KR102714702B1 - 항-pd-1 항체를 사용하여 종양을 치료하는 방법 - Google Patents
항-pd-1 항체를 사용하여 종양을 치료하는 방법 Download PDFInfo
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- KR102714702B1 KR102714702B1 KR1020197038639A KR20197038639A KR102714702B1 KR 102714702 B1 KR102714702 B1 KR 102714702B1 KR 1020197038639 A KR1020197038639 A KR 1020197038639A KR 20197038639 A KR20197038639 A KR 20197038639A KR 102714702 B1 KR102714702 B1 KR 102714702B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020247032911A KR20240149982A (ko) | 2017-06-01 | 2018-06-01 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513831P | 2017-06-01 | 2017-06-01 | |
| US62/513,831 | 2017-06-01 | ||
| PCT/US2018/035670 WO2018223040A1 (en) | 2017-06-01 | 2018-06-01 | Methods of treating a tumor using an anti-pd-1 antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247032911A Division KR20240149982A (ko) | 2017-06-01 | 2018-06-01 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200014363A KR20200014363A (ko) | 2020-02-10 |
| KR102714702B1 true KR102714702B1 (ko) | 2024-10-10 |
Family
ID=62685228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197038639A Active KR102714702B1 (ko) | 2017-06-01 | 2018-06-01 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
| KR1020247032911A Pending KR20240149982A (ko) | 2017-06-01 | 2018-06-01 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247032911A Pending KR20240149982A (ko) | 2017-06-01 | 2018-06-01 | 항-pd-1 항체를 사용하여 종양을 치료하는 방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11566073B2 (enExample) |
| EP (1) | EP3630840A1 (enExample) |
| JP (2) | JP7780857B2 (enExample) |
| KR (2) | KR102714702B1 (enExample) |
| CN (2) | CN117462668A (enExample) |
| WO (1) | WO2018223040A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9856320B2 (en) * | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| FI3334763T3 (fi) | 2015-08-11 | 2024-10-30 | Wuxi Biologics Ireland Ltd | Uusia pd-l1-vasta-aineita |
| US11566073B2 (en) | 2017-06-01 | 2023-01-31 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-PD-1 antibody |
| KR20200119844A (ko) * | 2018-02-13 | 2020-10-20 | 머크 샤프 앤드 돔 코포레이션 | 항-pd-1 항체를 사용한 암의 치료 방법 |
| CN111821434A (zh) * | 2019-04-17 | 2020-10-27 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
| US20220081724A1 (en) * | 2018-12-19 | 2022-03-17 | Strata Oncology, Inc. | Methods of detecting and treating subjects with checkpoint inhibitor-responsive cancer |
| JP2022530674A (ja) * | 2019-05-03 | 2022-06-30 | ジェネンテック, インコーポレイテッド | 抗pd-l1抗体を用いたがんの処置方法 |
| US12275986B2 (en) * | 2020-01-06 | 2025-04-15 | Duke University | Biomarkers associated with checkpoint immune therapy and methods of using same |
| CN110923329B (zh) * | 2020-02-06 | 2020-05-12 | 至本医疗科技(上海)有限公司 | Fgfr4点突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| CN111440822A (zh) * | 2020-04-16 | 2020-07-24 | 苏州大学附属第二医院 | 一种突变lats1质粒的构建与应用 |
| CN112961920A (zh) * | 2021-03-24 | 2021-06-15 | 臻和(北京)生物科技有限公司 | 一种预测肝胆肿瘤患者免疫检查点抑制剂联合靶向治疗疗效的方法及产品 |
| JP2023025595A (ja) * | 2021-08-10 | 2023-02-22 | 国立大学法人 新潟大学 | 内胚葉嚢胞の悪性化に関連する遺伝子の検出方法 |
| CN113943806A (zh) * | 2021-11-04 | 2022-01-18 | 至本医疗科技(上海)有限公司 | 预测肺腺癌患者对免疫疗法敏感性的生物标志物、应用和装置 |
| US20250349434A1 (en) * | 2022-04-26 | 2025-11-13 | Hoffmann-La Roche Inc. | Methods and systems for predicting cancer therapy response |
| CN114931637B (zh) * | 2022-06-27 | 2025-02-18 | 中山大学中山眼科中心 | Pdl1抗体在角膜新生血管疾病中的应用 |
| CN115825441B (zh) * | 2023-01-30 | 2023-05-26 | 上海秤信生物科技有限公司 | 预测肺癌三期患者的免疫新辅助疗效的自身抗体标志物 |
| WO2025085707A1 (en) * | 2023-10-19 | 2025-04-24 | Tesaro, Inc. | Methods of treating cancer with anti-pd-1 agents |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| PL2699264T3 (pl) | 2011-04-20 | 2018-08-31 | Medimmune, Llc | Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1 |
| EP2785375B1 (en) | 2011-11-28 | 2020-07-22 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
| US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| CN104736168B (zh) | 2012-05-31 | 2018-09-21 | 索伦托治疗有限公司 | 与pd-l1结合的抗原结合蛋白 |
| HRP20210122T1 (hr) | 2013-05-02 | 2021-04-16 | Anaptysbio, Inc. | Protutijela usmjerena protiv programirane smrti-1 (pd-1) |
| CN111423511B (zh) | 2013-05-31 | 2024-02-23 | 索伦托药业有限公司 | 与pd-1结合的抗原结合蛋白 |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| ES2792183T3 (es) | 2013-09-13 | 2020-11-10 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| CN106062004A (zh) * | 2013-12-17 | 2016-10-26 | 科马布有限公司 | 人靶标 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| AU2015210886A1 (en) * | 2014-01-29 | 2016-09-01 | Caris Mpi, Inc. | Molecular profiling of immune modulators |
| US11624093B2 (en) * | 2014-04-24 | 2023-04-11 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| CA2971734C (en) | 2014-12-22 | 2025-11-18 | Enumeral Biomedical Holdings Inc | Anti-pd-1 antibodies |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| WO2016191751A1 (en) * | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| EP3307777A4 (en) | 2015-06-11 | 2019-02-13 | Wuxi Biologics (Shanghai) Co. Ltd. | NOVEL ANTI-PD-L1 ANTIBODIES |
| CN116333138A (zh) | 2015-07-30 | 2023-06-27 | 宏观基因有限公司 | Pd-1结合分子和其使用方法 |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| WO2017024515A1 (en) | 2015-08-11 | 2017-02-16 | Wuxi Biologics (Cayman) Inc. | Novel anti-pd-1 antibodies |
| FI3334763T3 (fi) | 2015-08-11 | 2024-10-30 | Wuxi Biologics Ireland Ltd | Uusia pd-l1-vasta-aineita |
| AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| HK1257840A1 (zh) | 2015-09-01 | 2019-11-01 | Agenus Inc. | 抗-pd-1抗体及其使用方法 |
| KR20180043835A (ko) | 2015-09-03 | 2018-04-30 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 매크로사이클 및 이의 용도 |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| EP3402512A4 (en) | 2016-01-11 | 2019-09-25 | Armo Biosciences, Inc. | INTERLEUKIN-10 IN THE PREPARATION OF ANTIGEN-SPECIFIC CD8 + T CELLS AND METHOD FOR THE USE THEREOF |
| WO2017132827A1 (en) | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| CN111491362B (zh) | 2016-02-02 | 2023-10-24 | 华为技术有限公司 | 确定发射功率的方法、用户设备和基站 |
| KR20250107295A (ko) | 2016-06-03 | 2025-07-11 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체 |
| US11566073B2 (en) | 2017-06-01 | 2023-01-31 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-PD-1 antibody |
| CN113249483B (zh) * | 2021-06-10 | 2021-10-08 | 北京泛生子基因科技有限公司 | 一种检测肿瘤突变负荷的基因组合、系统及应用 |
-
2018
- 2018-06-01 US US16/617,725 patent/US11566073B2/en active Active
- 2018-06-01 WO PCT/US2018/035670 patent/WO2018223040A1/en not_active Ceased
- 2018-06-01 CN CN202311104154.0A patent/CN117462668A/zh active Pending
- 2018-06-01 JP JP2019566619A patent/JP7780857B2/ja active Active
- 2018-06-01 KR KR1020197038639A patent/KR102714702B1/ko active Active
- 2018-06-01 CN CN201880035434.1A patent/CN110678483B/zh active Active
- 2018-06-01 EP EP18733121.0A patent/EP3630840A1/en active Pending
- 2018-06-01 KR KR1020247032911A patent/KR20240149982A/ko active Pending
-
2023
- 2023-01-30 US US18/161,713 patent/US12227576B2/en active Active
- 2023-08-04 JP JP2023127759A patent/JP2023159179A/ja active Pending
-
2025
- 2025-01-09 US US19/015,341 patent/US20250145713A1/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| Andreas H. Scheel, et al., Oncoimmunology, 2016, 5(5), e1131379.* |
| Luisa Carbognin, et al., PLoS ONE, 2015, 10(6), e0130142.* |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023159179A (ja) | 2023-10-31 |
| EP3630840A1 (en) | 2020-04-08 |
| JP2020522508A (ja) | 2020-07-30 |
| US20250145713A1 (en) | 2025-05-08 |
| US20200109204A1 (en) | 2020-04-09 |
| CN117462668A (zh) | 2024-01-30 |
| CN110678483A (zh) | 2020-01-10 |
| WO2018223040A1 (en) | 2018-12-06 |
| KR20200014363A (ko) | 2020-02-10 |
| US12227576B2 (en) | 2025-02-18 |
| JP7780857B2 (ja) | 2025-12-05 |
| US20230279114A1 (en) | 2023-09-07 |
| US11566073B2 (en) | 2023-01-31 |
| KR20240149982A (ko) | 2024-10-15 |
| CN110678483B (zh) | 2023-09-22 |
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