AU2017356214B2 - Heterocyclic modulators of lipid synthesis - Google Patents

Heterocyclic modulators of lipid synthesis Download PDF

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Publication number
AU2017356214B2
AU2017356214B2 AU2017356214A AU2017356214A AU2017356214B2 AU 2017356214 B2 AU2017356214 B2 AU 2017356214B2 AU 2017356214 A AU2017356214 A AU 2017356214A AU 2017356214 A AU2017356214 A AU 2017356214A AU 2017356214 B2 AU2017356214 B2 AU 2017356214B2
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alkyl
halogen
cycloalkyl
straight
branched alkyl
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AU2017356214A1 (en
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Douglas I. Buckley
Gregory Duke
Marc EVANCHIK
Robert S. Mcdowell
Allan S. Wagman
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Sagimet Biosciences Inc
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Sagimet Biosciences Inc
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Priority claimed from US15/349,960 external-priority patent/US20170119786A1/en
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Assigned to SAGIMET BIOSCIENCES INC. reassignment SAGIMET BIOSCIENCES INC. Amend patent request/document other than specification (104) Assignors: 3-V BIOSCIENCES, INC.
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN110078613B (zh) * 2019-05-31 2022-04-22 杭州科耀医药科技有限公司 一种2-卤-5-碘苯甲酸的合成方法
CN117567338A (zh) 2019-10-09 2024-02-20 拜耳公司 作为农药的新的杂芳基三唑化合物
CN114469945A (zh) * 2020-10-28 2022-05-13 歌礼生物科技(杭州)有限公司 脂肪酸合酶抑制剂的用途和药物组合物
EP4430535A4 (en) * 2021-11-11 2025-09-17 Sagimet Biosciences Inc METHODS FOR PREDICTING TREATMENT RESPONSE IN NONALCOHOLIC FATTY LIVER DISEASE
CN114436979B (zh) * 2022-02-22 2024-03-26 成都化润药业有限公司 一种合成1,2,4-三氮唑-3-羧酸甲酯的方法
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CN119868349B (zh) * 2023-10-23 2026-05-15 歌礼生物科技(杭州)有限公司 一种包含苯甲腈衍生物的药物组合物
WO2025086054A1 (zh) * 2023-10-23 2025-05-01 歌礼生物科技(杭州)有限公司 一种包含苯甲腈衍生物的药物组合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122391A1 (en) * 2011-03-08 2012-09-13 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
WO2015095767A1 (en) * 2013-12-20 2015-06-25 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis and combinations thereof
WO2015105860A1 (en) * 2014-01-07 2015-07-16 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
US20150259292A1 (en) * 2011-03-08 2015-09-17 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
WO2016025816A1 (en) * 2014-08-15 2016-02-18 3-V Biosciences, Inc. Fatty acid synthase inhibitor for use in the treatment of drug resistant cancer
WO2016149271A1 (en) * 2015-03-19 2016-09-22 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
WO2007052843A1 (ja) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
DE602006011363D1 (de) 2005-12-01 2010-02-04 Hoffmann La Roche Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008059214A1 (en) 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
WO2008075077A1 (en) 2006-12-21 2008-06-26 Astrazeneca Ab Piperidine derivatives for the treatment of obesity
TW200833663A (en) 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
TW200831092A (en) 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
EP2485678A4 (en) 2009-10-07 2013-04-03 Univ Cornell Coferons and methods of making and using them
JP2013520502A (ja) * 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI522348B (zh) 2011-03-08 2016-02-21 3 V生物科技公司 脂質合成之雜環調節劑
KR102071095B1 (ko) 2012-07-03 2020-01-29 3-브이 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절인자
WO2014039769A1 (en) 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Imidazolin-5-one derivatives useful as fatty acid snthase (fasn) inhibitors for|the treatment of cancer
CA2932396C (en) * 2013-12-03 2022-03-29 Janssen Pharmaceutica Nv Benzamide derivative useful as fasn inhibitors for the treatment of cancer
CA2934257C (en) * 2013-12-17 2022-06-07 Janssen Pharmaceutica Nv Imidazolin-5-one derivative useful as fasn inhibitors for the treatment of cancer
CU24395B1 (es) * 2014-03-17 2019-04-04 Pfizer Inhibidores de diacilglicerol aciltransferasa 2

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122391A1 (en) * 2011-03-08 2012-09-13 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
US20150259292A1 (en) * 2011-03-08 2015-09-17 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
WO2015095767A1 (en) * 2013-12-20 2015-06-25 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis and combinations thereof
WO2015105860A1 (en) * 2014-01-07 2015-07-16 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
WO2016025816A1 (en) * 2014-08-15 2016-02-18 3-V Biosciences, Inc. Fatty acid synthase inhibitor for use in the treatment of drug resistant cancer
WO2016149271A1 (en) * 2015-03-19 2016-09-22 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis

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