JP7706456B2 - Ｓｍａｒｃａ２－ｖｈｌ分解剤 - Google Patents

Ｓｍａｒｃａ２－ｖｈｌ分解剤 Download PDF

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JP7706456B2
JP7706456B2 JP2022541815A JP2022541815A JP7706456B2 JP 7706456 B2 JP7706456 B2 JP 7706456B2 JP 2022541815 A JP2022541815 A JP 2022541815A JP 2022541815 A JP2022541815 A JP 2022541815A JP 7706456 B2 JP7706456 B2 JP 7706456B2
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mmol
cancer
amino
piperazin
compound
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Japanese (ja)
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JP2023510746A5 (https=
JP2023510746A (ja
Inventor
バナジー，アビシェク
シー，ビクター・ジェイ
チェン，ニン
リ，シャオフェン
ブルツ，ライアン・ポール
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2022541815A 2020-01-10 2021-01-08 Ｓｍａｒｃａ２－ｖｈｌ分解剤 Active JP7706456B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062959502P 2020-01-10 2020-01-10
US62/959,502 2020-01-10
PCT/US2021/012683 WO2021142247A1 (en) 2020-01-10 2021-01-08 Smarca2-vhl degraders

Publications (3)

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JP2023510746A JP2023510746A (ja) 2023-03-15
JP2023510746A5 JP2023510746A5 (https=) 2024-01-16
JP7706456B2 true JP7706456B2 (ja) 2025-07-11

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ID=74495106

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JP2022541815A Active JP7706456B2 (ja) 2020-01-10 2021-01-08 Ｓｍａｒｃａ２－ｖｈｌ分解剤

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US (1) US20230091042A1 (https=)
EP (1) EP4087658A1 (https=)
JP (1) JP7706456B2 (https=)
AU (1) AU2021205326A1 (https=)
CA (1) CA3167166A1 (https=)
MX (1) MX2022008487A (https=)
WO (1) WO2021142247A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020251972A1 (en) 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
WO2021133917A1 (en) 2019-12-23 2021-07-01 Kymera Therapeutics, Inc. Smarca inhibitors and uses thereof
EP4081308A4 (en) 2019-12-23 2024-01-24 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
US12570650B2 (en) * 2020-08-04 2026-03-10 Aurigene Oncology Limited 6-substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degraders
EP4259144A4 (en) * 2020-12-09 2025-08-20 Kymera Therapeutics Inc SMARCA DEGRADING AGENTS AND THEIR USES
KR20240046498A (ko) 2021-08-09 2024-04-09 제넨테크, 인크. Brm의 조절에 사용하기 위한 페놀 유도체

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019123367A1 (en) 2017-12-21 2019-06-27 Astrazeneca Ab Compounds and their use in treating cancer
WO2019207538A1 (en) 2018-04-26 2019-10-31 Aurigene Discovery Technologies Limited Pyridazine derivatives as smarca2/4 degraders
WO2019213005A1 (en) 2018-04-30 2019-11-07 Dana-Farber Cancer Institute, Inc. Small molecule degraders of polybromo-1 (pbrm1)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190300521A1 (en) * 2018-04-01 2019-10-03 Arvinas Operations, Inc. Brm targeting compounds and associated methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019123367A1 (en) 2017-12-21 2019-06-27 Astrazeneca Ab Compounds and their use in treating cancer
WO2019207538A1 (en) 2018-04-26 2019-10-31 Aurigene Discovery Technologies Limited Pyridazine derivatives as smarca2/4 degraders
WO2019213005A1 (en) 2018-04-30 2019-11-07 Dana-Farber Cancer Institute, Inc. Small molecule degraders of polybromo-1 (pbrm1)

Also Published As

Publication number Publication date
US20230091042A1 (en) 2023-03-23
WO2021142247A1 (en) 2021-07-15
EP4087658A1 (en) 2022-11-16
MX2022008487A (es) 2022-08-02
CA3167166A1 (en) 2021-07-15
JP2023510746A (ja) 2023-03-15
AU2021205326A1 (en) 2022-07-21

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