JP7668509B2 - 脂質合成の複素環式モジュレーター - Google Patents

脂質合成の複素環式モジュレーター Download PDF

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JP7668509B2
JP7668509B2 JP2019524943A JP2019524943A JP7668509B2 JP 7668509 B2 JP7668509 B2 JP 7668509B2 JP 2019524943 A JP2019524943 A JP 2019524943A JP 2019524943 A JP2019524943 A JP 2019524943A JP 7668509 B2 JP7668509 B2 JP 7668509B2
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alkyl
halogen
cycloalkyl
straight
branched chain
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JP2019533714A (ja
JP2019533714A5 (enExample
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ダグラス アイ. バックリー,
グレゴリー デューク,
アラン エス. ワグマン,
マーク エバンチック,
ロバート エス. マクダウェル,
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Sagimet Biosciences Inc
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3V Biosciences Inc
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Priority claimed from US15/349,960 external-priority patent/US20170119786A1/en
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Publication of JP2019533714A5 publication Critical patent/JP2019533714A5/ja
Priority to JP2023000165A priority Critical patent/JP2023033259A/ja
Priority to JP2024229040A priority patent/JP2025036565A/ja
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Priority to JP2026036572A priority patent/JP2026088159A/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN110078613B (zh) * 2019-05-31 2022-04-22 杭州科耀医药科技有限公司 一种2-卤-5-碘苯甲酸的合成方法
CN117567338A (zh) 2019-10-09 2024-02-20 拜耳公司 作为农药的新的杂芳基三唑化合物
CN114469945A (zh) * 2020-10-28 2022-05-13 歌礼生物科技(杭州)有限公司 脂肪酸合酶抑制剂的用途和药物组合物
EP4430535A4 (en) * 2021-11-11 2025-09-17 Sagimet Biosciences Inc METHODS FOR PREDICTING TREATMENT RESPONSE IN NONALCOHOLIC FATTY LIVER DISEASE
CN114436979B (zh) * 2022-02-22 2024-03-26 成都化润药业有限公司 一种合成1,2,4-三氮唑-3-羧酸甲酯的方法
JPWO2024172156A1 (enExample) * 2023-02-16 2024-08-22
CN119080742A (zh) * 2023-06-05 2024-12-06 甘莱制药有限公司 脂质合成的杂环调节剂的工业化制备
CN119868349B (zh) * 2023-10-23 2026-05-15 歌礼生物科技(杭州)有限公司 一种包含苯甲腈衍生物的药物组合物
WO2025086054A1 (zh) * 2023-10-23 2025-05-01 歌礼生物科技(杭州)有限公司 一种包含苯甲腈衍生物的药物组合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
WO2007052843A1 (ja) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
DE602006011363D1 (de) 2005-12-01 2010-02-04 Hoffmann La Roche Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008059214A1 (en) 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
WO2008075077A1 (en) 2006-12-21 2008-06-26 Astrazeneca Ab Piperidine derivatives for the treatment of obesity
TW200833663A (en) 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
TW200831092A (en) 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
EP2485678A4 (en) 2009-10-07 2013-04-03 Univ Cornell Coferons and methods of making and using them
JP2013520502A (ja) * 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
LT2683244T (lt) 2011-03-08 2017-04-10 3-V Biosciences, Inc. Lipidų sintezės heterocikliniai moduliatoriai
US9624173B2 (en) 2011-03-08 2017-04-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI522348B (zh) 2011-03-08 2016-02-21 3 V生物科技公司 脂質合成之雜環調節劑
KR102071095B1 (ko) 2012-07-03 2020-01-29 3-브이 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절인자
WO2014039769A1 (en) 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Imidazolin-5-one derivatives useful as fatty acid snthase (fasn) inhibitors for|the treatment of cancer
CA2932396C (en) * 2013-12-03 2022-03-29 Janssen Pharmaceutica Nv Benzamide derivative useful as fasn inhibitors for the treatment of cancer
CA2934257C (en) * 2013-12-17 2022-06-07 Janssen Pharmaceutica Nv Imidazolin-5-one derivative useful as fasn inhibitors for the treatment of cancer
CA2934251C (en) 2013-12-20 2024-01-02 3-V Biosciences, Inc. A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
JP6522007B2 (ja) * 2014-01-07 2019-05-29 3−ブイ・バイオサイエンシーズ・インコーポレイテッド3−V Biosciences,Inc. 癌及びウイルス感染症に対する使用のための脂質合成の複素環式モジュレータ
CU24395B1 (es) * 2014-03-17 2019-04-04 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
ES2833454T3 (es) 2014-08-15 2021-06-15 Sagimet Biosciences Inc Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente
JP6758314B2 (ja) 2015-03-19 2020-09-23 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式調節因子

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