JP2020522508A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020522508A5 JP2020522508A5 JP2019566619A JP2019566619A JP2020522508A5 JP 2020522508 A5 JP2020522508 A5 JP 2020522508A5 JP 2019566619 A JP2019566619 A JP 2019566619A JP 2019566619 A JP2019566619 A JP 2019566619A JP 2020522508 A5 JP2020522508 A5 JP 2020522508A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tumor
- antibody according
- subject
- identified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023127759A JP2023159179A (ja) | 2017-06-01 | 2023-08-04 | 抗ｐｄ－１抗体を用いる腫瘍の治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513831P | 2017-06-01 | 2017-06-01 | |
| US62/513,831 | 2017-06-01 | ||
| PCT/US2018/035670 WO2018223040A1 (en) | 2017-06-01 | 2018-06-01 | Methods of treating a tumor using an anti-pd-1 antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127759A Division JP2023159179A (ja) | 2017-06-01 | 2023-08-04 | 抗ｐｄ－１抗体を用いる腫瘍の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522508A JP2020522508A (ja) | 2020-07-30 |
| JP2020522508A5 true JP2020522508A5 (enExample) | 2021-07-26 |
| JP7780857B2 JP7780857B2 (ja) | 2025-12-05 |
Family
ID=62685228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566619A Active JP7780857B2 (ja) | 2017-06-01 | 2018-06-01 | 抗ｐｄ－１抗体を用いる腫瘍の治療方法 |
| JP2023127759A Pending JP2023159179A (ja) | 2017-06-01 | 2023-08-04 | 抗ｐｄ－１抗体を用いる腫瘍の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127759A Pending JP2023159179A (ja) | 2017-06-01 | 2023-08-04 | 抗ｐｄ－１抗体を用いる腫瘍の治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11566073B2 (enExample) |
| EP (1) | EP3630840A1 (enExample) |
| JP (2) | JP7780857B2 (enExample) |
| KR (2) | KR102714702B1 (enExample) |
| CN (2) | CN117462668A (enExample) |
| WO (1) | WO2018223040A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9856320B2 (en) * | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| FI3334763T3 (fi) | 2015-08-11 | 2024-10-30 | Wuxi Biologics Ireland Ltd | Uusia pd-l1-vasta-aineita |
| US11566073B2 (en) | 2017-06-01 | 2023-01-31 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-PD-1 antibody |
| KR20200119844A (ko) * | 2018-02-13 | 2020-10-20 | 머크 샤프 앤드 돔 코포레이션 | 항-pd-1 항체를 사용한 암의 치료 방법 |
| CN111821434A (zh) * | 2019-04-17 | 2020-10-27 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
| US20220081724A1 (en) * | 2018-12-19 | 2022-03-17 | Strata Oncology, Inc. | Methods of detecting and treating subjects with checkpoint inhibitor-responsive cancer |
| JP2022530674A (ja) * | 2019-05-03 | 2022-06-30 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体を用いたがんの処置方法 |
| US12275986B2 (en) * | 2020-01-06 | 2025-04-15 | Duke University | Biomarkers associated with checkpoint immune therapy and methods of using same |
| CN110923329B (zh) * | 2020-02-06 | 2020-05-12 | 至本医疗科技（上海）有限公司 | Fgfr4点突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| CN111440822A (zh) * | 2020-04-16 | 2020-07-24 | 苏州大学附属第二医院 | 一种突变lats1质粒的构建与应用 |
| CN112961920A (zh) * | 2021-03-24 | 2021-06-15 | 臻和(北京)生物科技有限公司 | 一种预测肝胆肿瘤患者免疫检查点抑制剂联合靶向治疗疗效的方法及产品 |
| JP2023025595A (ja) * | 2021-08-10 | 2023-02-22 | 国立大学法人 新潟大学 | 内胚葉嚢胞の悪性化に関連する遺伝子の検出方法 |
| CN113943806A (zh) * | 2021-11-04 | 2022-01-18 | 至本医疗科技（上海）有限公司 | 预测肺腺癌患者对免疫疗法敏感性的生物标志物、应用和装置 |
| US20250349434A1 (en) * | 2022-04-26 | 2025-11-13 | Hoffmann-La Roche Inc. | Methods and systems for predicting cancer therapy response |
| CN114931637B (zh) * | 2022-06-27 | 2025-02-18 | 中山大学中山眼科中心 | Pdl1抗体在角膜新生血管疾病中的应用 |
| CN115825441B (zh) * | 2023-01-30 | 2023-05-26 | 上海秤信生物科技有限公司 | 预测肺癌三期患者的免疫新辅助疗效的自身抗体标志物 |
| WO2025085707A1 (en) * | 2023-10-19 | 2025-04-24 | Tesaro, Inc. | Methods of treating cancer with anti-pd-1 agents |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1210428B1 (en) | 1999-08-23 | 2015-03-18 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| PL2699264T3 (pl) | 2011-04-20 | 2018-08-31 | Medimmune, Llc | Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1 |
| EP2785375B1 (en) | 2011-11-28 | 2020-07-22 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
| US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| CN104736168B (zh) | 2012-05-31 | 2018-09-21 | 索伦托治疗有限公司 | 与pd-l1结合的抗原结合蛋白 |
| HRP20210122T1 (hr) | 2013-05-02 | 2021-04-16 | Anaptysbio, Inc. | Protutijela usmjerena protiv programirane smrti-1 (pd-1) |
| CN111423511B (zh) | 2013-05-31 | 2024-02-23 | 索伦托药业有限公司 | 与pd-1结合的抗原结合蛋白 |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| ES2792183T3 (es) | 2013-09-13 | 2020-11-10 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| CN106062004A (zh) * | 2013-12-17 | 2016-10-26 | 科马布有限公司 | 人靶标 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| AU2015210886A1 (en) * | 2014-01-29 | 2016-09-01 | Caris Mpi, Inc. | Molecular profiling of immune modulators |
| US11624093B2 (en) * | 2014-04-24 | 2023-04-11 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| CA2971734C (en) | 2014-12-22 | 2025-11-18 | Enumeral Biomedical Holdings Inc | Anti-pd-1 antibodies |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| WO2016191751A1 (en) * | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| EP3307777A4 (en) | 2015-06-11 | 2019-02-13 | Wuxi Biologics (Shanghai) Co. Ltd. | NOVEL ANTI-PD-L1 ANTIBODIES |
| CN116333138A (zh) | 2015-07-30 | 2023-06-27 | 宏观基因有限公司 | Pd-1结合分子和其使用方法 |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| WO2017024515A1 (en) | 2015-08-11 | 2017-02-16 | Wuxi Biologics (Cayman) Inc. | Novel anti-pd-1 antibodies |
| FI3334763T3 (fi) | 2015-08-11 | 2024-10-30 | Wuxi Biologics Ireland Ltd | Uusia pd-l1-vasta-aineita |
| AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| HK1257840A1 (zh) | 2015-09-01 | 2019-11-01 | Agenus Inc. | 抗-pd-1抗体及其使用方法 |
| KR20180043835A (ko) | 2015-09-03 | 2018-04-30 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 매크로사이클 및 이의 용도 |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| EP3402512A4 (en) | 2016-01-11 | 2019-09-25 | Armo Biosciences, Inc. | INTERLEUKIN-10 IN THE PREPARATION OF ANTIGEN-SPECIFIC CD8 + T CELLS AND METHOD FOR THE USE THEREOF |
| WO2017132827A1 (en) | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| CN111491362B (zh) | 2016-02-02 | 2023-10-24 | 华为技术有限公司 | 确定发射功率的方法、用户设备和基站 |
| KR20250107295A (ko) | 2016-06-03 | 2025-07-11 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체 |
| US11566073B2 (en) | 2017-06-01 | 2023-01-31 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-PD-1 antibody |
| CN113249483B (zh) * | 2021-06-10 | 2021-10-08 | 北京泛生子基因科技有限公司 | 一种检测肿瘤突变负荷的基因组合、系统及应用 |
-
2018
- 2018-06-01 US US16/617,725 patent/US11566073B2/en active Active
- 2018-06-01 WO PCT/US2018/035670 patent/WO2018223040A1/en not_active Ceased
- 2018-06-01 CN CN202311104154.0A patent/CN117462668A/zh active Pending
- 2018-06-01 JP JP2019566619A patent/JP7780857B2/ja active Active
- 2018-06-01 KR KR1020197038639A patent/KR102714702B1/ko active Active
- 2018-06-01 CN CN201880035434.1A patent/CN110678483B/zh active Active
- 2018-06-01 EP EP18733121.0A patent/EP3630840A1/en active Pending
- 2018-06-01 KR KR1020247032911A patent/KR20240149982A/ko active Pending
-
2023
- 2023-01-30 US US18/161,713 patent/US12227576B2/en active Active
- 2023-08-04 JP JP2023127759A patent/JP2023159179A/ja active Pending
-
2025
- 2025-01-09 US US19/015,341 patent/US20250145713A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020522508A5 (enExample) | ||
| Subbiah et al. | Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations | |
| Awad et al. | Impact of MET inhibitors on survival among patients with non-small cell lung cancer harboring MET exon 14 mutations: a retrospective analysis | |
| Lamberti et al. | Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer | |
| Papadimitriou et al. | The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality | |
| Brown et al. | Targeting DNA repair in cancer: beyond PARP inhibitors | |
| Schmitt et al. | ATM deficiency is associated with sensitivity to PARP1-and ATR inhibitors in lung adenocarcinoma | |
| Beaver et al. | PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system | |
| Martinelli et al. | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells | |
| Becker et al. | Retreatment with erlotinib: regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment | |
| JP2013523744A5 (enExample) | ||
| Pu et al. | Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance | |
| JP2017214436A5 (enExample) | ||
| ES2686549T3 (es) | Método para seleccionar una triterapia personalizada para el tratamiento del cáncer | |
| Nelson et al. | Implications of DNA damage and DNA repair on human diseases | |
| Qin et al. | Basket trials for intractable cancer | |
| Ischenko et al. | A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells | |
| Nishio et al. | RELAY, ramucirumab plus erlotinib (RAM+ ERL) in untreated metastatic EGFR-mutant NSCLC (EGFR+ NSCLC): association between TP53 status and clinical outcome | |
| Xue et al. | Therapeutic evaluation of palbociclib and its compatibility with other chemotherapies for primary and recurrent nasopharyngeal carcinoma | |
| CN115998872B (zh) | 一种含有抑制核酸内切酶功能的药物及其抗肿瘤的用途 | |
| Cui et al. | Expert opinion on translational research for advanced glioblastoma treatment | |
| Fang et al. | Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies | |
| Kulkarni et al. | Poly (ADP-ribose) polymerase inhibitor therapy and mechanisms of resistance in epithelial ovarian cancer | |
| Wu et al. | Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis | |
| Kim et al. | Randomized phase II study of pemetrexed versus gefitinib in previously treated patients with advanced non-small cell lung cancer |