10-19 2026-04-30 Tesaro, Inc. Methods of treating cancer with anti-pd-1 agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015518826A (ja) 2012-05-15 2015-07-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔ Ｐｄ−１／ｐｄ−ｌ１シグナル伝達を破壊することによる癌免疫療法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1210428E (pt) 1999-08-23 2015-07-21 Genetics Inst Llc Pd-1, um recetor para b7-4 e suas utilizações
WO2004056875A1 (en) 2002-12-23 2004-07-08 Wyeth Antibodies against pd-1 and uses therefor
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
CA2612241C (en) 2005-07-01 2018-11-06 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
KR101586617B1 (ko) 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
EP4209510B1 (en) 2008-12-09 2024-01-31 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
NO2504364T3 (enExample) 2009-11-24 2018-01-06
SI2699264T1 (en) 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
US9624298B2 (en) 2011-11-28 2017-04-18 Merck Patent Gmbh Anti-PD-L1 antibodies and uses thereof
AU2013267161A1 (en) 2012-05-31 2014-11-20 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
JP6742903B2 (ja) 2013-05-02 2020-08-19 アナプティスバイオ インコーポレイティッド プログラム死−１（ｐｄ−１）に対する抗体
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
CN104250302B (zh) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 抗pd‑1抗体及其应用
LT3702373T (lt) 2013-09-13 2022-11-10 Beigene Switzerland Gmbh Anti-pd1 antikūnai ir jų naudojimas terapijai ir diagnostikai
HUE046249T2 (hu) 2013-12-12 2020-02-28 Shanghai hengrui pharmaceutical co ltd PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása
DE112014005975T5 (de) * 2013-12-17 2016-09-15 Kymab Limited Menschliche Ziele
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
CA2935423C (en) 2014-01-24 2023-11-07 Dana-Farber Cancer Institute, Inc. Antibody molecules to pd-1 and uses thereof
AU2015210886A1 (en) * 2014-01-29 2016-09-01 Caris Mpi, Inc. Molecular profiling of immune modulators
WO2015164743A2 (en) * 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
DK3237446T3 (en) 2014-12-22 2021-07-26 Pd 1 Acquisition Group Llc Anti-PD-1-antistoffer
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
US20180155429A1 (en) * 2015-05-28 2018-06-07 Bristol-Myers Squibb Company Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
EP3307777A4 (en) 2015-06-11 2019-02-13 Wuxi Biologics (Shanghai) Co. Ltd. NOVEL ANTI-PD-L1 ANTIBODIES
AU2016298227B9 (en) 2015-07-30 2019-10-31 Macrogenics, Inc. PD-1-binding molecules and methods of use thereof
WO2017020291A1 (en) 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
MX392711B (es) 2015-08-11 2025-03-24 Wuxi Biologics Ireland Ltd Anticuerpos anti-pd-1 novedosos.
WO2017024515A1 (en) 2015-08-11 2017-02-16 Wuxi Biologics (Cayman) Inc. Novel anti-pd-1 antibodies
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
EP3344656A1 (en) 2015-09-01 2018-07-11 Agenus Inc. Anti-pd-1 antibodies and methods of use thereof
CA2996685A1 (en) 2015-09-03 2017-03-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP6955507B2 (ja) 2015-12-14 2021-10-27 マクロジェニクス，インコーポレーテッド Ｐｄ‐１及びｃｔｌａ‐４との免疫応答性を有する二重特異性並びにその使用方法
MX2018007295A (es) 2016-01-11 2019-03-28 Armo Biosciences Inc Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos.
WO2017132827A1 (en) 2016-02-02 2017-08-10 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
CN111385767A (zh) 2016-02-02 2020-07-07 华为技术有限公司 确定发射功率的方法、用户设备和基站
CN109476753A (zh) 2016-06-03 2019-03-15 百时美施贵宝公司 用于治疗肿瘤的方法的抗-pd-1抗体
JP7780857B2 (ja) 2017-06-01 2025-12-05 ブリストル－マイヤーズ スクイブ カンパニー 抗ｐｄ－１抗体を用いる腫瘍の治療方法
CN113249483B (zh) * 2021-06-10 2021-10-08 北京泛生子基因科技有限公司 一种检测肿瘤突变负荷的基因组合、系统及应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015518826A (ja) 2012-05-15 2015-07-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔ Ｐｄ−１／ｐｄ−ｌ１シグナル伝達を破壊することによる癌免疫療法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Clin. Oncol., 2017, Vol. 35, No. 15 suppl, p.9016, Published online May 30, 2017
Mol. Cell. Oncol., 2016, Vol. 3, No. 1, e1048929

Also Published As

Publication number Publication date
KR20240149982A (ko) 2024-10-15
US20230279114A1 (en) 2023-09-07
US20250145713A1 (en) 2025-05-08
KR20200014363A (ko) 2020-02-10
US11566073B2 (en) 2023-01-31
KR102714702B1 (ko) 2024-10-10
JP2026053613A (ja) 2026-03-25
CN117462668A (zh) 2024-01-30
EP3630840A1 (en) 2020-04-08
US20200109204A1 (en) 2020-04-09
CN110678483B (zh) 2023-09-22
WO2018223040A1 (en) 2018-12-06
CN110678483A (zh) 2020-01-10
JP2020522508A (ja) 2020-07-30
US12227576B2 (en) 2025-02-18
JP2023159179A (ja) 2023-10-31

Similar Documents

Publication Publication Date Title
US12227576B2 (en) Methods of treating a tumor using an anti-PD-1 antibody
US12466888B2 (en) Methods of treating tumor
US20230295737A1 (en) Methods of treating tumor
US20240190963A1 (en) Methods of treating tumor
US12479917B2 (en) Methods of treating NSCLC comprising administering platinum doublet chemotherapy followed by an anti-PD-1 antibody and an anti-CTLA-4 antibody
TW201731527A (zh) 使用抗ｐｄ－１抗體與抗ｃｌｔａ－４抗體之組合以治療肺癌
US20260042840A1 (en) Methods of treating tumor
JP7862139B2 (ja) 腫瘍を処置する方法
EA046134B1 (ru) Способы лечения опухоли

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210531

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210531

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220316

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220621

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220920

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230216

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230404

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230804

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20230810

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20231013

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20240502

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20250217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250827

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20251125

R150 Certificate of patent or registration of utility model

Ref document number: 7780857

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150