JP7705348B2 - 睡眠時無呼吸を治療するための方法および組成物 - Google Patents

睡眠時無呼吸を治療するための方法および組成物 Download PDF

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JP7705348B2
JP7705348B2 JP2021546285A JP2021546285A JP7705348B2 JP 7705348 B2 JP7705348 B2 JP 7705348B2 JP 2021546285 A JP2021546285 A JP 2021546285A JP 2021546285 A JP2021546285 A JP 2021546285A JP 7705348 B2 JP7705348 B2 JP 7705348B2
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atomoxetine
pharmaceutical composition
sleep
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JP2022519721A (ja
JPWO2020163785A5 (https=
JP2022519721A5 (https=
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タラント モンテムロ，ルイジ
ウェルマン，ディー．アンドリュー
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Brigham and Womens Hospital Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021546285A 2019-02-08 2020-02-07 睡眠時無呼吸を治療するための方法および組成物 Active JP7705348B2 (ja)

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JP2025016270A JP2025084754A (ja) 2019-02-08 2025-02-03 睡眠時無呼吸を治療するための方法および組成物

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US201962803223P 2019-02-08 2019-02-08
US62/803,223 2019-02-08
PCT/US2020/017323 WO2020163785A1 (en) 2019-02-08 2020-02-07 Methods and compositions for treating sleep apnea

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JP2022519721A JP2022519721A (ja) 2022-03-24
JPWO2020163785A5 JPWO2020163785A5 (https=) 2023-02-15
JP2022519721A5 JP2022519721A5 (https=) 2023-02-15
JP7705348B2 true JP7705348B2 (ja) 2025-07-09

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JP2025016270A Pending JP2025084754A (ja) 2019-02-08 2025-02-03 睡眠時無呼吸を治療するための方法および組成物

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US (1) US12558327B2 (https=)
EP (2) EP4635514A3 (https=)
JP (2) JP7705348B2 (https=)
KR (1) KR20210125507A (https=)
CN (2) CN118557736A (https=)
AU (2) AU2020219809B2 (https=)
BR (1) BR112021015600A2 (https=)
CA (1) CA3129270A1 (https=)
EA (1) EA202192202A1 (https=)
ES (1) ES3049086T3 (https=)
IL (1) IL285197A (https=)
MX (2) MX2021009407A (https=)
MY (1) MY210043A (https=)
PH (1) PH12021551850A1 (https=)
SG (1) SG11202108225QA (https=)
UA (1) UA130366C2 (https=)
WO (1) WO2020163785A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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EP3746126B1 (en) 2018-01-30 2024-07-31 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea or simple snoring
EP4635514A3 (en) 2019-02-08 2025-12-24 The Brigham & Women's Hospital, Inc. Methods and compositions for treating sleep apnea
GEAP202416361A (en) * 2021-03-24 2024-04-25 Apnimed Inc Delaware Methods and compositions for treating sleep apnea
KR20240021920A (ko) * 2021-06-17 2024-02-19 애프니메드, 인코포레이티드 (델라웨어) 수면 무호흡증을 치료하기 위한 노르에피네프린 재흡수 억제제
US20250302814A1 (en) * 2022-05-13 2025-10-02 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
CN119789855A (zh) * 2022-09-02 2025-04-08 爱普宁公司(特拉华) 治疗睡眠呼吸暂停的方法和组合物

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WO2018200775A1 (en) 2017-04-28 2018-11-01 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea

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WO2018200775A1 (en) 2017-04-28 2018-11-01 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea

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Publication number Publication date
AU2025205464A1 (en) 2025-07-31
EP3920898C0 (en) 2025-09-10
JP2025084754A (ja) 2025-06-03
CN118557736A (zh) 2024-08-30
JP2022519721A (ja) 2022-03-24
CN113692277A (zh) 2021-11-23
US20220096401A1 (en) 2022-03-31
UA130366C2 (uk) 2026-02-04
WO2020163785A1 (en) 2020-08-13
EP4635514A2 (en) 2025-10-22
KR20210125507A (ko) 2021-10-18
IL285197A (en) 2021-09-30
AU2020219809A1 (en) 2021-08-19
BR112021015600A2 (pt) 2021-10-05
MY210043A (en) 2025-08-22
EA202192202A1 (ru) 2021-11-03
CN113692277B (zh) 2024-07-16
EP3920898B1 (en) 2025-09-10
MX2021009407A (es) 2021-09-10
AU2020219809B2 (en) 2025-04-17
EP3920898A1 (en) 2021-12-15
EP4635514A3 (en) 2025-12-24
PH12021551850A1 (en) 2022-05-11
MX2025004365A (es) 2025-05-02
US12558327B2 (en) 2026-02-24
SG11202108225QA (en) 2021-08-30
ES3049086T3 (en) 2025-12-12
EP3920898A4 (en) 2022-11-09
CA3129270A1 (en) 2020-08-13

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