JP7654557B2 - Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法 - Google Patents

Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法 Download PDF

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JP7654557B2
JP7654557B2 JP2021557613A JP2021557613A JP7654557B2 JP 7654557 B2 JP7654557 B2 JP 7654557B2 JP 2021557613 A JP2021557613 A JP 2021557613A JP 2021557613 A JP2021557613 A JP 2021557613A JP 7654557 B2 JP7654557 B2 JP 7654557B2
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エイヴリー ディー． ポージー
カール エイチ． ジューン
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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JP2021557613A 2019-03-27 2020-03-26 Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法 Active JP7654557B2 (ja)

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JP2024217382A JP2025038057A (ja) 2019-03-27 2024-12-12 Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法

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US201962824532P 2019-03-27 2019-03-27
US62/824,532 2019-03-27
US201962881269P 2019-07-31 2019-07-31
US62/881,269 2019-07-31
PCT/US2020/024825 WO2020198413A1 (en) 2019-03-27 2020-03-26 Tn-muc1 chimeric antigen receptor (car) t cell therapy

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JP7654557B2 true JP7654557B2 (ja) 2025-04-01

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JP2024217382A Pending JP2025038057A (ja) 2019-03-27 2024-12-12 Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法

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US (2) US11090336B2 (https=)
EP (1) EP3947471A4 (https=)
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CN (2) CN120944827A (https=)
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WO2020168122A1 (en) 2019-02-13 2020-08-20 Beam Therapeutics Inc. Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
JP7654557B2 (ja) * 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
GB202004371D0 (en) * 2020-03-26 2020-05-13 Glaxosmithkline Ip Dev Ltd CAR constructs
AU2021347359A1 (en) 2020-09-25 2023-05-18 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
WO2022087453A1 (en) * 2020-10-22 2022-04-28 Lyell Immunopharma, Inc. Chimeric activation receptors
CN114685684A (zh) * 2020-12-31 2022-07-01 博生吉医药科技(苏州)有限公司 MUC1-Tn嵌合抗原受体修饰的Vγ9Vδ2T细胞及其应用
CN112940137A (zh) * 2021-02-08 2021-06-11 广州安捷生物医学技术有限公司 一种pd-1基因敲除的靶向muc1的car-t细胞及其制备方法和应用
JP2024508894A (ja) * 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
KR20240007179A (ko) * 2021-04-30 2024-01-16 셀렉티스 에스.에이. 고형 종양 암 면역 요법을 위한 새로운 항-muc1 car 및 유전자 편집된 면역세포
US12576135B2 (en) * 2021-09-29 2026-03-17 Chimera Bioengineering, Inc. Compositions and methods for anti-TnMUC1 gold CAR t-cells
CN113943718B (zh) * 2021-10-11 2023-10-24 北京大学 一种糖基转移酶及其在Tn抗原的标记、成像和检测中的应用
EP4543467A2 (en) * 2022-06-24 2025-04-30 Orgenesis, Inc Chimeric antigen receptor with modified hinge and transmembrane domain and uses thereof
CN116284409A (zh) * 2022-07-08 2023-06-23 上海优替济生生物医药有限公司 Gpc3 car-t细胞及其在制备治疗癌症的药物中的用途
WO2024091848A2 (en) * 2022-10-25 2024-05-02 The Trustees Of The University Of Pennsylvania Anti-ceacam6 car-t cells for the treatment of ceacam6+ tumors
CN119978126A (zh) * 2023-11-10 2025-05-13 深圳市菲鹏生物治疗股份有限公司 抗muc16抗体、靶向muc16的嵌合抗原受体及其应用

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