JP7628320B2 - 変性hdlの定量方法、及びそれに用いる分析用試薬 - Google Patents

変性hdlの定量方法、及びそれに用いる分析用試薬 Download PDF

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JP7628320B2
JP7628320B2 JP2022512194A JP2022512194A JP7628320B2 JP 7628320 B2 JP7628320 B2 JP 7628320B2 JP 2022512194 A JP2022512194 A JP 2022512194A JP 2022512194 A JP2022512194 A JP 2022512194A JP 7628320 B2 JP7628320 B2 JP 7628320B2
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hdl
denatured
denatured hdl
binding protein
protein
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達也 沢村
明美 垣野
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • G01N2333/7456Factor V
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04Sandwich assay format
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders

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JP2022512194A 2020-03-30 2021-03-29 変性hdlの定量方法、及びそれに用いる分析用試薬 Active JP7628320B2 (ja)

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JP2020059965 2020-03-30
JP2020059965 2020-03-30
PCT/JP2021/013229 WO2021200797A1 (ja) 2020-03-30 2021-03-29 変性hdlの定量方法、及びそれに用いる分析用試薬

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006989A1 (fr) 2001-07-12 2003-01-23 Kyowa Medex Co., Ltd. Procede de quantification de lipoproteines denaturees, reactifs pour la quantification de lipoproteines denaturees, procede de detection de maladies du systeme circulatoire et reactifs pour la detection de maladies du systeme circulatoire
US20100055796A1 (en) 2007-04-11 2010-03-04 Markku Ahotupa Estimation and biological consequences of oxidative metabolism
JP4671823B2 (ja) 2004-09-27 2011-04-20 シスメックス株式会社 血液凝固因子の不活化方法及び血液凝固因子不活化試料
WO2015098901A1 (ja) 2013-12-27 2015-07-02 独立行政法人国立循環器病研究センター 抗血液凝固剤
WO2018079674A1 (ja) 2016-10-31 2018-05-03 国立大学法人大阪大学 脂質異常症治療が必要な被検者の選別方法及び選別用試薬
WO2019159934A1 (ja) 2018-02-14 2019-08-22 国立大学法人信州大学 融合タンパク質、及びそれを用いた高密度リポタンパク質の測定キット

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CA2200980C (en) 1994-11-30 2009-09-22 Tatsuya Sawamura Mammalian receptors for modified low-density lipoprotein
JP3436444B2 (ja) * 1995-07-21 2003-08-11 ヤマサ醤油株式会社 酸化hdlの測定法及びキット
ATE512982T1 (de) * 2001-08-17 2011-07-15 Exothera L L C Verfahren und zusammensetzung zum gezielten einbringen in exosome
JP2003279571A (ja) * 2002-03-20 2003-10-02 Kyowa Hakko Kogyo Co Ltd 炎症性疾患検出方法、検出薬、およびその予防治療薬探索方法
JP5706669B2 (ja) 2010-11-10 2015-04-22 独立行政法人国立循環器病研究センター 融合タンパク質、核酸、ベクター、細胞、labの測定方法、並びに、lab測定用キット
JP6231307B2 (ja) 2013-06-27 2017-11-15 中野 恵正 機能不全hdlの測定方法、機能不全hdl測定用キット、並びに、生活習慣病マーカーの測定方法
JP6096360B1 (ja) 2016-08-12 2017-03-15 旭サナック株式会社 ワーク姿勢変更装置および多工程圧造機
CN109580960A (zh) * 2019-01-14 2019-04-05 周明 细胞外囊泡的分离方法、以及检测细胞外囊泡表面标志物的方法和试剂盒

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006989A1 (fr) 2001-07-12 2003-01-23 Kyowa Medex Co., Ltd. Procede de quantification de lipoproteines denaturees, reactifs pour la quantification de lipoproteines denaturees, procede de detection de maladies du systeme circulatoire et reactifs pour la detection de maladies du systeme circulatoire
JP4671823B2 (ja) 2004-09-27 2011-04-20 シスメックス株式会社 血液凝固因子の不活化方法及び血液凝固因子不活化試料
US20100055796A1 (en) 2007-04-11 2010-03-04 Markku Ahotupa Estimation and biological consequences of oxidative metabolism
WO2015098901A1 (ja) 2013-12-27 2015-07-02 独立行政法人国立循環器病研究センター 抗血液凝固剤
WO2018079674A1 (ja) 2016-10-31 2018-05-03 国立大学法人大阪大学 脂質異常症治療が必要な被検者の選別方法及び選別用試薬
WO2019159934A1 (ja) 2018-02-14 2019-08-22 国立大学法人信州大学 融合タンパク質、及びそれを用いた高密度リポタンパク質の測定キット

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAKINO, A. et al.,A Novel Cell-free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL,Journal of Atherosclerosis and Thrombosis,2019年,Vol.26, No.11,pp.947-958
KAKINO, A. et al.,A NOVEL METHOD TO QUANTIFY THE BIOLOGICAL ACTIVITY OF MODIFIED HDL,International Symposium on Atherosclerosis (ISA) 2018 Abstract Book,2018年06月05日,Vol.32, P1.008,p.35
垣野明美 ほか,変性HDL活性測定系の樹立とリスク評価への有用性の検討,日本生化学会大会プログラム・講演予稿集,2019年,第92回, 2P-386,pp.706-707

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EP4130030A4 (en) 2024-03-27
EP4130030A1 (en) 2023-02-08
CN115698713A (zh) 2023-02-03
WO2021200797A1 (ja) 2021-10-07
US20230288437A1 (en) 2023-09-14
JPWO2021200797A1 (https=) 2021-10-07

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