JP7696897B2 - ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 - Google Patents

ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 Download PDF

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JP7696897B2
JP7696897B2 JP2022532829A JP2022532829A JP7696897B2 JP 7696897 B2 JP7696897 B2 JP 7696897B2 JP 2022532829 A JP2022532829 A JP 2022532829A JP 2022532829 A JP2022532829 A JP 2022532829A JP 7696897 B2 JP7696897 B2 JP 7696897B2
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ethyl
tetrahydro
dioxide
liver
oxy
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JP2023504643A (ja
JP2023504643A5 (enExample
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ペル－ヨーラン・ギルベリ
インゲマル・スタルケ
サントシュ・エス・クルカルニ
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アルビレオ・アクチボラグ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2022532829A 2019-12-04 2020-12-04 ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 Active JP7696897B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201911049984 2019-12-04
IN201911049984 2019-12-04
PCT/EP2020/084570 WO2021110886A1 (en) 2019-12-04 2020-12-04 Benzothia(di)azepine compounds and their use as bile acid modulators

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JP2023504643A JP2023504643A (ja) 2023-02-06
JP2023504643A5 JP2023504643A5 (enExample) 2023-12-05
JP7696897B2 true JP7696897B2 (ja) 2025-06-23

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US (2) US11267794B2 (enExample)
EP (1) EP4069361B1 (enExample)
JP (1) JP7696897B2 (enExample)
CN (1) CN114761080B (enExample)
AR (1) AR120676A1 (enExample)
CA (1) CA3158181A1 (enExample)
ES (1) ES2973355T3 (enExample)
TW (1) TWI871392B (enExample)
WO (1) WO2021110886A1 (enExample)

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JP7665621B2 (ja) 2019-12-04 2025-04-21 アルビレオ・アクチボラグ ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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CN117412955A (zh) 2021-06-03 2024-01-16 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
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EP4629997A1 (en) 2022-12-09 2025-10-15 Albireo AB Asbt inhibitors in the treatment of renal diseases
WO2024163962A1 (en) * 2023-02-03 2024-08-08 Hemoshear Therapeutics, Inc. 3-((1,1-dioxido-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)-2-fluoroacrylic acid derivatives as sodium taurocholate co-transporting polypeptide (ntcp) inhibitors for the treatment of cholestasis
WO2024240249A1 (zh) * 2023-05-25 2024-11-28 正大天晴药业集团股份有限公司 一种苯并噻二氮卓化合物及其用途
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