JP7692403B2 - トリスルフィド化合物又はセレノトリスルフィド化合物の製造方法 - Google Patents

トリスルフィド化合物又はセレノトリスルフィド化合物の製造方法 Download PDF

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JP7692403B2
JP7692403B2 JP2022512029A JP2022512029A JP7692403B2 JP 7692403 B2 JP7692403 B2 JP 7692403B2 JP 2022512029 A JP2022512029 A JP 2022512029A JP 2022512029 A JP2022512029 A JP 2022512029A JP 7692403 B2 JP7692403 B2 JP 7692403B2
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昌一郎 朝長
育実 下川
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Kyowa Pharma Chemical Co Ltd
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Kyowa Pharma Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D341/00—Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022512029A 2020-03-31 2021-03-24 トリスルフィド化合物又はセレノトリスルフィド化合物の製造方法 Active JP7692403B2 (ja)

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JP2020064262 2020-03-31
JP2020064262 2020-03-31
PCT/JP2021/012296 WO2021200487A1 (ja) 2020-03-31 2021-03-24 トリスルフィド化合物又はセレノトリスルフィド化合物の製造方法

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JPWO2021200487A1 JPWO2021200487A1 (https=) 2021-10-07
JP7692403B2 true JP7692403B2 (ja) 2025-06-13

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US (1) US20230192604A1 (https=)
EP (1) EP4129976A4 (https=)
JP (1) JP7692403B2 (https=)
CN (1) CN115087635B (https=)
WO (1) WO2021200487A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4342464A4 (en) 2021-07-08 2025-06-04 Kyowa Pharma Chemical Co., Ltd. PROPHYLACTIC OR THERAPEUTIC MEDICINE FOR PARKINSON'S DISEASE
EP4603087A1 (en) 2022-11-21 2025-08-20 Kyowa Hakko Bio Co., Ltd. Prophylactic or therapeutic agent for acute kidney injury induced by anticancer agent
CN115716817B (zh) * 2022-11-22 2024-04-19 国药集团威奇达药业有限公司 6,8-环三硫辛酸的制备方法
CN120390743A (zh) 2022-12-27 2025-07-29 协和医药化工股份有限公司 三硫化物化合物及其包合物
CN120344503A (zh) 2022-12-27 2025-07-18 协和医药化工股份有限公司 三硫化物化合物
WO2025070464A1 (ja) 2023-09-28 2025-04-03 協和ファーマケミカル株式会社 トリスルフィド化合物を含有する医薬組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018117186A1 (ja) 2016-12-20 2018-06-28 協和発酵バイオ株式会社 グルタチオントリスルフィド・２水和物の結晶及びその製造方法

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JPS6094979A (ja) * 1983-10-28 1985-05-28 Takeda Chem Ind Ltd １，２，３−トリチアン誘導体の新規製造法
US6187960B1 (en) * 1995-02-14 2001-02-13 Phillips Petroleum Company Process for producing organic polysulfide compounds
JP2014198688A (ja) * 2013-03-29 2014-10-23 住友精化株式会社 環状ポリスルフィド化合物の製造方法
CZ308144B6 (cs) * 2014-05-09 2020-01-22 Fakultní nemocnice Hradec Králové Způsob přípravy S-allylthioglutathionu, popřípadě ve směsi s S-allyldithioglutathionem, směs S-allylthioglutathionu s S-allyldithioglutathionem a S-allyldithioglutathion
CN107652264A (zh) 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2018117186A1 (ja) 2016-12-20 2018-06-28 協和発酵バイオ株式会社 グルタチオントリスルフィド・２水和物の結晶及びその製造方法

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Title
BANERJEE,A.，S-Ethyl Ethanethiosulfinate，e-EROS Encyclopedia of Reagents for Organic Synthesis，2008年，pp.1-3，DOI :10.1002/047084289X.RN00895
CAPOZZI, G. et al.，SILICON IN ORGANOSULPHUR CHEMISTRY. Part I. SYNTHESIS OF TRISULPHIDES，Tetrahedron Letters，Vo1.30, No.22，pp.2991-2994
GANTHER, H. E.，Reduction of the Selenotrisulfide Derivative of Glutathione to a Persulfide Analog by Glutathione Reductase，BIOCHEMISTRY，1971年，Vol.10, No.22，pp.4089-4098
IZMEST'EV, E. S. et al.，Oxidative transformations of diisobornyl disulfide，Russian Chemical Bulletin, International Edition，2014年，Vol.63, No.9，pp.2067-2073
KICE,J.L. et al.，Mechanism of the reaction of thiols with selenite，Journal of the American Chemical Society，1980年，Vol.102, No.13，pp.4448-4455
LEZINA, O. M. et al.，Reaction of Monoterpene Hydroxy Thiols with Chlorine Dioxide，Russian Journal of Organic Chemistry，2015年，Vol. 51, No. 10，pp.1359-1367，DOI: 10.1134/S1070428015100012
RYAN, M. D. and HARPP, D. N.，PREPARATION OF DITHIOSELENIDES VIA A SELENIUM TRANSFER REAGENT，Tetrahedron Letters，1997年，Vol. 38, No. 51，pp.8829-8832
石井 昭彦，vic-ジスルホキシド結合をもつ化合物の合成と性質，有機合成化学協会誌，2006年，Vol.64, No.4，pp.395-405
社団法人 日本化学会，新実験化学講座１４ 有機化合物の合成と反応ＩＩＩ，丸善株式会社，1978年，pp.1736-1738

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Publication number Publication date
JPWO2021200487A1 (https=) 2021-10-07
CN115087635A (zh) 2022-09-20
CN115087635B (zh) 2024-04-12
US20230192604A1 (en) 2023-06-22
WO2021200487A1 (ja) 2021-10-07
EP4129976A4 (en) 2024-05-29
EP4129976A1 (en) 2023-02-08

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